Results 51 to 60 of about 22,727 (219)
The Journal of Physiology, EarlyView.Abstract figure legend Catecholaminergic polymorphic ventricular tachycardia (CPVT) variants in N terminal (NTD) and central domain (CD) but not pore domain induce a pathological RyR2 conformational shift upon protein kinase A (PKA) phosphorylation, similar to that seen in heart failure (HF), calcium/calmodulin‐dependent protein kinase II (CaMKII ...
Hitoshi Uchinoumi +11 more
wiley +1 more source
Self-Association of Okadaic Acid: Structural and Pharmacological Significance
Marine Drugs, 2013 Okadaic acid (OA) has been an invaluable pharmacological tool in the study of cellular signaling. The great affinity of this polyether for its targets together with its high specificity to inhibit certain protein phosphatases enables the differential ...
José J. Fernández +4 more
doaj +1 more source
Structure determination of new algal toxins using NMR methods [PDF]
, 2006 Shellfish are considered a delicacy by many consumers. In NZ, as in many overseas countries, there is a now thriv¬ing shellfish industry servicing both domestic and inter-national markets. Periodically shellfish accumulate harm¬ful levels of a variety of
Miles, Christopher O. +1 more
core
Advanced Science, Volume 13, Issue 6, 30 January 2026.Prenatal dexamethasone exposure (PDE) persistently upregulates hepatic CYP3A1/CYP2B1 in offspring via glucocorticoid receptor (GR) activation. In vivo and in vitro studies show GR promotes P300/CBP binding to the constitutive androstane receptor (CAR) promoter, sustaining histone acetylation (H3K9/K27ac) and enhancing CYP expression. The GR–CAR pathway
Xiaoxiang Sun +9 more
wiley +1 more source
A rapid competitive ELISA assay of Okadaic acid level based on epoxy-functionalized magnetic beads
Food and Agricultural Immunology, 2019 Using newly designed epoxy group activated carbon shell magnetic beads as a goat against mouse antibody (G-Mab) carrier, a competitive immunoassay was conducted on the surface of G-Mab-coated magnetic beads (G-Mab-MBs).
Linjiang Pang +8 more
doaj +1 more source
Cancer Medicine, Volume 15, Issue 1, January 2026.ABSTRACT Background Bladder cancer remains a significant challenge in oncology owing to its high recurrence rates and limited treatment options, particularly in cases of resistance to standard therapies. Aims Our study aimed to pinpoint a lactylation‐associated gene signature capable of predicting prognosis and providing important theoretical support ...
Jingsong Wang +8 more
wiley +1 more source
Identification of a Phosphorylation Site for Calcium/Calmodulindependent Protein Kinase II in the NR2B Subunit of the N-Methyl-D-aspartate Receptor [PDF]
, 1996 The N-methyl-D-aspartate (NMDA) subtype of excitatory glutamate receptors plays critical roles in embryonic and adult synaptic plasticity in the central nervous system.
Alan J. Rosenstein +51 more
core +1 more source
Exploring Autophagy Inducing Molecules: Targeting Diverse Pathways in Alzheimer's Disease Management
Medicinal Research Reviews, Volume 46, Issue 1, Page 272-298, January 2026.ABSTRACT Neurodegenerative disorders, including Alzheimer's disease (AD), impose a significant burden on society due to their progressive nature and the associated healthcare costs. Autophagy, a vital cellular degradation process, has emerged as a promising therapeutic target in these disorders.
Baljinder Singh +4 more
wiley +1 more source
Minisatellite Instability Induced by Okadaic Acid.
THE JOURNAL OF THE STOMATOLOGICAL SOCIETY,JAPAN, 1997 Okadaic acid (OA) is an inhibitor of serine/threonine protein phosphatase (PP) and a tumor promoter in mouse skin carcinogenesis. According to Carcinogenesis Division, National Cancer Center Research Institute, OA induces various genetic alterations, such as loss of exogenous genes, sister chromatid exchanges and diphtheria toxin resistant mutants ...
openaire +3 more sources
Plant Direct, Volume 10, Issue 1, January 2026.ABSTRACT Despite being one of the few bona fide plant tyrosine phosphatases, the Arabidopsis thaliana Rhizobiales‐like phosphatase 2 (RLPH2) has no known substrates. Utilizing phospho‐proteomics, we identified the activation loop phospho‐tyrosine of several A. thaliana D‐group mitogen‐activated protein kinases (MPKs) as potential RLPH2 substrates.
Anne‐Marie Labandera +8 more
wiley +1 more source