Results 61 to 70 of about 699 (156)

Morphine‐induced mechanical hypersensitivity in mice requires δ receptors, β‐arrestin2, and c‐Src activity

The Journal of Physiology, Volume 601, Issue 8, Page 1483-1500, 15 April 2023., 2023
Abstract figure legend Administration of complete Freund's adjuvant (CFA) into one hind paw in wild‐type (WT) C57BL/6J mice led to transient mechanical hypersensitivity that ceased by day 7 and was associated with changes in the expression of mRNA transcripts encoding opioid peptides and opioid receptors. Spontaneous hypersensitivity was abolished in μ−
Samuel Singleton, Tim G. Hales
wiley   +1 more source

Efficacy and safety of oliceridine treatment in patients with postoperative pain: a systematic review and meta-analysis of randomized controlled trials

, 2023
Our aim was to conduct a systematic review and meta-analysis to examine the efficacy and safety of oliceridine in patients with postoperative pain. Four databases were searched from the beginning of the database to the present. We included all randomized
Yuntao Lu (308200), Hui Tang (226667), Jingwen Niu (538210), Wenmin Hu (9311545)   +3 more
core   +1 more source

Oliceridine for the Management of Moderate to Severe Acute Postoperative Pain: A Narrative Review

Drug Design, Development and Therapy, 2023
Despite current advances in acute postoperative pain management, prevalence remains high. Inadequate treatment could lead to poor outcomes and even progression to chronic pain. Opioids have traditionally been the mainstay for treatment of moderate to severe acute pain.
Neil Daksla, Ashley Wang, Zhaosheng Jin, Abhishek Gupta, Sergio D Bergese   +4 more
openaire   +4 more sources

Mechanism of opioid addiction and its intervention therapy: Focusing on the reward circuitry and mu‐opioid receptor

MedComm, Volume 3, Issue 3, September 2022., 2022
1. Rewarding effects and withdrawal syndrome are two dominant components of opioid addiction. 2. Mu‐opioid receptors (MORs) are highly involved in reward circuitry and the development of withdrawal syndrome. 3. MORs are important targets to treat addiction and withdrawal syndrome.
Jia‐Jia Zhang, Chang‐Geng Song, Ji‐Min Dai, Ling Li, Xiang‐Min Yang, Zhi‐Nan Chen   +5 more
wiley   +1 more source

Oliceridine is Associated with Reduced Risk of Vomiting and Need for Rescue Antiemetics Compared to Morphine: Exploratory Analysis from Two Phase 3 Randomized Placebo and Active Controlled Trials

, 2021
Use of parenteral opioids is a major risk factor for postoperative nausea and vomiting. Conventional opioids bind to µ-opioid receptors (MOR), stimulate both the G-protein signaling (achieving analgesia); and the β-arrestin pathway (associated with ...
Habib, Ashraf S, Fossler, Michael J, Rider, Paul, Wase, Linda, Michalsky, Cathy, Viscusi, Eugene R, Beard, Timothy L, Demitrack, Mark A, Candiotti, Keith A   +8 more
core   +1 more source

Oliceridine Exhibits Improved Tolerability Compared to Morphine at Equianalgesic Conditions: Exploratory Analysis from Two Phase 3 Randomized Placebo and Active Controlled Trials

, 2022
Introduction In the management of postoperative acute moderate-to-severe pain, opioids remain an important component. However, conventional opioids have a narrow therapeutic index and are associated with dose-limiting opioid-related ...
Wase, Linda, Hammer, Gregory B., Fossler, Michael J., Michalsky, Cathy, Khanna, Ashish K., Little, Roderick, Ayad, Sabry, Demitrack, Mark A.   +7 more
core   +1 more source

Oliceridine: A Novel Drug for the Management of Moderate to Severe Acute Pain – A Review of Current Evidence

Journal of Pain Research, 2021
Hon Sen Tan,1 Ashraf S Habib2 1Department of Women’s Anesthesia, KK Women’s and Children’s Hospital, 229899, Singapore; 2Department of Anesthesiology, Division of Women’s Anesthesia, Duke University Medical Center, Durham, NC ...
Tan HS, Habib AS
doaj  

Autonomic nervous system modulation by G protein-biased mu-opioid receptor agonists: A translational scoping review protocol. [PDF]

PLoS One
Background: G protein-biased mu-opioid receptor (MOR) agonists such as oliceridine and tegileridine were developed to reduce opioid-related side effects while keeping analgesic efficacy.
Zhang Y, Chen Q, Zhou Y, Zeng Q, Cui H, Zhou Y.   +5 more
europepmc   +3 more sources

Spatiotemporal dynamics of β‐arrestin‐mediated Src activation in 5‐HT7 receptor signaling pathway

The FEBS Journal, EarlyView.
GPCRs induce distinct cellular responses via G protein‐ or β‐arrestin‐mediated signaling pathways. This study revealed that β‐arrestin‐biased 5‐HT7R ligand induces slow, sustained Src activation, contrasting with transient G protein‐mediated activation.
Hyunbin Kim, Yong Woo Lee, Huimin Lee, Eunseo Park, Jieon Lee, Hae Nim Lee, Kyeong‐Man Kim, Hyunah Choo, Jihye Seong   +8 more
wiley   +1 more source

Preclinical Discovery and Development of oliceridine (Olinvyk®) for the Treatment of Post-Operative Pain

, 2021
IntroductionOpioids acting at the MOP(mu:µ) receptor produce analgesia but also side-effects. There is debate suggesting opioid receptors produce analgesia via G-protein and side-effects via β-arrestin-2 pathways.
David Lambert (504743), Ammar Azzam (11718338)   +1 more
core   +1 more source