Movement Disorders Clinical Practice, EarlyView.Abstract Background Parkinson's Disease (PD) is a progressive neurodegenerative disorder primarily characterized by motor symptoms such as tremors, rigidity, and bradykinesia. Structural brain changes, including atrophy in the midbrain, basal ganglia, and cortical regions such as the frontal and temporal lobes, are observed in advanced stages.
Suraiya Mangra +5 more
wiley +1 more source
Olfactory receptor neurons are sensitive to stimulus onset asynchrony: implications for odor source discrimination. [PDF]
Chem SensesRaiser G, Galizia CG, Szyszka P.
europepmc +1 more source
Optimal compressed sensing strategies for an array of nonlinear olfactory receptor neurons with and without spontaneous activity. [PDF]
Proc Natl Acad Sci U S A, 2019 Qin S, Li Q, Tang C, Tu Y.
europepmc +1 more source
A Biomarker‐Based Classification of Corticobasal Syndrome
Movement Disorders, EarlyView.Abstract Background Corticobasal syndrome (CBS) is a clinically defined syndrome with progressive movement and cortical dysfunction, caused by various underlying pathologies, most commonly tau‐predominant pathologies such as progressive supranuclear palsy and corticobasal degeneration, or Alzheimer's disease (AD).
Carla Palleis +13 more
wiley +1 more source
Mechanism of activation and function of the odorant receptor expressed at the axon terminus-growth cone of olfactory sensory neurons [PDF]
, 2014 Sira Angela Franchi
openalex
LRRK2 as a Potential Disease‐Modifying Target in Sporadic Parkinson's Disease
Movement Disorders, EarlyView.Abstract A growing understanding of the role that leucine‐rich repeat kinase 2 (LRRK2) plays in Parkinson's disease (PD) supports continued focus on this enzyme as a therapeutic target for PD. Accumulating evidence suggests that there are phenotypic, neuropathologic, and biological similarities between sporadic PD (sPD) and familial forms in which ...
Anthony E. Lang +12 more
wiley +1 more source
Independent processing of increments and decrements in odorant concentration by ON and OFF olfactory receptor neurons. [PDF]
J Comp Physiol A Neuroethol Sens Neural Behav Physiol, 2018 Tichy H, Hellwig M.
europepmc +1 more source
Movement Disorders, EarlyView.Abstract Background Transsynaptic α‐synuclein propagation plays a crucial role in the progression of Lewy body disease. We previously demonstrated that an α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid receptor antagonist, perampanel, blocks neuronal uptake of α‐synuclein preformed fibrils (PFFs) in an activity‐dependent manner.
Jun Ueda +9 more
wiley +1 more source
Olfactory receptor neurons express olfactory marker protein but not calpain 5 from the same genomic locus. [PDF]
Mol Brain, 2019 Nakashima N +3 more
europepmc +1 more source