Results 81 to 90 of about 699 (156)
Determination of the 90% Effective Dose of Oliceridine Combined with Propofol for Day-Case Hysteroscopy. [PDF]
Drug Des Devel TherThis study employed probit regression analysis to determine the 90% effective dose (ED90) of oliceridine when combined with propofol for day-case hysteroscopy.100 patients undergoing hysteroscopic surgery were randomized to receive intravenous oliceridine (0.01, 0.015, 0.02, 0.025, or 0.03 mg kg-1) 3 minutes preoperatively.
Song CZ +6 more
europepmc +5 more sources
Opioid receptors in cardiovascular function
British Journal of Pharmacology, Volume 182, Issue 16, Page 3710-3725, August 2025.Opioid receptors are G protein‐coupled receptors expressed by various cells in the heart, including myocytes and nerve fibres, and play a crucial role in modulating cardiac function. These receptors influence neural transmission, heart rate and myocyte contractility, offering cardioprotection.
Venkatesh Katari +4 more
wiley +1 more source
Biased versus Partial Agonism in the Search for Safer Opioid Analgesics [PDF]
, 2020 Opioids such as morphine-acting at the mu opioid receptor-are the mainstay for treatment of moderate to severe pain and have good efficacy in these indications.
G Calò (9426056) +18 more
core +1 more source
A Bibliometric and Visual Analysis of Oliceridine Research (2013–2024)
Drug Design, Development and TherapyTo explore and analyze the current research progress, hotspots, and future trends in oliceridine research using bibliometric methods.We searched the Web of Science (WOS) database utilizing the keywords TS = ("oliceridine*" OR "TRV 130*" OR "TRV-130*" OR "olinvyk*" OR "TRV130*" OR "C22H31CIN2O2S*") for relevant research literature on oliceridine from ...
Cheng Song +4 more
openaire +3 more sources
Differential G protein activation by the long and short isoforms of the dopamine D2 receptor
British Journal of Pharmacology, Volume 182, Issue 14, Page 3336-3352, July 2025.Background and Purpose The dopamine D2 receptor is expressed as a short (D2S) and a long (D2L) isoform with 29 additional amino acids in the third intracellular loop. The D2S isoform shows higher presynaptic expression than the D2L isoform, and decreased D2S expression has recently been linked to an increased risk for schizophrenia.
David Reiner‐Link +4 more
wiley +1 more source
Progress on the development of Class A GPCR‐biased ligands
British Journal of Pharmacology, Volume 182, Issue 14, Page 3249-3300, July 2025.Class A G protein‐coupled receptors (GPCRs) continue to garner interest for their essential roles in cell signalling and their importance as drug targets. Although numerous drugs in the clinic target these receptors, over 60% GPCRs remain unexploited. Moreover, the adverse effects triggered by the available unbiased GPCR modulators, limit their use and
Paula Morales +20 more
wiley +1 more source
Dose Determinations at Drug Approval Reviews: FDA‐Approved Drugs in Past 5 Years
Clinical Pharmacology &Therapeutics, Volume 117, Issue 6, Page 1743-1753, June 2025.Drug dose appropriateness is one of the most discussed issues in regulatory reviews. We analyzed dose determinations during Food and Drug Administration (FDA) drug reviews to determine whether there were changes between the proposed and approved doses of new molecular entities (NMEs), including cases where postmarketing dose‐finding studies were ...
Sachiko Mita, Shunsuke Ono
wiley +1 more source
Emerging Approaches in Intravenous Moderate and Deep Sedation
, 2021 Successful pharmacological innovations that have made a difference in daily practice are rare in the world of anesthesia and sedation. After many years of research, it seems that we finally have two new drug innovations that are likely to change the ...
Keira P. Mason, Basavana Goudra
core +1 more source
New Insights Into Hepatic Impairment (HI) Trials
Clinical and Translational Science, Volume 18, Issue 1, January 2025.ABSTRACT Hepatic impairment (HI) trials are traditionally part of the clinical pharmacology development to assess the need for dose adaptation in people with impaired metabolic capacity due to their diseased liver. This review aimed at looking into the data from dedicated HI studies, cluster these data into various categories and connect the effect by ...
Sebastian Haertter +4 more
wiley +1 more source
, 2023 A free-radical cascade approach has enabled the develop-ment of a synthetically versatile alkyl–arylation of olefins. This transformation engages an excellent range of olefins, from mono- to tetrasubstituted, without requiring directing or electronically
Ayush, Sharma +5 more
core +1 more source