Results 91 to 100 of about 497,866 (292)

Fumarate Hydratase Lactylation Exacerbates Traumatic Brain Injury Pathology via Mitochondrial Dysfunction and Neuroinflammation

Advanced Science, EarlyView.
Tian et al. reveal that FH K112 lactylation is elevated after TBI, leading to fumarate accumulation, mitochondrial damage, mtDNA release and amplified neuroinflammation. AARS2 and SIRT3 act as the “writer” and “eraser” for FH K112 lactylation. The peptide Pep‐K112 targeting this site alleviates brain injury, highlighting a potential therapeutic target.
Yang Tian, Shuoyao Ma, Bo Yang, Fei Gao, Hao Guo, Haixiao Liu, Xun Wu, Wenxing Cui, Jingyu Dong, Qian Lin, Yufeng Ge, Jin Ma, Jiazhen Zhao, Yongzhi Zhang, Dongzhi Xue, Jiaxin Tian, Ziwen Zhang, Kai Wang, Meng Xu, Dayun Feng, Jinpeng Zhou, Yan Qu   +21 more
wiley   +1 more source

Trajectory of olfactory cortex degeneration from normal cognition to Alzheimer's disease: Insights from multimodal neuroimaging

Neurobiology of Disease
Objective: The olfactory cortex is among the earliest brain regions affected by Alzheimer's disease (AD), with olfactory deficits frequently preceding cognitive decline.
Simin Yang, Bo Xie, Dan Liao, Yuejiao Sun, Zhuo Wang, Huimao Zhang, Yu Yang, Chunjie Guo   +7 more
doaj   +1 more source

Decoding the Neural Circuit Underlying Context‐Cue Association in Retrieval of Morphine Reward Memory

Advanced Science, EarlyView.
Contextual cues recruit the glutamatergic vCA1–dmPFC pathway to retrieve morphine reward memory by reshaping cell‐type‐specific prefrontal microcircuit activity. Distinct regulation of PV+ and SST+ interneurons defines this hippocampal–prefrontal mechanism.
Zhifeng Shi, Guangying Li, Qian Yang, Rusun Liu, Linghan Gu, Mingmei Wang, John L. Waddington, Fuhai Ji, Xuechu Zhen   +8 more
wiley   +1 more source

Brain evolution in bats (Mammalia, Chiroptera): auditory, Olfactory and Sensorimotor systems [PDF]

, 2002
Data for brain structure volumes was analysed using multiple regression to test for correlated volumetric evolution in bats (Mammalia, Chiroptera). Significant partial correlations were found between major brain subdivisions, and between structures ...
Griffiths, James Matthew
core  

Regional distribution of neocortical markers in olfactory cortex.

, 2015
+++: very dense;++: dense;+ light;cell empty: absentRegional distribution of neocortical markers in olfactory cortex.
Stephen K. Osterberg (800583), Peter C. Brunjes (800582)   +1 more
core   +1 more source

Molecular Atlas of Key Food Odorants Reveals Mixture‐Level Organization and Enables Generative Aroma Design

Advanced Science, EarlyView.
KFO‐Atlas reveals how real‐world aromas are organized as structured mixtures rather than individual molecules. Building on these principles, KFO‐Gen, a generative AI framework, designs perceptually valid aroma formulations and reconstructs meat‐like aromas exclusively from plant‐derived odorants, providing a foundation for mixture‐level studies and AI ...
Jingzhi Zhang, Huadong Xing, Antonella Di Pizio, Qinfei Ke, Xingran Kou, Dachuan Zhang   +5 more
wiley   +1 more source

Wiring olfaction: the cellular and molecular mechanisms that guide the development of synaptic connections from the nose to the cortex

Frontiers in Neuroscience, 2009
Within the central nervous system, the olfactory system fascinates by its developmental and physiological particularities, and is one of the most studied models to understand the mechanisms underlying the guidance of growing axons to their appropriate ...
Fernando De Castro
doaj   +1 more source

Olfactory Epithelium Grafts in the Cerebral Cortex: An Immunohistochemical Analysis

, 2017
Objective To develop an alternative model for studying the regenerative capacity of olfactory neurons. Study Design An immunohistochemical analysis of mouse olfactory epithelium transplanted to the cerebral cortex.
DiNardo, Laurence J., Holbrook, Eric, Costanzo, Richard M.   +2 more
core   +1 more source

Effects of lithium on electrical activity and potassium ion distribution in the vertebrate central nervous system [PDF]

, 1983
Three different regions of the vertebrate central nervous system maintained in vitro (frog spinal cord, guinea pig olfactory cortex and hippocampus) have been used to investigate how Li+ influences membrane potential, membrane resistance, action ...
H. Emmert, Ten Bruggencate, Gerrit, P. Grafe, M. M. Reddy, G. Ten Bruggencate, Grafe, Peter, Reddy, M. M., Emmert, H.   +7 more
core   +1 more source

Brain Network Dynamics of Local and Global Predictive Processing in Aging

Advanced Science, EarlyView.
Separation of concurrent whole‐brain networks in source‐reconstructed magnetoencephalography (MEG) data suggests that healthy aging reorganizes, rather than uniformly attenuates, neural responses elicited from hierarchical auditory violations. Enhanced early sensory deviance processing alongside reduced higher‐order cognitive responses suggests a large‐
Mathias Houe Andersen, Gemma Fernández‐Rubio, David R. Quiroga‐Martinez, Mattia Rosso, Mathias Klarlund, Kit Melissa Larsen, Hartwig Roman Siebner, Morten L. Kringelbach, Peter Vuust, Leonardo Bonetti   +9 more
wiley   +1 more source