Results 71 to 80 of about 22,727 (219)

NETosis‐Like Response Triggered by Extracellular Vesicle (EV)‐Delivered Viral Nucleic Acid, a Novel Cellular Immune Mechanism in Crustacean

Journal of Extracellular Vesicles, Volume 14, Issue 12, December 2025.
ABSTRACT As a novel identified manner of cell death, NETosis is widely regarded as an effective approach to resist pathogen infection but mainly focused on vertebrates with systematic cell typing. Besides, the role of extracellular vesicles (EVs), which are essential tools for intercellular information exchange, in regulating NETosis during pathogen ...
Hang Hu, Chunyi Zhong, Xinshan Zhao, Cheng Yi, Yi Gong   +4 more
wiley   +1 more source

Experimental Basis for the High Oral Toxicity of Dinophysistoxin 1: A Comparative Study of DSP

Toxins, 2014
Okadaic acid (OA) and its analogues, dinophysistoxin 1 (DTX1) and dinophysistoxin 2 (DTX2), are lipophilic and heat-stable marine toxins produced by dinoflagellates, which can accumulate in filter-feeding bivalves.
Diego A. Fernández, M. Carmen Louzao, María Fraga, Natalia Vilariño, Mercedes R. Vieytes, Luis M. Botana   +5 more
doaj   +1 more source

Grazer‐induced bioluminescence and toxicity in marine dinoflagellates

Limnology and Oceanography, Volume 70, Issue 12, Page 3769-3783, December 2025.
Abstract Marine copepods are the most abundant multicellular zooplankton in the global oceans. They imprint their surrounding waters with a unique bouquet of chemical compounds, including polar lipids such as copepodamides. Prey organisms can detect copepodamides and respond by inducing defensive traits including bioluminescence, toxin production ...
Paula Gonzalo‐Valmala, Milad Pourdanandeh, Sandra Lage, Erik Selander   +3 more
wiley   +1 more source

Ring Finger Protein 1, a Novel Ubiquitin E3 Ligase Targeting Cancerous Inhibitor of Protein Phosphatase 2A to Suppress Smoking‐Induced Lung Tumorigenesis

MedComm, Volume 6, Issue 12, December 2025.
Schematic illustration of the roles of CIP2A and RING1 in lung tumorigenesis Accumulation of DNMT1 due to NNK exposure leads to a reduction in RING1 mRNA levels. Decreased RING1 results in an accumulation of CIP2A protein levels and upregulated CIP2A suppresses PP2A activity, consequently increasing the stability of c‐MYC.
In‐ho Jeong, Jae Kwang Yun, Jun‐O. Jin, Geun Dong Lee, Peter Chang‐Whan Lee   +4 more
wiley   +1 more source

Activation of the Tumor Suppressor PP2A Emerges as a Potential Therapeutic Strategy for Treating Prostate Cancer

Marine Drugs, 2015
Protein phosphatase 2A (PP2A) is a tumor suppressor complex that has recently been reported as a novel and highly relevant molecular target in prostate cancer (PCa). However, its potential therapeutic value remains to be fully clarified.
Ion Cristóbal, Paula González-Alonso, Lina Daoud, Esther Solano, Blanca Torrejón, Rebeca Manso, Juan Madoz-Gúrpide, Federico Rojo, Jesús García-Foncillas   +8 more
doaj   +1 more source

GABA(A) receptor phospho-dependent modulation is regulated by phospholipase C-related inactive protein type 1, a novel protein phosphatase 1 anchoring protein [PDF]

, 2004
GABA(A) receptors are critical in controlling neuronal activity. Here, we examined the role for phospholipase C-related inactive protein type 1 (PRIP-1), which binds and inactivates protein phosphatase 1alpha (PP1alpha) in facilitating GABA(A) receptor ...
Akaike, N, Ha, SH, Hirata, M, Jang, IS, Jovanovic, JN, Kanematsu, T, Kittler, JT, Moss, SJ, Nakayama, KI, Ryu, SH, Terunuma, M   +10 more
core  

Inhibitory effect of polyunsaturated fatty acids on apoptosis induced by etoposide, okadaic acid and AraC in Neuro2a cells [PDF]

, 2007
Neuronal apoptosis is involved in neurodegenerative diseases such as Alzheimer's disease and Parkinson.s disease. An efficient means of preventing it remains to be found. Some n-3 polyunsaturated fatty acids (PUFAs) such as docosahexaenoic acid (DHA, 22 :
Matsui, Hideki, Tada, Mikiro, Takahata, Kyoya, Tomizawa, Kazuhito, Wu, Yumei   +4 more
core   +1 more source

Okadaic acid–induced apoptosis in malignant glioma cells [PDF]

Neurosurgical Focus, 2003
Object Okadaic acid (OA), a potent protein phosphatase inhibitor, has been known to induce apoptosis in a variety of cell types. The authors attempted to characterize further this model by identifying proteins involved in this form of programmed cell death.
Bimal G, Rami, Lawrence S, Chin, Barbara E, Lazio, Satyendra K, Singh   +3 more
openaire   +2 more sources

Exploiting PP2A dependent and independent effects of forskolin for therapeutic targeting of KMT2A (MLL)‐rearranged acute leukaemia

British Journal of Pharmacology, Volume 182, Issue 24, Page 6043-6062, December 2025.
Background and Purpose Activation of Protein Phosphatase 2A (PP2A), via genetic and pharmacologic modulation of SET, has recently being identified as a promising strategy to therapeutically target acute myeloid leukaemia (AML) carrying KMT2A (MLL) chromosomal translocations (KMT2A‐r AML).
Yoana Arroyo‐Berdugo, Antonella Di Mambro, Volker Behrends, Michelle A. Sahai, Luca Cozzuto, Immacolata Zollo, Julia Ponomarenko, Owen Williams, John Gribben, Yolanda Calle, Bela Patel, Maria Teresa Esposito   +11 more
wiley   +1 more source

Identification of 19-epi-okadaic Acid, a New Diarrhetic Shellfish Poisoning Toxin, by Liquid Chromatography with Mass Spectrometry Detection

Marine Drugs, 2008
Okadaic acid (1) (OA) and its congeners are mainly responsible for diarrhetic shellfish poisoning (DSP) syndrome. The presence of several OA derivatives have already been confirmed in Prorocentrum and Dinophysis spp.
José J. Fernández, Manuel Norte, José M. Franco, Patricia G. Cruz, Antonio H. Daranas, Beatriz Paz   +5 more
doaj