Results 31 to 40 of about 762 (132)

A Bibliometric and Visual Analysis of Oliceridine Research (2013–2024)

Drug Design, Development and Therapy
Cheng Song,1,* Xinxing Huang,2,* Nianping Chen,1 Qiliang Song,3 Yuanli Qiu1 1Department of Anesthesiology, Affiliated Hospital of Shaoxing University, Zhejiang, 312000, People’s Republic of China; 2Department of Anesthesiology, Jinhua Maternal ...
Song C, Huang X, Chen N, Song Q, Qiu Y
doaj   +1 more source

Preclinical Discovery and Development of oliceridine (Olinvyk®) for the Treatment of Post-Operative Pain

, 2021
IntroductionOpioids acting at the MOP(mu:µ) receptor produce analgesia but also side-effects. There is debate suggesting opioid receptors produce analgesia via G-protein and side-effects via β-arrestin-2 pathways.
David Lambert (504743), Ammar Azzam (11718338)   +1 more
core   +7 more sources

APOLLO-1: a randomized placebo and active-controlled phase III study investigating oliceridine (TRV130), a G protein-biased ligand at the µ-opioid receptor, for management of moderate-to-severe acute pain following bunionectomy

Journal of Pain Research, 2019
Eugene R Viscusi,1 Franck Skobieranda,2 David G Soergel,2 Emily Cook,2 David A Burt,2 Neil Singla3 1Department of Anesthesiology, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA, USA; 2Trevena Inc., Chesterbrook, PA, USA ...
Viscusi ER, Skobieranda F, Soergel DG, Cook E, Burt DA, Singla N   +5 more
doaj   +1 more source

Pharmacokinetics and Safety of Oliceridine Fumarate Injection in Chinese Patients with Chronic Non-Cancer Pain: A Phase I, Single-Ascending-Dose, Open-Label Clinical Trial [PDF]

Drug Design, Development and Therapy
Yuncheng Ni,1,* Ranglang Huang,2,* Shuang Yang,3 Xiao Yan Yang,3 Shan Zeng,3 An Yao,3 Jie Huang,3 Guoping Yang3,4 1Department of Pain, The Third Xiangya Hospital and Institute of Pain Medicine, Central South University, Changsha, Hunan, 410013 ...
Ni Y, Huang R, Yang S, Yang XY, Zeng S, Yao A, Huang J, Yang G   +7 more
doaj   +1 more source

Effect of oliceridine pretreatment on etomidate-induced myoclonus: a prospective, randomized, double-blind, controlled study [PDF]

Frontiers in Medicine
PurposeEtomidate often induces adverse effects such as myoclonus during anesthesia induction, thereby increasing perioperative risks for patients to some extent. Oliceridine is a novel opioid with fewer opioid-related adverse reactions.
Qingqing Sun, Xiaoqian Wang, Ziyuan Chen, Guimin Dong, Xinyuan Shi, Shiyu Yu, Hongyi Xiao, Fanceng Ji   +7 more
doaj   +2 more sources

Efficacy and Safety of Oliceridine for Patient-Controlled Intravenous Analgesia in Elderly Patients Undergoing Laparoscopic Radical Resection Surgery for Gastrointestinal Malignant Tumors: A Prospective Randomized Controlled Non-Inferiority Clinical Trial [PDF]

Drug Design, Development and Therapy
Jiameng Wang,* Yue Shang,* Chenyang Wang, Dongdong Zhang, Han Li, Qian Yu, Lei Tao, Li Sun, Changjun Gao Department of Anesthesiology, Tangdu Hospital, The Fourth Military Medical University, Xi’an, 710038, People’s Republic of China& ...
Wang J, Shang Y, Wang C, Zhang D, Li H, Yu Q, Tao L, Sun L, Gao C   +8 more
doaj   +2 more sources

Comparison of Oliceridine to Remifentanil for Optimal Analgesia in Mechanical Ventilation (CO-ROAM): Study Protocol for a Multicenter Randomized Controlled Trial

Pain and Therapy
Introduction Critically ill patients often endure pain, a distressing experience that can trigger diverse pathophysiological consequences. While remifentanil, with its rapid kinetics, is commonly used for analgesia in intensive care units (ICU), it ...
Jing-chao Luo, Sen Lu, Xi-liang Fu, Jun Shen, Hong-li He, Chun Pan, Xiao-bo Huang   +6 more
doaj   +2 more sources

ATHENA: A Phase 3, Open-Label Study Of The Safety And Effectiveness Of Oliceridine (TRV130), A G-Protein Selective Agonist At The μ-Opioid Receptor, In Patients With Moderate To Severe Acute Pain Requiring Parenteral Opioid Therapy [PDF]

Journal of Pain Research, 2019
Sergio D Bergese,1 Marek Brzezinski,2 Gregory B Hammer,3 Timothy L Beard,4 Peter H Pan,5 Sharon E Mace,6 Richard D Berkowitz,7 Kristina Cochrane,8 Linda Wase,8 Harold S Minkowitz,9 Ashraf S Habib10 1School of Medicine, Stony Brook University, Stony Brook,
Bergese SD, Brzezinski M, Hammer GB, Beard TL, Pan PH, Mace SE, Berkowitz RD, Cochrane K, Wase L, Minkowitz HS, Habib AS   +10 more
doaj   +2 more sources

Respiratory effects of biased ligand oliceridine in older volunteers: a pharmacokinetic-pharmacodynamic comparison with morphine [PDF]

, 2023
Background: Oliceridine is a G protein–biased μ-opioid, a drug class thatis associated with less respiratory depression than nonbiased opioids, suchas morphine.
Velzen, M. van, Niesters, M., Jansen, S., Dahan, A., Demitrack, M.A., Michalsky, C., Sarton, E., Schrier, R. van der, Kuijpers, K.W.K., Nicklas, T., Simons, P., Lemmen, M. van, Fossler, M., Olofsen, E.   +13 more
core   +1 more source

Overview and Prospects of the Clinical Application of Oliceridine

Drug Design, Development and Therapy
Kun Yi,* Wenjie Sun,* Wen Yu, Shibiao Chen Department of Anesthesiology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, People’s Republic of China*These authors contributed
Shibiao Chen
exaly   +2 more sources