Results 101 to 110 of about 477,767 (296)

Dual‐Organelle Secretome Conjugation and Organ‐Uptake Tracking (DuO‐SCOUT) Enables Deep and Sensitive Mapping of the Secreted Proteins

Advanced Science, EarlyView.
A novel dual‐organelle proximity labeling platform, DuO‐SCOUT, decodes the complex landscape of systemic organ‐organ communication by capturing both classical and unconventional secretomes. Application in metabolic models maps the adipose‐to‐brain secretory relay, identifying selective extra‐hypothalamic sites for adipose‐derived factors and expanding ...
Fenglian Yang, Rui Qian, Jiaxing Song, Xingqi Meng, Jin Young Kim, Kwok On Lai, Li Wang, Liang Zhang   +7 more
wiley   +1 more source

Circuit dynamics of the olfactory pathway during olfactory learning

Frontiers in Neural Circuits
The olfactory system plays crucial roles in perceiving and interacting with their surroundings. Previous studies have deciphered basic odor perceptions, but how information processing in the olfactory system is associated with learning and memory is ...
Yutian J. Zhang, Jason Y. Lee, Kei M. Igarashi, Kei M. Igarashi, Kei M. Igarashi, Kei M. Igarashi, Kei M. Igarashi   +6 more
doaj   +1 more source

Olfactory function in focal epilepsies: Understanding mesial temporal lobe epilepsy beyond the hippocampus

Epilepsia Open, 2019
Several lines of research have linked olfactory regions with the pathophysiology of focal epilepsies. Among those regions, the piriform cortex represents the major part of the primary olfactory cortex.
Camilo Espinosa‐Jovel, Rafael Toledano, Adolfo Jiménez‐Huete, Ángel Aledo‐Serrano, Irene García‐Morales, Pablo Campo, Antonio Gil‐Nagel   +6 more
doaj   +1 more source

A common neural scale for the subjective pleasantness of different primary rewards. [PDF]

, 2010
When an economic decision is taken, it is between goals with different values, and the values must be on the same scale. Here, we used functional MRI to search for a brain region that represents the subjective pleasantness of two different rewards on the
Grabenhorst, F, Passingham, R., D'Souza, AA, De Souza, Arun, Parris, Benjamin, Rolls, ET, Passingham, RE, Rolls, Edmund T., Parris, BA, Passingham, Richard, Grabenhorst, Fabian   +10 more
core   +1 more source

TH/TRs–COL11A2 Axis Mediates Loss of a Differentiated Astrocyte State in Hypogyrified Brains

Advanced Science, EarlyView.
Using a gyrencephalic congenital hypothyroidism pig model, this study reveals cerebral atrophy and cortical hypogyrification. Single‐cell sequencing identifies astrocytes as major TH‐responsive cells, with the COL11A2‐enriched Astro‐2 state nearly absent.
Ying Zhang, Xiao Wang, Hongyan Ma, Pengcheng Lyu, Shuangjie Tian, Ruojun Zong, Jiani Chen, Gang Ren, Yongjiang Yang, Zichen Yang, Guosong Qin, Naishi Li, Yanfang Wang, Jianwei Jiao, Jianguo Zhao   +14 more
wiley   +1 more source

Functional MRI in assessing brain cortex activation patterns in response to olfactory stimuli

Неврология, нейропсихиатрия, психосоматика
Objective: quantitative assessment of the activation areas of the cerebral cortex in women and men in response to olfactory stimuli using functional magnetic resonance imaging (fMRI).Material and methods.
M. B. Dolgushin, A. P. Demyanov, M. Yu. Martynov, A. V. Dvoryanchikov, E. A. Katunina, E. A. Malykhina, R. T. Tairova, K. A. Pritshepina, V. V. Belousov   +8 more
doaj   +1 more source

Decoding the Neural Circuit Underlying Context‐Cue Association in Retrieval of Morphine Reward Memory

Advanced Science, EarlyView.
Contextual cues recruit the glutamatergic vCA1–dmPFC pathway to retrieve morphine reward memory by reshaping cell‐type‐specific prefrontal microcircuit activity. Distinct regulation of PV+ and SST+ interneurons defines this hippocampal–prefrontal mechanism.
Zhifeng Shi, Guangying Li, Qian Yang, Rusun Liu, Linghan Gu, Mingmei Wang, John L. Waddington, Fuhai Ji, Xuechu Zhen   +8 more
wiley   +1 more source

Volume Conduction Coupling of Whisker-Evoked Cortical LFP in the Mouse Olfactory Bulb

Cell Reports, 2017
Summary: Local field potentials (LFPs) are an important measure of brain activity and have been used to address various mechanistic and behavioral questions.
Ana Parabucki, Ilan Lampl
doaj   +1 more source

Molecular Atlas of Key Food Odorants Reveals Mixture‐Level Organization and Enables Generative Aroma Design

Advanced Science, EarlyView.
KFO‐Atlas reveals how real‐world aromas are organized as structured mixtures rather than individual molecules. Building on these principles, KFO‐Gen, a generative AI framework, designs perceptually valid aroma formulations and reconstructs meat‐like aromas exclusively from plant‐derived odorants, providing a foundation for mixture‐level studies and AI ...
Jingzhi Zhang, Huadong Xing, Antonella Di Pizio, Qinfei Ke, Xingran Kou, Dachuan Zhang   +5 more
wiley   +1 more source

The Olfactory Nervous System Of Terrestrial And Aquatic Vertebrates [PDF]

, 2011
Animals in their natural milieu are surrounded by odors. These odors are rich source of information, and are perceived by sophisticated olfactory systems, that have evolved over time.
Ashiq Hussain
core