Results 41 to 50 of about 699 (156)

Effects of Oliceridine Versus Sufentanil on Hemodynamic Stability in Elderly Hypertensive Patients During Laryngeal Mask Airway Anesthesia: A Randomized Controlled Trial [PDF]

Drug Design, Development and Therapy
Lvlv Chen,1 Kangjie Xie,2 Kuiquan Ji,1 Mingbo Long,1 Yongguo Zhang,1 Kai He1 1Department of Anesthesiology, People’s Hospital of Qiannan, Duyun, 558000, People’s Republic of China; 2Department of Anesthesiology, First Affiliated Hospital of Wenzhou ...
Chen L, Xie K, Ji K, Long M, Zhang Y, He K   +5 more
doaj   +2 more sources

Efficacy and Safety of Oliceridine for Patient-Controlled Intravenous Analgesia in Elderly Patients Undergoing Laparoscopic Radical Resection Surgery for Gastrointestinal Malignant Tumors: A Prospective Randomized Controlled Non-Inferiority Clinical Trial [PDF]

Drug Design, Development and Therapy
Jiameng Wang,* Yue Shang,* Chenyang Wang, Dongdong Zhang, Han Li, Qian Yu, Lei Tao, Li Sun, Changjun Gao Department of Anesthesiology, Tangdu Hospital, The Fourth Military Medical University, Xi’an, 710038, People’s Republic of China& ...
Wang J, Shang Y, Wang C, Zhang D, Li H, Yu Q, Tao L, Sun L, Gao C   +8 more
doaj   +2 more sources

Evaluating the Opioid-Related Adverse Events of Oliceridine Versus Conventional Opioids in Patient-Controlled Analgesia After Thoracoscopic Lung Resection: A Retrospective Cohort Study [PDF]

Drug Design, Development and Therapy
Chengya Huang,* Biying Liu,* Shouyu Xie, Yunyun Zhang, Kun Liu, Yuwei Qiu, Jingxiang Wu Department of Anesthesiology, Shanghai Chest Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, 200030, People’s Republic of China&
Huang C, Liu B, Xie S, Zhang Y, Liu K, Qiu Y, Wu J   +6 more
doaj   +2 more sources

APOLLO-1: a randomized placebo and active-controlled phase III study investigating oliceridine (TRV130), a G protein-biased ligand at the µ-opioid receptor, for management of moderate-to-severe acute pain following bunionectomy

Journal of Pain Research, 2019
Eugene R Viscusi,1 Franck Skobieranda,2 David G Soergel,2 Emily Cook,2 David A Burt,2 Neil Singla3 1Department of Anesthesiology, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA, USA; 2Trevena Inc., Chesterbrook, PA, USA ...
Viscusi ER, Skobieranda F, Soergel DG, Cook E, Burt DA, Singla N   +5 more
doaj   +1 more source

Comparison of Oliceridine to Remifentanil for Optimal Analgesia in Mechanical Ventilation (CO-ROAM): Study Protocol for a Multicenter Randomized Controlled Trial

Pain and Therapy
Introduction Critically ill patients often endure pain, a distressing experience that can trigger diverse pathophysiological consequences. While remifentanil, with its rapid kinetics, is commonly used for analgesia in intensive care units (ICU), it ...
Jing-chao Luo, Sen Lu, Xi-liang Fu, Jun Shen, Hong-li He, Chun Pan, Xiao-bo Huang   +6 more
doaj   +2 more sources

Pharmacological Characters of Oliceridine, a μ-Opioid Receptor G-Protein–Biased Ligand in Mice

Anesthesia & Analgesia, 2019
BACKGROUND: A major advancement in the field of analgesic pharmacology has been the development of G-protein–biased opioid agonists that display less respiratory depression than conventional drugs. It is uncertain, however, whether these new drugs cause less tolerance, hyperalgesia, and other maladaptations when administered ...
Liang, De-Yong, Li, Wen-Wu, Nwaneshiudu, Chinwe, Irvine, Karen-Amanda, Clark, J. David   +4 more
openaire   +5 more sources

ATHENA: A Phase 3, Open-Label Study Of The Safety And Effectiveness Of Oliceridine (TRV130), A G-Protein Selective Agonist At The μ-Opioid Receptor, In Patients With Moderate To Severe Acute Pain Requiring Parenteral Opioid Therapy [PDF]

Journal of Pain Research, 2019
Sergio D Bergese,1 Marek Brzezinski,2 Gregory B Hammer,3 Timothy L Beard,4 Peter H Pan,5 Sharon E Mace,6 Richard D Berkowitz,7 Kristina Cochrane,8 Linda Wase,8 Harold S Minkowitz,9 Ashraf S Habib10 1School of Medicine, Stony Brook University, Stony Brook,
Bergese SD, Brzezinski M, Hammer GB, Beard TL, Pan PH, Mace SE, Berkowitz RD, Cochrane K, Wase L, Minkowitz HS, Habib AS   +10 more
doaj   +2 more sources

Effects of Oliceridine Versus Sufentanil on Postoperative Recovery Quality During Hysteroscopy Under Laryngeal Mask Airway Anesthesia: Protocol for a Single-Blind and Randomized Controlled Trial [PDF]

JMIR Research Protocols
BackgroundHysteroscopy, the gold standard for diagnosing and treating intrauterine pathologies, has shown substantial increase in its adoption in clinical practice. Nevertheless, early postoperative pain and opioid-related adverse
YuHang Shou, JianSheng Luo, XianJie Zhang, WenHu Zhai, Jia Han   +4 more
doaj   +2 more sources

Pharmacokinetics and Safety of Oliceridine Fumarate Injection in Chinese Patients with Chronic Non-Cancer Pain: A Phase I, Single-Ascending-Dose, Open-Label Clinical Trial

Drug Design, Development and Therapy
Yuncheng Ni,1,* Ranglang Huang,2,* Shuang Yang,3 Xiao Yan Yang,3 Shan Zeng,3 An Yao,3 Jie Huang,3 Guoping Yang3,4 1Department of Pain, The Third Xiangya Hospital and Institute of Pain Medicine, Central South University, Changsha, Hunan, 410013 ...
Ni Y, Huang R, Yang S, Yang XY, Zeng S, Yao A, Huang J, Yang G   +7 more
doaj   +2 more sources

Comparison of oliceridine and fentanyl intraoperative analgesia on postoperative nausea and vomiting in female patients undergoing laparoscopic cholecystectomy: study protocol for a randomized, double-blind, controlled trial [PDF]

Trials
Background Postoperative nausea and vomiting (PONV) is significantly associated with intraoperative opioid use. Oliceridine, a μ-opioid receptor agonist with G protein bias, exhibits fewer opioid-related adverse events (ORAEs) than morphine.
Fangsheng Xu, Yuanyuan Cui, Zhengle Wang, Feng Wu, Wei Zhang, Rongguang Liu, Yuan Xu, Jian Tang, Jianfeng Pu, Meifang Wang   +9 more
doaj   +2 more sources