Results 41 to 50 of about 762 (132)

Benefit and risk evaluation of biased mu-receptor agonist oliceridine versus morphine [PDF]

, 2020
Background: To improve understanding of the respiratory behavior of oliceridine, a mu-opioid receptor agonist that selectively engages the G-protein-coupled signaling pathway with reduced activation of the beta-arrestin pathway, the authors compared its ...
Dam, C.J. van, Velzen, M. van, Niesters, M., Fossler, M.J., Dahan, A., Demitrack, M.A., Olofsen, E.   +6 more
core   +1 more source

A systematic review of opioid use and multimodal strategies in solid organ transplant recipients and living donors

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 43, Issue 6, Page 514-551, June 2023., 2023
Abstract The opioid epidemic has impacted analgesia in the postoperative period for solid organ transplant (SOT) donors and recipients. However, optimal pain management and opioid stewardship strategies have not been identified across this unique population.
Heather L. Kutzler, Alicia B. Lichvar, David Quan, Lyndsey J. Bowman, Adam Diamond, Christina Doligalski, Tina Griffin, Jennifer Melaragno, Helen Sweiss, James Fleming   +9 more
wiley   +1 more source

Oral Oxycodone‐Induced Respiratory Depression During Normocapnia and Hypercapnia: A Pharmacokinetic‐Pharmacodynamic Modeling Study

Clinical Pharmacology &Therapeutics, Volume 113, Issue 5, Page 1080-1088, May 2023., 2023
The widely prescribed opioid oxycodone may cause lethal respiratory depression. We compared the effects of oxycodone on breathing and antinociception in healthy young volunteers. After pharmacokinetic/pharmacodynamic (PK/PD) modeling, we constructed utility functions to combine the wanted and unwanted end points into a single function.
Marieke Hellinga, Marijke Hyke Algera, Erik Olofsen, Rutger van der Schrier, Elise Sarton, Monique van Velzen, Albert Dahan, Marieke Niesters   +7 more
wiley   +1 more source

Efficacy and safety of oliceridine versus sufentanil for patient-controlled intravenous analgesia following gynecological laparoscopic surgery: a randomized, double-blind, parallel-group trial. [PDF]

Front Med (Lausanne)
Background To compare the efficacy and incidence of adverse reactions of oliceridine versus sufentanil in patient-controlled intravenous analgesia (PCIA) for postoperative pain management following gynecological ...
Zhou J, Wu Z, Lai Y, Shi J, Chen W, Wu Z, Guo X, Li M, Jiang X, Zhuang S, Huang R, Ke W.   +11 more
europepmc   +2 more sources

Morphine‐induced mechanical hypersensitivity in mice requires δ receptors, β‐arrestin2, and c‐Src activity

The Journal of Physiology, Volume 601, Issue 8, Page 1483-1500, 15 April 2023., 2023
Abstract figure legend Administration of complete Freund's adjuvant (CFA) into one hind paw in wild‐type (WT) C57BL/6J mice led to transient mechanical hypersensitivity that ceased by day 7 and was associated with changes in the expression of mRNA transcripts encoding opioid peptides and opioid receptors. Spontaneous hypersensitivity was abolished in μ−
Samuel Singleton, Tim G. Hales
wiley   +1 more source

Supplementary materials: Cost–effectiveness and cost–benefit analysis of oliceridine in the treatment of acute pain

, 2021
These are peer-reviewed supplementary tables for the article 'Cost–effectiveness and cost-benefit analysis of oliceridine in the treatment of acute pain' published in the Journal of Comparative Effectiveness Research.Supplementary Table 1. Estimated mean
Linda Wase (9569954), Kit N. Simpson (10760663), Mark A. Demitrack (9569957), Michael J. Fossler (6945680)   +3 more
core   +1 more source

PBPK-Based Prediction of Oliceridine Exposure in Breast Milk and Relative Infant Dose During the First 24 h After Cesarean Delivery. [PDF]

J Clin Pharmacol
Oliceridine is an intravenous opioid analgesic for postoperative pain control, but data on transfer into human milk and infant exposure during early breastfeeding remain limited.
Ding Y, Liu K, Zhang S, Zhang Y, Tan X, Xu W.   +5 more
europepmc   +2 more sources

Efficacy and safety of oliceridine treatment in patients with postoperative pain: a systematic review and meta-analysis of randomized controlled trials

, 2023
Our aim was to conduct a systematic review and meta-analysis to examine the efficacy and safety of oliceridine in patients with postoperative pain. Four databases were searched from the beginning of the database to the present. We included all randomized
Yuntao Lu (308200), Hui Tang (226667), Jingwen Niu (538210), Wenmin Hu (9311545)   +3 more
core   +1 more source

Oliceridine is Associated with Reduced Risk of Vomiting and Need for Rescue Antiemetics Compared to Morphine: Exploratory Analysis from Two Phase 3 Randomized Placebo and Active Controlled Trials

, 2021
Use of parenteral opioids is a major risk factor for postoperative nausea and vomiting. Conventional opioids bind to µ-opioid receptors (MOR), stimulate both the G-protein signaling (achieving analgesia); and the β-arrestin pathway (associated with ...
Habib, Ashraf S, Fossler, Michael J, Rider, Paul, Wase, Linda, Michalsky, Cathy, Viscusi, Eugene R, Beard, Timothy L, Demitrack, Mark A, Candiotti, Keith A   +8 more
core   +1 more source

Oliceridine: A Novel Drug for the Management of Moderate to Severe Acute Pain – A Review of Current Evidence

Journal of Pain Research, 2021
Hon Sen Tan,1 Ashraf S Habib2 1Department of Women’s Anesthesia, KK Women’s and Children’s Hospital, 229899, Singapore; 2Department of Anesthesiology, Division of Women’s Anesthesia, Duke University Medical Center, Durham, NC ...
Tan HS, Habib AS
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