Results 51 to 60 of about 259,025 (282)

Transcriptional regulation of neuropeptide receptors underlies context‐dependent adaptation in Drosophila melanogaster

FEBS Open Bio, EarlyView.
Under environmental changes, the expression level of neuropeptide (NP) and neuropeptide receptor (NPR) genes changes to confer context‐dependent adaptation to the model organism Drosophila melanogaster. Through finding more regulatory elements in the NPR genes in comparison with their ligands (NPs), we found that NPR‐biased transcriptional regulation ...
SeungHeui Ryu, Yanan Wei, Zekun Wu, Tianmu Zhang, DoHoon Lee, Hadi Najafi, Woo Jae Kim   +6 more
wiley   +1 more source

Designer lipid-like peptides [PDF]

, 2011
A crucial bottleneck in membrane protein studies, particularly G-protein coupled receptors, is the notorious difficulty of finding an optimal detergent that can solubilize them and maintain their stability and function. Here we report rapid production of
Baaske, Philipp, Braun, Dieter, Brown, Emily, Corin, Karolina, Duhr, Stefan, Jerabek-Willemsen, Moran, Luo, Yuan, Ravel, Deepali B., Song, Junyao, Wang, Xiaoqiang, Wienken, Christoph J., Zhang, Shuguang   +11 more
core   +1 more source

Non-invasive aerosol delivery and transport of gold nanoparticles to the brain [PDF]

, 2017
Targeted delivery of nanoscale carriers containing packaged payloads to the central nervous system has potential use in many diagnostic and therapeutic applications. Moreover, understanding of the bio-interactions of the engineered nanoparticles used for
Biswas, Pratim, Chadha, Tandeep S, Raliya, Ramesh, Raman, Baranidharan, Saha, Debajit   +4 more
core   +2 more sources

Genetic Modifiers of Parkinson's Disease: A Case–Control Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the associations of LRRK2 p.G2019S, GBA1 p.N409S, polygenic risk scores (PRS), and APOE E4 on PD penetrance, risk, and symptoms. Methods We conducted a US‐based observational case–control study using data from the 23andMe Inc. and Fox Insight Genetic Substudy (FIGS) databases.
Matthew J. Kmiecik, Michael V. Holmes, Pierre Fontanillas, Giulietta M. Riboldi, Ruth B. Schneider, Jingchunzi Shi, Anna Guan, Susana Tat, Steven Micheletti, Keaton Stagaman, Josh Gottesman, David A. Hinds, Joyce Y. Tung, 23andMe Research Team, Stella Aslibekyan, Lucy Norcliffe‐Kaufmann   +15 more
wiley   +1 more source

Exploring Nasal Structural‐Microbial Interactions in Multiple Sclerosis‐Associated Olfactory Impairment

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Olfactory dysfunction is frequently observed in patients with multiple sclerosis (MS); however, its underlying mechanisms remain poorly understood. To date, no studies have directly examined the nasal mucosal microbiota in MS. This study aimed to explore potential relationships among olfactory function, nasal microbiota composition,
Zidan Gao, Zhuoma Danzhen, Yao Li, Junyu Zhu, Lan Chu, Zhang Yang   +5 more
wiley   +1 more source

Neuropeptide complexity in the crustacean central olfactory pathway: immunolocalization of A-type allatostatins and RFamide-like peptides in the brain of a terrestrial hermit crab

Molecular Brain, 2012
Background In the olfactory system of malacostracan crustaceans, axonal input from olfactory receptor neurons associated with aesthetascs on the animal’s first pair of antennae target primary processing centers in the median brain, the olfactory lobes ...
Polanska Marta A, Tuchina Oksana, Agricola Hans, Hansson Bill S, Harzsch Steffen   +4 more
doaj   +1 more source

Orientation in space using the sense of smell [PDF]

, 2010
Several studies reported that respiration interacts with olfactory perception. Therefore, in the pilot study of this experiment series human breathing was investigated during an olfactory experiment.
Kleemann, Anna Maria
core  

Effect of acute copper sulfate exposure on olfactory responses to amino acids and pheromones in goldfish (Carassius auratus) [PDF]

, 2009
Exposure of olfactory epithelium to environmentally relevant concentrations of copper disrupts olfaction in fish. To examine the dynamics of recovery at both functional and morphological levels after acute copper exposure, unilateral exposure of ...
Baldwin D. H., Beyers D. W., Boulay N., Carreau N. D., Chen T. G., De Boeck G., De Boeck G., Dittman A., Evans R. E., Gao X. L., Graziadei G. A., Hansen A., Hansen A., Hansen J. A., Hansen J. A., Hara T. J., Hubbard P. C., Hubbard P. C., Jennings R. A., Julliard A. K., Julliard A. K., Julliard A. K., Keller J. N., Kolmakov N. N., Konzelmann S., Kotrschal K., Mangos S., Masukawa L. M., McIntyre J. K., Moran D. T., Nair A. V., Nikonov A. A., Niyogi S., Pyle G. G., Rolen S. H., Saglio P., Sandahl J. F., Sandahl J. F., Sandahl J. F., Sato Y., Saucier D., Sloman K. A., Sorensen P., Sorensen P. W., Sorensen P. W., Stacey N., Starcevic S. L., Susankova K., Tilton F., Wang R. T., Winberg S., Zippel H. P., Zippel H. P.   +52 more
core   +2 more sources

Moyamoya Disease and the Risk of Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Moyamoya disease (MMD) is a rare cerebrovascular disorder characterized by the progressive narrowing of arteries at the base of the brain, forming abnormal collateral vascular networks. While vascular parkinsonism is noted in MMD, its link to Parkinson's disease (PD) has not been explored.
Dallah Yoo, Jeong‐Yong Shin, Rugyeom Lee, Jiwon Cheon, Ji Hun Kim, Doeun Kim, Jae‐Kyung Won, In‐Hwan Oh, Yunjong Lee, Tae‐Beom Ahn   +9 more
wiley   +1 more source

Development of a noninvasive olfactory stimulation fMRI system in marmosets

Scientific Reports
Olfactory dysfunction is associated with aging and the earliest stages of neurodegenerative diseases, such as Alzheimer’s and Parkinson’s diseases; it is thought to be an early biomarker of cognitive decline. In marmosets, a small non-human primate model
Terumi Yurimoto, Fumiko Seki, Akihiro Yamada, Junnosuke Okajima, Tomoyuki Yambe, Yoshiaki Takewa, Michiko Kamioka, Takashi Inoue, Yusuke Inoue, Erika Sasaki   +9 more
doaj   +1 more source