Results 81 to 90 of about 22,727 (219)

Microcystins Alter Chemotactic Behavior in Caenorhabditis elegans by Selectively Targeting the AWA Sensory Neuron

Toxins, 2014
Harmful algal blooms expose humans and animals to microcystins (MCs) through contaminated drinking water. While hepatotoxicity following acute exposure to MCs is well documented, neurotoxicity after sub-lethal exposure is poorly understood. We developed
Caroline E. Moore, Pamela J. Lein, Birgit Puschner   +2 more
doaj   +1 more source

The Concise Guide to PHARMACOLOGY 2025/26: Ion channels

British Journal of Pharmacology, Volume 182, Issue S1, Page S152-S241, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Jörg Striessnig, Alasdair J. Gibb, Alistair A. Mathie, Emma L. Veale, Eamonn Kelly, Chloe J. Peach, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Richard W. Aldrich, Bernard Attali, Austin M. Baggetta, Elvir Becirovic, David J. Beech, Martin Biel, Roslyn M. Bill, Ana I. Caceres, William A. Catterall, Han Chow Chua, Alex C. Conner, Henry Danahay, Paul Davies, Katrien De Clerq, Markus Delling, Francesco Di Virgilio, Simonetta Falzoni, Wei Fang, Stefanie Fenske, Anna Fortuny‐Gomez, Samuel Fountain, George K. Chandy, Mohammad‐Reza Ghovanloo, Steve A. N. Goldstein, Martin Gosling, Christian Grimm, Stephan Grissmer, Kotdaji Ha, Tim G. Hales, Verena Hammelmann, Israel Hanukoglu, Meiqin Hu, Ad P. Ijzerman, Sairam V. Jabba, Mike Jarvis, Anders A. Jensen, Sven E. Jordt, Leonard K. Kaczmarek, Stephan Kellenberger, Charles Kennedy, Brian King, Philip Kitchen, Qiang Liu, Joseph W. Lynch, Rian W. Manville, Jessica Meades, Verena Mehlfeld, Annette Nicke, Stefan Offermanns, Edward Pérez‐Reyes, Leigh D. Plant, Stephan A. Pless, Lachlan D. Rash, Dejian Ren, Hussein N. Rubaiy, Mootaz M. Salman, Werner Sieghart, Lucia G. Sivilotti, Trevor G. Smart, Terrance P. Snutch, Paolo Tammaro, Jinbin Tian, James S. Trimmer, Charlotte Van den Eynde, Paola Vergani, Joris Vriens, Stephen G. Waxman, Aguan D. Wei, Brenda T. Winn, Heike Wulff, Haoxing Xu, Fan Yang, Lixia Yue, Xiaoli Zhang, Michael Zhu   +86 more
wiley   +1 more source

Quantitative Nuclear Magnetic Resonance Spectroscopy Based on PULCON Methodology: Application to Quantification of Invaluable Marine Toxin, Okadaic Acid

Toxins, 2016
ERETIC2 (Electronic Reference To access In vivo Concentrations 2) based on PULCON (Pulse Length–based Concentration determination) methodology is a quantitative NMR (qNMR) using an external standard.
Ryuichi Watanabe, Chika Sugai, Taichi Yamazaki, Ryoji Matsushima, Hajime Uchida, Masahiro Matsumiya, Akiko Takatsu, Toshiyuki Suzuki   +7 more
doaj   +1 more source

Influence of epigallocatechin-3-gallate on okadaic acid-induced cell death [PDF]

, 2015
Okadaična kiselina je selektivni inhibitor serin/treonin fosfataza (PP1 i PP2A) koje kataliziraju defosforilaciju tau proteina i pojačava ekspresiju gena cdk5 i p25. Cdk5 inhibira fosfataze i time inducira hiperfosforilaciju tau proteina.
Kopčok, Vedrana
core  

Phosphorylation of BK channels modulates the sensitivity to hydrogen sulfide (H2S) [PDF]

, 2014
Introduction: Gases, such as nitric oxide (NO), carbon monoxide (CO) or hydrogen sulfide (H2S), termed gasotransmitters, play an increasingly important role in understanding of how electrical signaling of cells is modulated.
Anton eHermann, Guzel F. Sitdikova, Roman eFuchs, Roman eFuchs, Thomas M. Weiger, Verena eKainz   +5 more
core   +2 more sources

Foodborne Hazards and Novel Technologies in Ready‐to‐Eat Crustaceans

Food Frontiers, Volume 6, Issue 6, Page 2647-2672, November 2025.
Biological hazards, including Listeria monocytogenes, norovirus, Salmonella, and Vibrio spp., and chemical hazards, including heavy metals, biotoxins, pesticides, pharmaceuticals, and personal care products, are of great concern regarding crustaceans and their consumption.
Dongli Dong, Selene Pedrós‐Garrido, Daniel Hurley, James Lyng   +3 more
wiley   +1 more source

Diverse Bacterial PKS Sequences Derived From Okadaic Acid-Producing Dinoflagellates

Marine Drugs, 2008
Okadaic acid (OA) and the related dinophysistoxins are isolated from dinoflagellates of the genus Prorocentrum and Dinophysis. Bacteria of the Roseobacter group have been associated with okadaic acid producing dinoflagellates and have been previously ...
Kathleen S. Rein, Tianying An, Jose Lopez, Li Liu, Roberto Perez   +4 more
doaj  

Protein kinase C modulates the activity of a cloned gamma-aminobutyric acid transporter expressed in Xenopus oocytes via regulated subcellular redistribution of the transporter [PDF]

, 1994
We report that activators and inhibitors of protein kinase C (PKC) and protein phosphatases regulate the activity of a cloned rat brain gamma- aminobutyric acid (GABA) transporter (GAT1) expressed in Xenopus oocytes.
Brecha, Nicholas, Corey, Janis L., Davidson, Norman, Lester, Henry A., Quick, Michael W.   +4 more
core  

Protein phosphatase beta, a putative type-2A protein phosphatase from the human malaria parasite Plasmodium falciparum. [PDF]

, 1997
Protein phosphatases play a critical role in the regulation of the eukaryotic cell cycle and signal transduction. A putative protein serine/threonine phosphatase gene has been isolated from the human malaria parasite Plasmodium falciparum.
Arndt K. T., Barton G. J., Bruce M. C., Chen J., Chen J., Day K. P., Favre B., Kamibayashi C., Kennelly P. I., Lee J., Li I. L., Lin F. C., Lorca T., Nussenzweig R. S., Pallas D. C., Posas F., Rangachari K., Read L. K., Ronne H., Ross-MacDonald P. B., Shima H., Snaith H. A., Sneddon A. A., Stone S. R., Sutton A., Wera S., Xie H., Zhang Z., Zhang Z., Zhao Y., Zhao Y., Zhuo S., Zolnierowicz S.   +32 more
core   +1 more source

Effect of okadaic acid on human basophil secretion

Biochemical Pharmacology, 1993
We examined the effects of a phosphatase inhibitor, okadaic acid, on mediator secretion from human basophils. These cells are known to respond to a number of stimuli that appear to utilize distinct biochemical pathways converging on mediator release.
L M, Botana, D W, MacGlashan
openaire   +2 more sources