Results 101 to 110 of about 22,727 (219)

Is Protein Phosphatase Inhibition Responsible for the Toxic Effects of Okadaic Acid in Animals?

Toxins, 2013
Okadaic acid (OA) and its derivatives, which are produced by dinoflagellates of the genera Prorocentrum and Dinophysis, are responsible for diarrhetic shellfish poisoning in humans.
Rex Munday
doaj   +1 more source

Expression of Smooth Muscle Myosin Heavy Chains and Unloaded Shortening in Single Smooth Muscle Cells [PDF]

, 1997
The functional significance of the variable expression of the smooth muscle myosin heavy chain (SM-MHC) tail isoforms, SM1 and SM2, was examined at the mRNA level (which correlates with the protein level) in individual permeabilized rabbit arterial ...
Eddinger, Thomas, Meer, Daniel P.
core   +1 more source

Ebola virus VP35 induces high-level production of recombinant TPL-2–ABIN-2–NF-κB1 p105 complex in co-transfected HEK-293 cells [PDF]

, 2013
Activation of PKR (double-stranded-RNA-dependent protein kinase) by DNA plasmids decreases translation, and limits the amount of recombinant protein produced by transiently transfected HEK (human embryonic kidney)-293 cells.
Apostolaki, Baldi, Beinke, Beinke, Beinke, Beinke, Beinke, Belich, Bouwmeester, Ciechanover, Cohen, Coope, Costa, Dauber, Dumitru, Durocher, Elke MÜHLBERGER, Feng, Gantke, Geisse, George, Gray, Jia, Jia, Julia Janzen, Kabouridis, Kaufman, Lang, Liu, Nicholas A. Morrice, Papoutsopoulou, Pomerantz, Robinson, Roget, Sabrina Boussouf, Salmeron, Salmeron, Savinova, Schlaeger, Schumann, Steven Howell, Steven C. Ley, Thorsten Gantke, Waterfield, Waterfield, Wu, Yang, Zhao   +47 more
core   +1 more source

Phosphorylation of Spinophilin Modulates Its Interaction with Actin Filaments [PDF]

, 2003
Spinophilin is a protein phosphatase 1 (PP1)- and actin-binding protein that modulates excitatory synaptic transmission and dendritic spine morphology. We report that spinophilin is phosphorylated in vitro by protein kinase A (PKA).
Allen, Patrick B., Benfenati, Fabio, Greengard, Paul, Hsieh-Wilson, Linda C., Nairn, Angus C., Snyder, Gretchen L.   +5 more
core  

Activation of AtMPK9 through autophosphorylation that makes it independent of the canonical MAPK cascades. [PDF]

, 2015
Mitogen activated protein kinases (MAPKs) are part of conserved signal transduction modules in eukaryotes that are typically organised into three-tiered kinase cascades.
Bogre L, Bánhegyi, Gábor, Darula, Zsuzsanna, Horváth V., Gábor, Kállai, Brigitta Margit, Medzihradszky F., Katalin, Mészáros, Tamás, Nagy, Szilvia Krisztina   +7 more
core   +1 more source

Unfair competition governs the interaction of pCPI-17 with myosin phosphatase (PP1-MYPT1). [PDF]

, 2017
The small phosphoprotein pCPI-17 inhibits myosin light-chain phosphatase (MLCP). Current models postulate that during muscle relaxation, phosphatases other than MLCP dephosphorylate and inactivate pCPI-17 to restore MLCP activity.
Eto, Masumi, Filter, Joshua J., Goldberg, Michael L., Shalloway, David, Williams, Byron C.   +4 more
core   +2 more sources

A new pathway for neuroprotection against tau hyperphosphorylation via δ-opioid receptor initiated inhibition of CDK5 and AMPK signaling

Frontiers in Aging Neuroscience
IntroductionAlzheimer’s disease (AD) is a progressive neurodegenerative disease characterized by decreased memory and cognitive impairment. Abnormal tau hyperphosphorylation ultimately forms neurofibrillary tangles, which is one of the most important ...
Jiahui Li, Jiahui Li, Yuan Xu, Yuan Xu, Gianfranco Balboni, Ying Xia, Ying Xia   +6 more
doaj   +1 more source

Current situation on analysis of marine toxins

Reviews in Analytical Chemistry, 2013
Marine toxins are a food safety concern worldwide. This review discusses current analytical methods for those toxins that are legally regulated in Europe, namely domoic acid, saxitoxin, okadaic acid, yessotoxin, pectenotoxin and azaspiracids, and all ...
Botana Ana M., Otero Paz, Rodríguez Paula, Alfonso Amparo, Botana Luis M.   +4 more
doaj   +1 more source

Generation of Internal-Image Functional Aptamers of Okadaic Acid via Magnetic-Bead SELEX

Marine Drugs, 2015
Okadaic acid (OA) is produced by Dinophysis and Prorocentrum dinoflagellates and primarily accumulates in bivalves, and this toxin has harmful effects on consumers and operators. In this work, we first report the use of aptamers as novel non-toxic probes
Chao Lin, Zeng-Shan Liu, Dong-Xu Wang, Lin Li, Pan Hu, Sheng Gong, Yan-Song Li, Cheng Cui, Zong-Cheng Wu, Yang Gao, Yu Zhou, Hong-Lin Ren, Shi-Ying Lu   +12 more
doaj   +1 more source

Evaluación del modo de acción de toxinas de dinoflagelados y cianobacterias en células hepáticas [PDF]

, 2013
El mar es fuente de buena parte de los alimentos que consume el ser humano. Además del agua marina, el hombre también se beneficia, de diversas maneras, de los recursos de agua dulce.
López Alonso, Henar
core   +1 more source