Results 81 to 90 of about 31,173 (261)

Prodromal Lewy Body Symptoms and α‐Synuclein Seeding in Idiopathic Olfactory Dysfunction

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Early identification of pathological α‐synuclein deposition (αSynD) may improve understanding of Lewy body disorder (LBD) progression and enable timely disease‐modifying treatments. Objectives We investigated αSynD using a seed amplification assay and assessed prodromal LBD symptoms in individuals with idiopathic olfactory ...
Oskar Hoffmann McWilliam, Remarh Bsoul, Gunhild Waldemar, Steen Gregers Hasselbalch, Anja Hvid Simonsen, Marie Bruun, Laura Storm Næsborg Andersen, Christian von Buchwald, Kasper Aanæs, Christian K. Pedersen, Ida S.B. Andersen, Magne Bech, Clara Hageman Pinborg, Aušrinė Areškevičiūtė, Eva Løbner Lund, Kristian Steen Frederiksen   +15 more
wiley   +1 more source

Immunological status of the olfactory bulb in a murine model of Toll-like receptor 3-mediated upper respiratory tract inflammation

Journal of Neuroinflammation, 2022
Background Postviral olfactory dysfunction (PVOD) following a viral upper respiratory tract infection (URI) is one of the most common causes of olfactory disorders, often lasting for over a year.
Ryoji Kagoya, Makiko Toma-Hirano, Junya Yamagishi, Naoyuki Matsumoto, Kenji Kondo, Ken Ito   +5 more
doaj   +1 more source

Orientation in space using the sense of smell [PDF]

, 2010
Several studies reported that respiration interacts with olfactory perception. Therefore, in the pilot study of this experiment series human breathing was investigated during an olfactory experiment.
Kleemann, Anna Maria
core  

The detection of patients at risk of gastrointestinal toxicity during pelvic radiotherapy by electronic nose and FAIMS : a pilot study [PDF]

, 2012
It is well known that the electronic nose can be used to identify differences between human health and disease for a range of disorders. We present a pilot study to investigate if the electronic nose and a newer technology, FAIMS (Field Asymmetric Ion ...
Andreyev, J., Arasaradnam, Ramesh P., Bardhan, Karna Dev, Covington, James A., Nwokolo, Chuka U., Ouaret, N., Thomas, Matthew G., Wedlake, L.   +7 more
core   +2 more sources

Outcomes in Orbit‐Sparing Versus Orbit‐Sacrificing Surgery for Sinonasal Malignancies With Orbital Involvement: A Systematic Review and Meta‐Analysis

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Background Sinonasal malignancies with orbital involvement may be managed with orbit‐sacrificing or orbit‐preserving surgical approaches, with a recent shift towards orbital preservation to reduce postoperative morbidity while maintaining oncological success.
Claire Jing‐Wen Tan, Brian Sheng Yep Yeo, Manish Warrier, Jun He Chan, Lu Hui Png, Shuhui Xu, Kimberley LiQin Kiong, Edward C. Kuan, Tze Choong Charn, Neville Wei Yang Teo   +9 more
wiley   +1 more source

SB203580, a p38MAPK inhibitor, attenuates olfactory dysfunction by inhibiting OSN apoptosis in AR mice (activation and involvement of the p38 mitogen‐activated protein kinase in olfactory sensory neuronal apoptosis of OVA‐induced allergic rhinitis)

Brain and Behavior, 2019
Objective This study aimed to investigate the effect of the p38 mitogen‐activated protein kinase (p38MAPK) signaling pathway on olfactory mucosa function and apoptosis of olfactory sensory neurons (OSNs) in an allergic rhinitis (AR) mouse model.
Xian Gao, Na Li, Jisheng Zhang
doaj   +1 more source

Odorant metabolism catalyzed by olfactory mucosal enzymes influences peripheral olfactory responses in rats. [PDF]

PLoS ONE, 2013
A large set of xenobiotic-metabolizing enzymes (XMEs), such as the cytochrome P450 monooxygenases (CYPs), esterases and transferases, are highly expressed in mammalian olfactory mucosa (OM).
Nicolas Thiebaud, Stéphanie Veloso Da Silva, Ingrid Jakob, Gilles Sicard, Joëlle Chevalier, Franck Ménétrier, Olivier Berdeaux, Yves Artur, Jean-Marie Heydel, Anne-Marie Le Bon   +9 more
doaj   +1 more source

Olfactory receptor accessory proteins play crucial roles in receptor function and gene choice [PDF]

, 2017
Each of the olfactory sensory neurons (OSNs) chooses to express a single G protein-coupled olfactory receptor (OR) from a pool of hundreds. Here, we show the receptor transporting protein (RTP) family members play a dual role in both normal OR ...
Abdus-Saboor, Aisenberg, Armelin-Correa, Aungst, Barnea, Bray, Bronson, Brunet, Buck, Carter, Chang, Chess, Col, Cowan, Dalton, Dey, Feingold, Feinstein, Feinstein, Feldmesser, Ferreira, Flegel, Gimelbrant, Gire, Godin, Griffin, Hague, Hanchate, Hayar, Ibarra-Soria, Jamet, Jia, Jiang, Kanageswaran, Kang, Kang, Khan, Kilinc, Knight, Kouadjo, Laird, Lewcock, Li, Li, Lu, Lyons, Lyons, Madisen, Magklara, Malnic, Markenscoff-Papadimitriou, Meiri, Miyamichi, Mombaerts, Nakashima, Neuhaus, Nguyen, Niimura, Omura, Pacifico, Pluznick, Pluznick, Ressler, Ressler, Robinson, Rogers, Roppolo, Saito, Salahpour, Saraiva, Serizawa, Serizawa, Shykind, Tan, Treloar, Vassar, Vassar, Verhaagen, Wang, Wang, Wei, Wong, Wu, Zhou, Zhuang, Zhuang   +85 more
core   +2 more sources

A Delphi Consensus on Clinical Features, Diagnosis, and Treatment of Chronic Rhinosinusitis With Nasal Polyps in the ASEAN Region

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Background Chronic rhinosinusitis with nasal polyps (CRSwNP) impacts patients' concentration, ability to work, and overall quality of life. Current treatment options include topical and oral medications, and surgery. Recent evidence supports the efficacy of biologics in improving symptoms and quality of life.
Baharudin Abdullah, Revadi Govindaraju, Salina Husain, Jin Keat Siow, Pongsakorn Tantilipikorn, Neville Wei Yang Teo, De Yun Wang, Deasi Anggraini, Tze Choong Charn, Chao‐Wu David Chin, Dichapong Kanjanawasee, Maung Maung Khaing, Jern‐Lin Leong, Luan Viet Tran, Harvinder Singh, Ing Ping Tang, Kim Thye Mark Thong, Gil M. Vicente, Yoke Yeow Yap, Soma Subramaniam   +19 more
wiley   +1 more source

Acetylcholine From Solitary Chemosensory Cell, Not Neuron, Regulates Basal Cell Fate Driving Eosinophilic Chronic Rhinosinusitis With Nasal Polyps

Allergy, EarlyView.
This study identifies that Ach levels are elevated in eCRSwNP and primarily released from SCCs rather than neurons. Ach induces epithelial remodeling in eCRSwNP by binding to M1R/M3R and activating YAP signaling in basal cells, driving basal cell hyperplasia and abnormal differentiation. Blocking M1R/M3R with TB inhibits eCRSwNP progression.
Bowen Zheng, Tao Lu, Ji Wang, Yalan Zhang, Panhui Xiong, Jieyu Zeng, Shuman Li, Yu Jiang, Yijun Liu, Longlan Shu, Yuan Chen, Yin Zhou, Yue Gu, Dayu Guan, Chenxi Li, Lei Zhao, Shujin Wang, Jie Liu, Xia Ke, Yang Shen, Yucheng Yang   +20 more
wiley   +1 more source