Results 101 to 110 of about 670,781 (328)

Engaging and disengaging recurrent inhibition coincides with sensing and unsensing of a sensory stimulus [PDF]

, 2017
Even simple sensory stimuli evoke neural responses that are dynamic and complex. Are the temporally patterned neural activities important for controlling the behavioral output? Here, we investigated this issue.
Altan, Ege, Barbour, Dennis L, Chen, Alex, Chen, Zhengdao, Li, Chao, Lo, Ray, Nizampatnam, Srinath, Padovano, William, Raman, Baranidharan, Saha, Debajit, Sun, Wensheng   +10 more
core   +2 more sources

Task-Demand-Dependent Neural Representation of Odor Information in the Olfactory Bulb and Posterior Piriform Cortex

Journal of Neuroscience, 2019
In awake rodents, the neural representation of olfactory information in the olfactory bulb is largely dependent on brain state and behavioral context. Learning-modified neural plasticity has been observed in mitral/tufted cells, the main output neurons ...
Dejuan Wang, Penglai Liu, Xingfeng Mao, Zheng Zhou, Tiantian Cao, Jinshan Xu, Changcheng Sun, Anan Li   +7 more
semanticscholar   +1 more source

Potentiating Cerebral Perfusion Normalizes Glymphatic Dynamics in Systemic Inflammation

Advanced Science, EarlyView.
LPS‐induced systemic inflammation increases glymphatic influx but delays cervical lymphatic drainage, accompanied by AQP4 depolarization and impaired glymphatic clearance. Enhancing cerebral blood flow via the inotropic agent levosimendan effectively restored AQP4 polarization, improving glymphatic flux and amyloid‐β clearance.
Ruoyu Zhao, Bin Sun, Pengju Wei, Yingying Sun, Qianyan He, Kejia Zhang, Jun Lu, Shoujun Zhu, Yi Yang, Zhenni Guo   +9 more
wiley   +1 more source

Microglial Deletion of Hrh4 Alleviates Alzheimer's Disease Pathologies by Enhancing Microglial Phagocytosis of Amyloid‐β and Tau

Advanced Science, EarlyView.
Histamine H4 receptor (H4R) antagonist VUF6002 mimics low‐dose X‐ray irradiation in aged Alzheimer's disease (AD) mice, enhancing microglial clearance of amyloid‐beta/hyperphosphorylated tau aggregates and restoring cognition. Microglial H4R deletion activates cAMP/TGF‐β1/Smad3 pathway, enhancing phagocytosis, while TGF‐β receptor 1 deletion abolishes ...
Yi‐Jun Xu, Tan Wu, Larry Tso‐Lun Lo, Chi‐Chiu Ko, Xin Wang, Chi Him Eddie Ma   +5 more
wiley   +1 more source

Wiring olfaction: the cellular and molecular mechanisms that guide the development of synaptic connections from the nose to the cortex

Frontiers in Neuroscience, 2009
Within the central nervous system, the olfactory system fascinates by its developmental and physiological particularities, and is one of the most studied models to understand the mechanisms underlying the guidance of growing axons to their appropriate ...
Fernando De Castro
doaj   +1 more source

Cognitive facilitation following intentional odor exposure [PDF]

, 2011
This paper reviews evidence that, in addition to incidental olfactory pollutants, intentional odor delivery can impact cognitive operations both positively and negatively.
Aggleton, Andrew J. Johnson, Araujo, Ayabe-Kanamura, Badia, Ball, Baron, Baron, Baron, Baron, Bell, Bradley, Brauchli, Burnett, Cain, Campenni, Cann, Castellanos, Chebat, Chu, Chupnik, Critchley, Davis, Diego, Ehrlichman, Engen, Epple, Field, Godden, Gottfried, Gould, Herz, Herz, Herz, Heuberger, Heuberger, Heuberger, Ho, Holland, Holmes, Hopkins, Howard, Ilmberger, Isen, Jellinek, Jirovetz, Killgore, Kim, Kim, Kim, Kirsch, Knasko, Knasko, Kuroda, Lehrner, Lis-Balchin, Lombion, Lorig, Lorig, Ludvigson, Mandairon, Marchand, Martin, McBride, Michael, Michael, Millot, Millot, Miltner, Mitchell, Moss, Moss, Moss, Murray, Norrish, Ramus, Raudenbush, Raudenbush, Roberts, Robin, Rotton, Sakamoto, Schaal, Schab, Schoenbaum, Smith, Soussignan, Soussignan, Sumner, Toda, Torii, Villemure, Villemure, Warm, Weber, Wilhelm, Wilson, Woelk, Wysocki   +98 more
core   +4 more sources

Acquisition of non-olfactory encoding improves odour discrimination in olfactory cortex [PDF]

, 2023
Noel Federman, Sebastián A. Romano, Macarena Amigo-Duran, Lucca Salomon, Antonia Marín‐Burgin   +4 more
openalex   +1 more source

Multimodal Imaging Reveals Cerebral Microcirculation Dynamics and Mechanisms in Mouse Central Nervous System After Intranasal Infection With Recombinant Pseudorabies Virus

Advanced Science, EarlyView.
Multi‐modality imaging strategy applied to PRV‐induced central nervous system infection enables dynamic visualization of cerebrovascular dysfunction, including hyperemia, hypoperfusion, and vascular remodeling. These changes are linked to microglial activation and impaired angiogenesis, providing mechanistic insight into PRV neuropathogenesis and ...
Shuting Ling, Chongxin Wu, Mengxuan Gui, Kaiyun Chen, Yanbo Yang, Jiwei Xing, Fengxian Du, Wei Liao, Luyao Yang, Zhaokui Jin, Ningshao Xia, Guosong Wang, Yixin Chen, Qingliang Zhao   +13 more
wiley   +1 more source

Multiscale Construction, Evaluation, and Application of Organoids

Advanced Science, EarlyView.
Organoids are pivotal models with transformative biomedical potential. A comprehensive multi‐scale perspective is presented, encompassing dual‐scale construction, four‐dimensional evaluation, triple‐point application, and an analysis of the current challenges faced by organoid technology, aiming to advance organoid research and its biomedical ...
Wanting Ma, Zhenglin Dong, Zhu'anzhen Zheng, Long Bai, Xingcai Zhang, Jiacan Su   +5 more
wiley   +1 more source

Trajectory of olfactory cortex degeneration from normal cognition to Alzheimer's disease: Insights from multimodal neuroimaging

Neurobiology of Disease
Objective: The olfactory cortex is among the earliest brain regions affected by Alzheimer's disease (AD), with olfactory deficits frequently preceding cognitive decline.
Simin Yang, Bo Xie, Dan Liao, Yuejiao Sun, Zhuo Wang, Huimao Zhang, Yu Yang, Chunjie Guo   +7 more
doaj   +1 more source