Okadaic acid influences xenobiotic metabolism in HepaRG cells [PDF]
EXCLI Journal : Experimental and Clinical Sciences, 2022 Okadaic acid (OA) is an algae-produced lipophilic marine biotoxin that accumulates in the fatty tissue of filter-feeding shellfish. Ingestion of contaminated shellfish leads to the diarrheic shellfish poisoning syndrome.
Leonie T. D. Wuerger +5 more
doaj +4 more sources
Okadaic Acid Depuration from the Cockle Cerastoderma edule [PDF]
Toxins, 2022 The cockle Cerastoderma edule is a commercially important species in many European Countries. It can accumulate okadaic acid (OA) and other toxins in its group, which makes it unsuitable for human consumption, producing harvesting bans to avoid ...
Juan Blanco +3 more
doaj +4 more sources
Proteomic analysis of hepatic effects of okadaic acid in HepaRG human liver cells [PDF]
EXCLI Journal : Experimental and Clinical Sciences, 2023 The marine biotoxin okadaic acid (OA) is produced by dinoflagellates and enters the human food chain by accumulating in the fatty tissue of filter-feeding shellfish.
Leonie T. D. Wuerger +4 more
doaj +2 more sources
Expression Analyses of Genes Related to Multixenobiotic Resistance in Mytilus galloprovincialis after Exposure to Okadaic Acid-Producing Dinophysis acuminata [PDF]
Toxins, 2021 The mussel Mytilus galloprovincialis is one of the most important aquaculture species in Europe. Its main production problem is the accumulation of toxins during coastal blooms, which prevents mussel commercialization. P-glycoprotein (ABCB1/MDR1/P-gp) is
Roi Martínez-Escauriaza +5 more
doaj +2 more sources
In Vitro Interactions between Okadaic Acid and Rat Gut Microbiome [PDF]
Marine Drugs, 2022 Okadaic acid (OA) is a marine biotoxin associated with diarrhetic shellfish poisoning (DSP), posing some threat to human beings. The oral toxicity of OA is complex, and the mechanism of toxicity is not clear. The interaction between OA and gut microbiota
Yang Liu +5 more
doaj +2 more sources
Simple Diffusion as the Mechanism of Okadaic Acid Uptake by the Mussel Digestive Gland [PDF]
Toxins, 2019 Okadaic acid (OA) and other toxins of the diarrheic shellfish poisoning (DSP) group are accumulated and transformed mainly in many bivalves, inside the digestive gland cells.
Juan Blanco +3 more
doaj +2 more sources
Combined Cytotoxicity of the Phycotoxin Okadaic Acid and Mycotoxins on Intestinal and Neuroblastoma Human Cell Models [PDF]
Toxins, 2018 Mycotoxins are emerging toxins in the marine environment, which can co-occur with algal toxins to exert synergistic or antagonistic effects for human seafood consumption.
Aiko Hayashi +3 more
doaj +2 more sources
Kolaviron neuroprotective effect against okadaic acid-provoked cognitive impairment [PDF]
HeliyonAlzheimer's disease (AD) is acknowledged as the main causative factor of dementia that affects millions of people around the world and is increasing at increasing pace.
Morteza Nazari-Serenjeh +9 more
doaj +2 more sources
Utilizing zebrafish and okadaic acid to study Alzheimer’s disease
Neural Regeneration Research, 2018 Despite the many years of extensive research using rodent models to study Alzheimer’s disease (AD), no cure or disease halting drug exists. An increasing number of people are suffering from the disease and a therapeutic intervention is needed. Therefore,
Daniel Koehler, Frederick E Williams
doaj +2 more sources
Enhanced insulin sensitivity associated with provision of mono and polyunsaturated fatty acids in skeletal muscle cells involves counter modulation of PP2A [PDF]
, 2014 International audienceAims/Hypothesis: Reduced skeletal muscle insulin sensitivity is a feature associated with sustained exposure to excess saturated fatty acids (SFA), whereas mono and polyunsaturated fatty acids (MUFA and PUFA) not only improve ...
A El-Yassimi +52 more
core +16 more sources