Results 41 to 50 of about 83,412 (292)

Projections from the posterolateral olfactory amygdala to the ventral striatum: neural basis for reinforcing properties of chemical stimuli [PDF]

, 2007
Background: Vertebrates sense chemical stimuli through the olfactory receptor neurons whose axons project to the main olfactory bulb. The main projections of the olfactory bulb are directed to the olfactory cortex and olfactory amygdala (the anterior and
De la Rosa-Prieto, Carlos, Insausti, Ricardo, Lanuza, Enrique, Martínez-García, Fernando, Martínez-Marcos, Alino, Mohedano-Moriano, Alicia, Novejarque, Amparo, Pro-Sistiaga, Palma, Úbeda-Bañón, Isabel   +8 more
core   +5 more sources

Hyperhomocysteinemia induces injury in olfactory bulb neurons by downregulating Hes1 and Hes5 expression

Neural Regeneration Research, 2018
Hyperhomocysteinemia has been shown to be associated with neurodegenerative diseases; however, lesions or histological changes and mechanisms underlying homocysteine-induced injury in olfactory bulb neurons remain unclear.
Jing-wen Zhang, Bo Pang, Qi Zhao, Yue Chang, Yi-li Wang, Yi-deng Jiang, Li Jing   +6 more
doaj   +1 more source

Predicting Macrophage Spatial Localization from Single‐Cell Transcriptomes to Uncover Disease Mechanisms

Advanced Science, EarlyView.
This study presents a machine‐learning framework entitled MERLIN that infers the microanatomical localization of macrophages from single‐cell transcriptomic data in structured organs such as the kidney and brain. Applying this method to existing datasets from models of acute kidney injury and diabetic nephropathy uncovered spatially resolved insights ...
Junping Yin, Qi Mei, Hans‐Joachim Paust, Ning Song, Yu Zhao, Daniela Klaus, Melanie Eichler, Yijun Hua, Jie Qin, Weiting Cheng, Christina K. Weisheit, Veronika Lukacs‐Kornek, Isis Ludwig‐Portugall, Sibylle von Vietinghoff, Christian F. Krebs, Johanna Klughammer, Ulf Panzer, Christian Kurts, Jian Li   +18 more
wiley   +1 more source

Grafting the Olfactory Epithelium to the Olfactory Bulb [PDF]

American Journal of Rhinology & Allergy, 2009
Background Impaired olfactory function leads to a decrease in the quality of life for many patients. Surgical treatment options are limited, especially for those suffering from hyposmia or anosmia after posttraumatic injury to the olfactory nerves. Stem cells located in the olfactory epithelium (OE) have the capacity to grow new neurons, making the OE ...
Sayaka, Yagi, Richard M, Costanzo
openaire   +2 more sources

Corticofugal projections from the anterior olfactory nucleus target olfactory bulb principal cells [PDF]

, 2011
The anterior olfactory nucleus (AON) is a cortical structure reciprocally connected with the olfactory bulb (OB) and the piriform cortex. Here, using small extracellular and intracellular injections to trace the terminal projections in the OB from ...
Kurt R. Illig
core   +2 more sources

S3RL: Enhancing Spatial Single‐Cell Transcriptomics With Separable Representation Learning

Advanced Science, EarlyView.
Separable Spatial Representation Learning (S3RL) is introduced to enhance the reconstruction of spatial transcriptomic landscapes by disentangling spatial structure and gene expression semantics. By integrating multimodal inputs with graph‐based representation learning and hyperspherical prototype modeling, S3RL enables high‐fidelity spatial domain ...
Laiyi Fu, Penglei Wang, Gaoyuan Xu, Jitao Lu, Qinke Peng, Danyang Wu, Hequan Sun   +6 more
wiley   +1 more source

Greater addition of neurons to the olfactory bulb than to the cerebral cortex of eulipotyphlans but not rodents, afrotherians or primates

Frontiers in Neuroanatomy, 2014
The olfactory bulb is an evolutionarily old structure that antedates the appearance of a six-layered mammalian cerebral cortex. As such, the neuronal scaling rules that apply to scaling the mass of the olfactory bulb as a function of its number of ...
Pedro Furtado De Mattos Ribeiro, Paul eManger, Kenneth C Catania, Jon H Kaas, Suzana eHerculano-Houzel   +4 more
doaj   +1 more source

ACSL1‐Dependent Microglial Lipoimmunometabolic Reprogramming Underlies Cognitive Deficits in Alcohol Use Disorder

Advanced Science, EarlyView.
This study reveals that chronic alcohol exposure selectively upregulates ACSL1 expression in prefrontal cortical microglia, driving lipid metabolism reprogramming and lipid droplet accumulation, which activates the NLRP3 inflammasome and sustains neuroinflammation. To reverse this process, a dual‐targeted lipid nanoparticle, siACSL1@LNP‐MR, is designed
Liang Hao, Xing‐Rui Cao, Bai‐Qiang Li, Fu‐Ying Zhao, Jia‐Mei Wang, Rui‐Kang Gao, Zhi‐Peng Cao, Zhen‐Xian Du, Hua‐Qin Wang   +8 more
wiley   +1 more source

Consolidation of an olfactory memory trace in the olfactory bulb is required for learning-induced survival of adult-born neurons and long-term memory. [PDF]

PLoS ONE, 2010
BACKGROUND: It has recently been proposed that adult-born neurons in the olfactory bulb, whose survival is modulated by learning, support long-term olfactory memory.
Florence Kermen, Sébastien Sultan, Joëlle Sacquet, Nathalie Mandairon, Anne Didier   +4 more
doaj   +1 more source

Metastasizing esthesioneuroblastoma in a dog [PDF]

, 2014
A 7-year-old Afghan hound presented with a history of disorientation, loss of vision, and seizures. Magnetic resonance imaging helped identify a mass at the level of the main olfactory bulb that compressed and displaced adjacent tissues in the cribriform
Herden, Christiane, Klingler, Melanie, Schmidt, Martin J., Siudak, Krystyna   +3 more
core   +1 more source