Results 291 to 300 of about 125,273 (334)

Gain‐of‐function enhancers optimize CAR‐NK cell‐based anti‐cancer immunotherapy

open access: yesImmunology &Cell Biology, EarlyView.
Schematic overview of the two‐stage screening approach used to identify NK cell fitness genes. (A) CRISPRa mechanism, showing dCas9‐VP64‐mediated upregulation of target genes. (B) Whole‐genome CRISPRa screening in HER2‐CAR‐NK92 cells transduced with a CRISPR sgRNA library and transferred into mice bearing HT29 tumours, followed by tumour collection and
Emma Wong   +1 more
wiley   +1 more source

The Olfactory Receptor Gene Family of Marsupials

open access: yes, 2010
Delbridge, Margaret   +2 more
openaire   +1 more source
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Olfactory receptor gene expression

Seminars in Cell & Developmental Biology, 1997
Recognition and discrimination of odorous molecules are determined by heptahelical G-protein-coupled receptor proteins localized primarily in the ciliary membrane of olfactory sensory neurons. The discovery of a large multigene family encoding odorant receptors allows us to approach various facets concerning the molecular basis of olfactory ...
H, Breer, J, Strotmann
openaire   +2 more sources

Olfactory receptor gene expression in tiger salamander olfactory epithelium

Journal of Comparative Neurology, 2004
AbstractPhysiological studies of odor‐elicited responses from the olfactory epithelium and bulb in the tiger salamander, Ambystoma tigrinum, have elucidated a number of features of olfactory coding that appear to be conserved across several vertebrate species.
James E, Marchand   +5 more
openaire   +2 more sources

Olfactory receptor gene repertoires in mammals

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2007
In mammals, olfaction is mediated by two distinct organs that are located in the nasal cavity: the main olfactory epithelium (MOE) that binds volatile odorants is responsible for the conscious perception of odors, and the vomeronasal organ (VNO) that binds pheromones is responsible for various behavioral and neuroendocrine responses between individuals
Rouquier, Sylvie, Giorgi, D.
openaire   +2 more sources

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