Results 71 to 80 of about 84,234 (301)

Pharmacogenomics of Major Depressive Disorder in Indigenous Amazonian Populations

Clinical Pharmacology &Therapeutics, EarlyView.
Major depressive disorder is a highly prevalent psychological disorder worldwide and its main treatment is the use of Selective Serotonin Reuptake Inhibitors. However, few studies have demonstrated the relationship between the presence of genetic variants in pharmacogenes and the efficacy of these drugs, especially in populations with a unique genetic ...
Kaio Evandro Cardoso Aguiar, Natasha Monte da Silva, Juliana Carla Gomes Rodrigues, André Maurício Ribeiro‐dos‐Santos, Sandro José de Souza, Ândrea Ribeiro‐dos‐Santos, João Farias Guerreiro, Sidney Emanuel Batista dos Santos, Marianne Rodrigues Fernandes, Ney Pereira Carneiro dos Santos   +9 more
wiley   +1 more source

Genetic Association of Olanzapine Treatment Response in Han Chinese Schizophrenia Patients

Frontiers in Pharmacology, 2019
Olanzapine, a second-generation antipsychotic medication, plays a critical role in current treatment of schizophrenia (SCZ). It has been observed that the olanzapine responses in schizophrenia treatment are different across individuals.
Wei Zhou, Yong Xu, Qinyu Lv, Yong-hui Sheng, Luan Chen, Mo Li, Lu Shen, Cong Huai, Zhenghui Yi, Donghong Cui, Donghong Cui, Shengying Qin, Shengying Qin   +12 more
doaj   +1 more source

Acute olanzapine toxicity in a toddler

Open Journal of Psychiatry and Allied Sciences, 2020
Olanzapine is an antipsychotic medication, which is approved for treatment of psychiatric illnesses among various age groups of psychiatric patients. Accidental consumption of olanzapine is uncommon among the paediatric age group.
Hemendra Singh, Sahana Amarnath Boggaram, Mamatha Krishna Murthy, ATK Rau   +3 more
doaj   +1 more source

Attenuation of Olanzapine-Induced Endoplasmic Reticulum Stress Improves Insulin Secretion in Pancreatic Beta Cells

Metabolites, 2022
Second-generation antipsychotics (SGAs), in particular, olanzapine and clozapine, have been associated with the development of type 2 diabetes mellitus (T2D) and metabolic syndrome in individuals with schizophrenia. In this context, beta cell dysfunction
Diana Grajales, Patricia Vázquez, Rosa Alén, Ana B. Hitos, Ángela M. Valverde   +4 more
doaj   +1 more source

The longitudinal interplay between negative and positive symptom trajectories in patients under antipsychotic treatment: a post hoc analysis of data from a randomized, 1-year pragmatic trial [PDF]

, 2013
BACKGROUND: Schizophrenia is a highly heterogeneous disorder with positive and negative symptoms being characteristic manifestations of the disease. While these two symptom domains are usually construed as distinct and orthogonal, little is known about ...
Ascher-Svanum, H, Chen, L, Johnston, JA, Kinon, BJ, Marques, TR, Stauffer, V, Succop, P   +6 more
core   +2 more sources

Olanzapine Form IV: Discovery of a New Polymorphic Form Enabled by Computed Crystal Energy Landscapes

Crystal Growth & Design, 2019
Olanzapine is a polymorphic drug molecule that has been extensively studied, with over 60 structures reported in the Cambridge Structural Database. All anhydrous and solvated forms of olanzapine known to date contain the SC0 dimer packing motif.
Sean Askin, J. Cockcroft, L. Price, A. Goncalves, Min Zhao, D. Tocher, Gareth R. Williams, S. Gaisford, D. Craig   +8 more
semanticscholar   +1 more source

Advancing Maternal Health with Long‐Acting Therapeutics: Priorities, Efficacy and Safety Considerations, and Emerging Technologies

Clinical Pharmacology &Therapeutics, EarlyView.
Maternal health remains a critical global concern, particularly in underserved populations and in low‐ and middle‐income countries where access to safe and effective therapeutics is limited. Despite the use of medications by most women during pregnancy, the exclusion of pregnant and lactating women from clinical trials has resulted in significant data ...
Rachel K. Scott, Sharon Nachman, Ethel D. Weld, Rachel Daley, Shakir Atoyebi, Robert Bies, Catriona Waitt, Adeniyi Olagunju   +7 more
wiley   +1 more source

Olanzapine induced autophagy through suppression of NF‐κB activation in human glioma cells

CNS Neuroscience & Therapeutics, 2019
Our laboratory previously reported that olanzapine treatment inhibited growth of glioma cell lines and hypothesized that autophagy may be involved in the proliferation inhibitory effects of olanzapine.
Ying-hua Zhu, Yi-fan Zhao, Rui-Si Liu, Ya-jie Xiong, Xiao Shen, Yan Wang, Zhong-Qin Liang   +6 more
semanticscholar   +1 more source

The Relationship Between Precuneus Thickness and Psychopathology in Adolescent Females With Anorexia Nervosa

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Anorexia nervosa (AN) is a severe psychiatric disorder with structural brain alterations; however, the roles of cortical surface area (CSA) and cortical thickness (CTh) during adolescence remain unclear. Building on frequent reports of gray matter reductions in the cingulate cortex and precuneus, this study assesses CSA, CTh, and ...
Irina Jarvers, Raphael Degmayr, Alexandra Otto, Ricarda Jacob, Wilhelm Malloni, Stephanie Kandsperger, Daniel Schleicher, Angelika Ecker, Isabel Wiesinger, Christina Wendl, Mark Greenlee, Romuald Brunner   +11 more
wiley   +1 more source

Cannabis and schizophrenia [PDF]

, 2014
BACKGROUND Schizophrenia is a mental illness causing disordered beliefs, ideas and sensations. Many people with schizophrenia smoke cannabis, and it is unclear why a large proportion do so and if the effects are harmful or beneficial. It is also unclear
Gillies, Donna, Kalakouti, Eliana, Kyprianou, Katerina, McLoughlin, Benjamin C., Pushpa-Rajah, Jonathan A., Rathbone, John, Variend, Hannele   +6 more
core   +1 more source