Results 31 to 40 of about 2,813,688 (177)
Use of Okadaic Acid to Identify Relevant Phosphoepitopes in Pathology: A Focus on Neurodegeneration
Marine Drugs, 2013 Protein phosphorylation is involved in the regulation of a wide variety of physiological processes and is the result of a balance between protein kinase and phosphatase activities. Biologically active marine derived compounds have been shown to represent
Jesús Avila +2 more
doaj +1 more source
Marine Drugs, 2023 Marine toxins (MTs) are a group of structurally complex natural products with unique toxicological and pharmacological activities. In the present study, two common shellfish toxins, okadaic acid (OA) (1) and OA methyl ester (2), were isolated from the ...
Dong Huang +9 more
doaj +1 more source
Journal of Environmental Chemistry, 2010 The preparation of the reference material (RM) for mouse bioassay (MBA) of diarrheic shellfish poisoning (DSP) toxin was attempted. To obtain basic data on the RM, the stability of okadaic acid (OA), which causes DSP, and the method of spiking scallop tissue with OA were examined.
KAWASAKI, Masaru +3 more
openaire +2 more sources
Exposure to okadaic acid could disrupt the colonic microenvironment in rats
Ecotoxicology and Environmental Safety, 2023 Okadaic acid (OA) is one of the most prevalent marine phycotoxin with complex toxicity, which can lead to toxic symptoms such as diarrhea, vomiting, nausea, abdominal pain, and gastrointestinal discomfort. Studies have shown that the main affected tissue
Yang Liu +7 more
doaj +1 more source
Cell Death Inducing Microbial Protein Phosphatase Inhibitors—Mechanisms of Action
Marine Drugs, 2015 Okadaic acid (OA) and microcystin (MC) as well as several other microbial toxins like nodularin and calyculinA are known as tumor promoters as well as inducers of apoptotic cell death.
Rune Kleppe +2 more
doaj +1 more source
Zhongguo shipin weisheng zazhi, 2022 ObjectiveTo prepare the standard sample for quantitative analysis of okadaic acid （OA） and dinophysistoxins-1 （DTX1） based on the mixed matrix of Pectinidae and Prorocentrum lima.MethodsPectinidae tissue and algae mud of Prorocentrum lima containing OA ...
WANG Wei +5 more
doaj +1 more source
Okadaic acid induces damage of human neuroblastoma cell line SH-SY5Y [PDF]
Jichu yixue yu linchuang, 2022 Objective To investigate the effect of okadaic acid (OA)-induced phosphorylation of neuron micro-tubule associated protein tau (Tau) on the damage of human neuroblastoma SH-SY5Y cells.
LU Ya-lan, ZHOU Li, HAN Yun-lin, WANG Ke-wei, QIN Chuan
doaj +1 more source
Toxins, 2023 Okadaic acid (OA), a marine biotoxin produced by microalgae, poses a significant threat to mariculture, seafood safety, and human health. The establishment of a novel, highly sensitive detection method for OA would have significant practical and ...
Yuan Qin +7 more
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Micromachines, 2022 In this investigation, a double immunochromatographic analysis (ICA) of two relevant phycotoxins, domoic acid (DA) and okadaic acid (OA), was developed for the first time.
Olga D. Hendrickson +6 more
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Boletín de la Sociedad Argentina de BotánicaIn January 2010, the toxin-producing dinoflagellates Dinophysis acuminata and D. caudata (103 cells·l-1) were detected in Mar Azul during routine plankton monitoring in Buenos Aires Province coastal waters, Argentina.
Eugenia A. Sar +6 more
doaj +1 more source