Results 71 to 80 of about 762 (132)

Influence of Oliceridine on the Incidence of Postoperative Nausea and Vomiting in High-Risk Patients Stratified Using Apfel Score After General Anesthesia: A Prospective, Randomized Controlled Clinical Study

Journal of Investigative Surgery
Background As a typical complication, postoperative nausea and vomiting (PONV) usually occurs among patients undergoing general anesthesia surgery, diminishing postoperative satisfaction and recovery.Objective Herein, we applied a new G-protein-biased μ ...
Xinyang Heng, Aina Xu, Yajing Xiong, Rumei Ding, Jiangfeng Zhao   +4 more
doaj   +1 more source

Clinical Applications of Oliceridine: Current Research Status, Progress, and Outlook

Oliceridine (TRV-130) is the first G protein-biased μ-opioid receptor (MOR) agonist approved by the U.S. FDA for marketing; it was approved in 2020 for the treatment of moderate-to-severe acute pain in adults.
Shizhu Lin
core   +1 more source

Biased Agonism at MOP Opioid Receptors

, 2023
Opioids are the mainstay of pain management. Their use comes with side effects such as respiratory depression, constipation, addiction and tolerance. Opioids interact with opioid receptors; classical μ (MOP), δ (DOP) and κ (KOP) and non-classical N/OFQ ...
Ammar Azzam (11718338)
core   +1 more source

Comparison of Postoperative Analgesic Efficacy of Oliceridine and Sufentanil in Total Laparoscopy Hysterectomy, a Clinical Double-Blind Controlled Trial. [PDF]

Drug Des Devel Ther
OBJECTIVE: To compare the postoperative analgesic efficacy of oliceridine versus sufentanil in patients undergoing total laparoscopy hysterectomy. METHODS: In this double-blind, randomized controlled trial, 80 patients scheduled for elective total ...
Duan J, Liu N, Lu Q, Gao W, Hou C, Liu H, Lu Y, Xu S.   +7 more
europepmc   +2 more sources

Effect of Oliceridine Combined with Sufentanil on Patient-Controlled Intravenous Analgesia in Elderly Patients After Laparoscopic Radical Resection of Rectal Cancer: A Prospective Randomized Controlled Study

Drug Design, Development and Therapy
Yifu Tian, Jiarui Hu, Haitao Pan, Guang Bai, Zhao Zhang, Peng Zhang Department of Anesthesiology, Tianjin Cancer Hospital Airport Hospital, National Clinical Research Center for Cancer, Airport Economic Zone, Tianjin, 300308, People’s Repulic of ...
Tian Y, Hu J, Pan H, Bai G, Zhang Z, Zhang P   +5 more
doaj  

Efficacy, safety, and side effects of oliceridine in acute postoperative pain, a protocol for a systematic review and meta-analysis

This will be the first meta-analysis on the efficacy, safety, and side effects of oliceridine on postoperative pain. Our aim with this work is to evaluate the clinical utility of this relatively new substance in a broad postoperative context. Oliceridine
Adamzik, Michael (Prof. Dr. med.), Witowski, Andrea Annette (Dr. med.), Unterberg, Matthias (Dr. med.), Wolf, Anne (Dr. med.), Wolf, Alexander (Dr. med.)   +4 more
core   +3 more sources

A Comparative Evaluation of the Safety and Efficacy of Oliceridine and Sufentanil in Gastrointestinal Endoscopy: A Single-Center, Randomized Controlled Trial

Drug Design, Development and Therapy
Baoyu Ma, Ying Li, Cuibo Leng, Aozhang Ji, Ning Zhang, Xinyi Tao, Qianqian Cao, Shoushi Wang Department of Anesthesiology and Perioperative Medicine, Qingdao Central Hospital, University of Health and Rehabilitation Sciences (Qingdao Central Medical ...
Ma B, Li Y, Leng C, Ji A, Zhang N, Tao X, Cao Q, Wang S   +7 more
doaj  

Estimation of ED50 and ED95 of Oliceridine Required to Suppress the Bronchoscopy Response in Patients Undergoing Fiberoptic Bronchoscopy Under Sedation with Cipepofol: An Up-and-Down Sequential Allocation Trial

Drug Design, Development and Therapy
Dongxue Wu,1,* Yeqing Liao,1,* Yanlin Qin,1,* Yafeng Wang,2 Bing Xu,3 Qiuling Chen,1 Xianting Wang,1 Xiaoshan Wu,1 Yalan Li,2 Xuehai Guan1 1Department of Anesthesiology, the First Affiliated Hospital of Guangxi Medical University,
Wu D, Liao Y, Qin Y, Wang Y, Xu B, Chen Q, Wang X, Wu X, Li Y, Guan X   +9 more
doaj  

Global Trends in Oliceridine (TRV130) Research from 2013 to 2024: A Bibliometrics and Knowledge Graph Analysis

Drug Design, Development and Therapy
Cong Wang,1 Lidan Liu,1 Xue Bai2 1Department of Anesthesiology, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, People’s Republic of China; 2Department of Health Management, Shengjing Hospital of China Medical University ...
Wang C, Liu L, Bai X
doaj  

Biased agonism of clinically approved μ-opioid receptor agonists and TRV130 is not controlled by binding and signaling kinetics

, 2020
Binding and signaling kinetics have previously proven important in validation of biased agonism at GPCRs. Here we provide a comprehensive kinetic pharmacological comparison of clinically relevant μ-opioid receptor agonists, including the novel biased ...
Pedersen, Daniel Sejer, Bouvier, Michel, Møller, Thor Christian, Bräuner-Osborne, Hans, Wrobel, Tomasz Marcin, Pedersen, Henrik, Pedersen, Mie Fabricius, Gabriele, Federica, Matosiuk, Dariusz, Foster, Simon Richard, Märcher-Rørsted, Emil   +10 more
core   +1 more source