Results 101 to 110 of about 116,665 (335)

Sensory Measurements: Coordination and Standardization [PDF]

, 2015
Do sensory measurements deserve the label of “measurement”? We argue that they do. They fit with an epistemological view of measurement held in current philosophy of science, and they face the same kinds of epistemological challenges as physical ...
A Ferguson, A Keller, A Majid, A Sorowska, A-S Barwich, Ann-Sophie Barwich, BAAS, C Bushdid, C Darwin, C Sell, CH Hawkes, DA Baylor, DA Deems, DD Stettler, DT Jones, E Barkai, E Tal, E Wnuk, EAM Gamble, FF Chen, GM Shepherd, GM Shepherd, H Chang, H Chang, Hasok Chang, I Tourbier, IJ Deary, J Canales, J Lötsch, J Michell, JH Cho, JY Lettvin, KC Elliott, LB Buck, M Jones-Gotman, M Meister, M Spehr, NE Bowman, PB Sklar, PM Wise, R Axel, RA Frank, RC Gerkin, RL Doty, RL Doty, S Firestein, S Firestein, S Hecht, S Pinker, SA Klein, SS Stevens, SS Stevens, T Hummel, T Hummel, U Pace, W Bechtel, Y Oka   +56 more
core   +1 more source

Olfactory‐to‐Entorhinal Network Dysrhythmias Drive Parkinson's Cognitive Impairment Through Frequency‐Specific Oscillatory Decoupling

Advanced Science, EarlyView.
Wang et al reveal that in the olfactory system, the selective impairment of gamma‐driven Barcode features underlying early olfactory deficits, while the selective impairment of theta‐driven Barcode features underlying later cognitive deficits, further establishing cross‐network gamma oscillations in the early stage as a biomarker of later cognitive ...
Shuaishuai Wang, Zhishen Cai, Xingfeng Mao, Yixuan Zhang, Yunlong Pan, Jiawen Cheng, Xuechun Wang, Hengyi Song, Sasaki Takuya, Ming Lu, Gang Hu, Xiuxiu Liu, Yingmei Lu, Feng Han   +13 more
wiley   +1 more source

Stimulation of electro-olfactogram responses in the main olfactory epithelia by airflow depends on the type 3 adenylyl cyclase [PDF]

, 2012
Cilia of olfactory sensory neurons are the primary sensory organelles for olfaction. The detection of odorants by the main olfactory epithelium (MOE) depends on coupling of odorant receptors to the type 3 adenylyl cyclase (AC3) in olfactory cilia.
Chen, Xuanmao, Storm, Daniel R., Xia, Zhengui   +2 more
core   +2 more sources

Modulation of Olfactory Perception by Visual Cortex Stimulation [PDF]

The Journal of Neuroscience, 2012
When attempting to identify an object based on smell alone, people often visualize the perceived source of the odorant. This close association between olfactory and visual functions is supported by neuroimaging studies demonstrating activation of visual cortex during performance of purely olfactory tasks.
Jahan B, Jadauji, Jelena, Djordjevic, Johan N, Lundström, Christopher C, Pack   +3 more
openaire   +2 more sources

The Gut Microbiota Regulates Motor Deficits via Butyrate in a Gnal+/− Mouse Model of DYT25 Dystonia

Advanced Science, EarlyView.
The present study provides compelling evidence for a modulatory role of the gut microbiota in the pathology of DYT25 dystonia, and butyrate supplementation alleviates the motor deficits of dystonia in Gnal+/− mice. Abstract Dystonia is the third most common movement disorder, following essential tremor and Parkinson's disease. The underlying mechanisms
Jingya Guo, Seong‐Gook Kang, Kunlun Huang, Tao Tong   +3 more
wiley   +1 more source

Novel diagnostic tools for identifying cognitive impairment using olfactory-stimulated functional near-infrared spectroscopy: patient-level, single-group, diagnostic trial

Alzheimer’s Research & Therapy, 2022
Introduction Basic studies suggest that olfactory dysfunction and functional near-infrared spectroscopy (fNIRS) can be used as tools for the diagnosis of mild cognitive impairment (MCI); however, real-world evidence is lacking.
Jaewon Kim, Dong Keon Yon, Kyu Yeong Choi, Jang Jae Lee, Namwoo Kim, Kun Ho Lee, Jae Gwan Kim   +6 more
doaj   +1 more source

Engaging and disengaging recurrent inhibition coincides with sensing and unsensing of a sensory stimulus [PDF]

, 2017
Even simple sensory stimuli evoke neural responses that are dynamic and complex. Are the temporally patterned neural activities important for controlling the behavioral output? Here, we investigated this issue.
Altan, Ege, Barbour, Dennis L, Chen, Alex, Chen, Zhengdao, Li, Chao, Lo, Ray, Nizampatnam, Srinath, Padovano, William, Raman, Baranidharan, Saha, Debajit, Sun, Wensheng   +10 more
core   +2 more sources

Flipping the Switch: MeCP2‐Mediated Lactylation Rewires Microglial Metabolism and Inflammation via the HK2/mTOR Axis in Poststroke Neuroinflammation

Advanced Science, EarlyView.
Stroke‐induced lactate accumulation promotes p300‐mediated lactylation of methyl‐CpG binding protein 2 (MeCP2) at lysine 210, which reprograms microglial metabolism toward glycolysis and activates the hexokinase 2 (HK2)/mTOR axis. This cascade promotes proinflammatory responses and impairs neurofunctional outcomes.
Zengyu Zhang, Shanshan Huang, Yong Wang, Zhiwen Jiang, Zhuohang Liu, Chenran Wang, Rong Ji, Yiwen Yuan, Xueyu Mao, Kaicheng Yang, Huicong Niu, Yanqin Gao, Jing Zhao   +12 more
wiley   +1 more source

Wiring olfaction: the cellular and molecular mechanisms that guide the development of synaptic connections from the nose to the cortex

Frontiers in Neuroscience, 2009
Within the central nervous system, the olfactory system fascinates by its developmental and physiological particularities, and is one of the most studied models to understand the mechanisms underlying the guidance of growing axons to their appropriate ...
Fernando De Castro
doaj   +1 more source

Olfactory cortical neurons read out a relative time code in the olfactory bulb [PDF]

, 2014
Odor stimulation evokes complex spatiotemporal activity in the olfactory bulb, suggesting that the identity of activated neurons as well as the timing of their activity convey information about odors.
Haddad, Rafi, Lanjuin, Anne, Madisen, Linda, Murthy, Venkatesh N., Uchida, Naoshige, Zeng, Hongkui   +5 more
core   +1 more source