Results 301 to 310 of about 125,273 (334)
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Glia, 2010
AbstractOlfactory ensheathing cells (OEC) have the ability to promote regeneration in the nervous system. Hence, they hold promise for cell therapy. Most of the experimental studies have investigated the role of OECs taken from olfactory bulb (OB). However, for a clinical human application, olfactory mucosa (OM) seems to be the only acceptable source ...
Guérout, Nicolas +6 more
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AbstractOlfactory ensheathing cells (OEC) have the ability to promote regeneration in the nervous system. Hence, they hold promise for cell therapy. Most of the experimental studies have investigated the role of OECs taken from olfactory bulb (OB). However, for a clinical human application, olfactory mucosa (OM) seems to be the only acceptable source ...
Guérout, Nicolas +6 more
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Allelic inactivation regulates olfactory receptor gene expression
Cell, 1994We suggest a model in which a hierarchy of controls is exerted on the family of odorant receptor genes to assure that a sensory neuron expresses a single receptor from a family of 1000 genes. We propose that a cis-regulatory element directs the stochastic expression of only one gene from a large array of linked receptor genes.
A, Chess, I, Simon, H, Cedar, R, Axel
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OS9: A novel olfactory gene of Drosophila expressed in two olfactory organs
Journal of Neurobiology, 1994AbstractA novel olfactory gene, OS9, has been identified in Drosophila by subtractive hybridization. OS9 transcripts have been detected in the third antennal segment, the primary olfactory organ in Drosophila, and in the maxillary palp, which has recently been shown to have olfactory function.
D, Raha, J, Carlson
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Olfactory Receptor Gene Regulation
1998The mammalian olfactory system recognizes and discriminates a vast array of odorant ligands . The number of odors that can be distinguished is on the order of tens of thousands. Recognition is accomplished, initially, by members of a family of 1000 odorant receptors. Thus the olfactory system rivals the immune system in its ability to recognize a large
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The olfactory receptor gene superfamily of the mouse
Nature Neuroscience, 2002Olfactory receptor (OR) genes are the largest gene superfamily in vertebrates. We have identified the mouse OR genes from the nearly complete Celera mouse genome by a comprehensive data mining strategy. We found 1,296 mouse OR genes (including 20% pseudogenes), which can be classified into 228 families.
Xinmin, Zhang, Stuart, Firestein
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Polymorphisms in olfactory receptor genes: a cautionary note
Human Immunology, 2000The hundreds of human olfactory receptor (OR) genes are organized into clusters occurring on nearly every chromosome. Although their sequences are not always closely related, they share stretches of considerable similarity, both at the amino acid and nucleotide levels.
A, Ziegler +6 more
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Adenovirus-mediated gene transfer in olfactory neuronsin vivo
Journal of Neurobiology, 1996We used recombinant adenoviruses as a means of expressing exogenous genes in olfactory neurons in vivo. A replication incompetent adenovirus (type 5, Ad5) carrying the reporter gene lacZ, which codes for the enzyme beta-galactosidase (beta-Gal), was applied in solution to the olfactory epithelia of rats.
H, Zhao, J M, Otaki, S, Firestein
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Adenovirus-Mediated Gene Transfer in Olfactory Epithelium and Olfactory Bulb: A Long-Term Study
Annals of Otology, Rhinology & Laryngology, 2005Objectives: We sought to study the spatiotemporal gene expression mediated by adenoviral vector in the olfactory pathways. Methods: The replication-defective adenoviral vector AxCALacZ, which encodes the enzyme Escherichia coli β-galactosidase, was applied to mouse olfactory epithelium by intranasal instillation.
Kiyoshi, Doi +4 more
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Effects of olfactory bulbectomy on neuropeptide gene expression in the rat olfactory/limbic system
Neuroscience, 1998Bilateral olfactory bulbectomy in the rat produces a well-characterized syndrome that is independent of anosmia. This syndrome is reversed by chronic antidepressant administration, which provides the basis for the olfactory bulbectomy model of depression.
P V, Holmes +3 more
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Regulation of c-Fos gene expression in the rat olfactory bulb during olfactory learning
Neuroscience and Behavioral Physiology, 2007An immunohistochemical method was used to study the expression of transcription factor c-Fos in the mid part of the main olfactory bulbs in 18-day-old rats after training to seek their mothers using an olfactory orientation cue (propionic acid) in a Y-maze.
N A, Solov'eva +3 more
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