Results 11 to 20 of about 699 (156)

Oliceridine as a Novel Selective mu-receptor G-protein Pathway Modulator: A Narrative review [PDF]

Perspectives In Medical Research, 2021
Objective: To review the literature on equianalgesic efficacy and better safety(less respiratory depression and gastrointestinal dysfunction) of oliceridine versus opioid analgesic in moderate to severe postoperative pain.
Uma Advani, Ravi Prakash, Parmanand Swami, Neha Sharma, Charu Jain, Monica Jain   +5 more
doaj   +3 more sources

Gastrointestinal adverse effects associated with the use of intravenous oliceridine compared with intravenous hydromorphone or fentanyl in acute pain management utilizing adjusted indirect treatment comparison methods

Journal of Comparative Effectiveness Research
Background: In the absence of head-to-head comparative data from randomized controlled trials, indirect treatment comparisons (ITCs) may be used to compare the relative effects of treatments versus a common comparator (either placebo or active ...
Gary Oderda, Diana Brixner, Todd L Wandstrat   +2 more
exaly   +3 more sources

Determination of the effective dose of oliceridine combined with propofol using the modified Dixon’s up-and-down method in painless gastroscopy [PDF]

Frontiers in Pharmacology
ObjectiveTo investigate the median effective dose (ED50) and 95% effective dose (ED95) of oliceridine combined with propofol for painless gastroscopy in adults.MethodsPatients underwent painless gastroscopy were divided to male and female cohorts.
Jinfeng Cao, Xiaoyu Gu, Xinyang Zhang, Yao Cheng, Liuqin Jiang   +4 more
doaj   +4 more sources

Low Incidence of Postoperative Respiratory Depression with Oliceridine Compared to Morphine: A Retrospective Chart Analysis [PDF]

Pain Research and Management, 2020
Background. Oliceridine, an investigational IV opioid, is a first-in-class G-protein selective agonist at the μ-opioid receptor. The G-protein selectivity results in potent analgesia with less recruitment of β-arrestin, a signaling pathway associated ...
Sergio Bergese, Richard Berkowitz, Paul Rider, Martin Ladouceur, Suzanne Griffith, Alvaro Segura Vasi, Kristina Cochrane, Linda Wase, Mark A. Demitrack, Ashraf S. Habib   +9 more
doaj   +4 more sources

Overview and Prospects of the Clinical Application of Oliceridine [PDF]

Drug Design, Development and Therapy
Kun Yi,* Wenjie Sun,* Wen Yu, Shibiao Chen Department of Anesthesiology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, People’s Republic of China*These authors contributed
Yi K, Sun W, Yu W, Chen S
doaj   +4 more sources

Estimation of median effective doses and 95% effective doses of oliceridine combined with propofol for day-case hysteroscopy under total intravenous anesthesia with preserved spontaneous breathing: an up-and-down sequential allocation trial [PDF]

BMC Anesthesiology
Background Oliceridine is a novel developed G protein-biased µ-opioid receptor agonist, offering a significant reduction in the risk of opioid-related respiratory depression and a lower incidence of gastrointestinal adverse effects.
Jiliang He, Yijun Ma, Keyi Wang, Hao Zhou, Ce Chen, Mengjun Chen, Zhongen Shen, Weifeng Gao   +7 more
doaj   +3 more sources

The median effective dose of esketamine with different doses of oliceridine during hysteroscopic surgery [PDF]

Frontiers in Pharmacology
PurposeThis study aimed to investigate the impact of different doses of oliceridine on the ED50 of esketamine during hysteroscopic surgery. The objective was to establish an optimal dosing regimen that facilitates the development of an effective and safe
Min Shi, Tong Wang, Weiwei Wang, Jiafeng Wang, Lulu Li, Lulong Bo, Xiaolin Wang   +6 more
doaj   +4 more sources

A Bibliometric and Visual Analysis of Oliceridine Research (2013–2024)

Drug Design, Development and Therapy
Cheng Song,1,* Xinxing Huang,2,* Nianping Chen,1 Qiliang Song,3 Yuanli Qiu1 1Department of Anesthesiology, Affiliated Hospital of Shaoxing University, Zhejiang, 312000, People’s Republic of China; 2Department of Anesthesiology, Jinhua Maternal ...
Song C, Huang X, Chen N, Song Q, Qiu Y
doaj   +2 more sources

Respiratory Effects of Biased Ligand Oliceridine in Older Volunteers: A Pharmacokinetic–Pharmacodynamic Comparison with Morphine

Anesthesiology, 2022
Background Oliceridine is a G protein–biased µ-opioid, a drug class that is associated with less respiratory depression than nonbiased opioids, such as morphine. The authors quantified the respiratory effects of oliceridine and morphine in elderly volunteers.
Simons, P., Schrier, R. van der, Lemmen, M. van, Jansen, S., Kuijpers, K.W.K., Velzen, M. van, Sarton, E., Nicklas, T., Michalsky, C., Demitrack, M.A., Fossler, M., Olofsen, E., Niesters, M., Dahan, A.   +13 more
openaire   +5 more sources

Journey of Oliceridine: A Novel Opioid

Journal of Marine Medical Society, 2022
Opioid analgesics play a crucial role in the management of acute pain, but its use is often limited by various adverse effects, especially nausea, vomiting, and respiratory depression.
A Tejus, Sharmila Sinha, Prafull Mohan, A G Mathur   +3 more
doaj   +2 more sources