Results 11 to 20 of about 762 (132)

Oliceridine as a Novel Selective mu-receptor G-protein Pathway Modulator: A Narrative review [PDF]

Perspectives In Medical Research, 2021
Objective: To review the literature on equianalgesic efficacy and better safety(less respiratory depression and gastrointestinal dysfunction) of oliceridine versus opioid analgesic in moderate to severe postoperative pain.
doaj   +2 more sources

Low Incidence of Postoperative Respiratory Depression with Oliceridine Compared to Morphine: A Retrospective Chart Analysis

Pain Research and Management, 2020
Background. Oliceridine, an investigational IV opioid, is a first-in-class G-protein selective agonist at the μ-opioid receptor. The G-protein selectivity results in potent analgesia with less recruitment of β-arrestin, a signaling pathway associated ...
Sergio Bergese, Richard Berkowitz, Paul Rider, Martin Ladouceur, Suzanne Griffith, Alvaro Segura Vasi, Kristina Cochrane, Linda Wase, Mark A. Demitrack, Ashraf S. Habib   +9 more
doaj   +2 more sources

A randomized, Phase IIb study investigating oliceridine (TRV130), a novel µ-receptor G-protein pathway selective (µ-GPS) modulator, for the management of moderate to severe acute pain following abdominoplasty

Journal of Pain Research, 2017
Neil Singla,1 Harold S Minkowitz,2 David G Soergel,3 David A Burt,3 Ruth Ann Subach,3 Monica Y Salamea,3 Michael J Fossler,3 Franck Skobieranda3 1Lotus Clinical Research, Pasadena, CA, 2Memorial Hermann Memorial City Medical Center, Houston, TX, 3Trevena,
Singla N, Minkowitz HS, Soergel DG, Burt DA, Subach RA, Salamea MY, Fossler MJ, Skobieranda F   +7 more
doaj   +1 more source

Gastrointestinal adverse effects associated with the use of intravenous oliceridine compared with intravenous hydromorphone or fentanyl in acute pain management utilizing adjusted indirect treatment comparison methods

Journal of Comparative Effectiveness Research
Background: In the absence of head-to-head comparative data from randomized controlled trials, indirect treatment comparisons (ITCs) may be used to compare the relative effects of treatments versus a common comparator (either placebo or active ...
Joseph Biskupiak, Gary Oderda, Diana Brixner, Todd L Wandstrat   +3 more
doaj   +2 more sources

Assessment of the potential of novel and classical opioids to induce respiratory depression in mice [PDF]

British Journal of Pharmacology, Volume 180, Issue 24, Page 3160-3174, December 2023., 2023
Abstract Background and Purpose Opioid‐induced respiratory depression limits the use of μ‐opioid receptor agonists in clinical settings and is the main cause of opioid overdose fatalities. The relative potential of different opioid agonists to induce respiratory depression at doses exceeding those producing analgesia is understudied despite its ...
Rob Hill, Julie Sanchez, Laura Lemel, Mirjana Antonijevic, Yselkla Hosking, Shailesh N. Mistry, Andrew C. Kruegel, Jonathan A. Javitch, J. Robert Lane, Meritxell Canals   +9 more
wiley   +2 more sources

Estimation of ED50 and ED95 of oliceridine required to suppress bronchoscopic responses during remimazolam sedation: study protocol for an up-and-down sequential allocation trial [PDF]

BMJ Open
Background Flexible bronchoscopy frequently provokes airway reflexes that impair patient comfort and procedural quality. Remimazolam provides effective sedation but often requires adjunctive opioids to suppress coughing and movement.
Ke Jiang, Anhong Li, Yuancheng Zhou, Xueying Zhou, Bailong Hu   +4 more
doaj   +2 more sources

Efficacy and safety of Oliceridine versus Sufentanil in postoperative analgesia for burn skin grafting: a machine learning and SHAP-based cohort study [PDF]

Frontiers in Medicine
BackgroundBalancing profound analgesia with the minimization of opioid-related adverse events, particularly postoperative nausea and vomiting (PONV), remains challenging in burn surgery.
Ye Tian, Yun Zhang, Danshi Feng, Hongying Wang, Zihuan Ma   +4 more
doaj   +2 more sources

Hyperactivity in Mice Induced by Opioid Agonists with Partial Intrinsic Efficacy and Biased Agonism Administered Alone and in Combination with Morphine

Biomolecules, 2023
Opioid analgesics such as morphine and fentanyl induce mu-opioid receptor (MOR)-mediated hyperactivity in mice. Herein, we show that morphine, fentanyl, SR-17018, and oliceridine have submaximal intrinsic efficacy in the mouse striatum using 35S-GTPγS ...
Agnes Acevedo-Canabal, Travis W. Grim, Cullen L. Schmid, Nina McFague, Edward L. Stahl, Nicole M. Kennedy, Thomas D. Bannister, Laura M. Bohn   +7 more
doaj   +2 more sources

Nausea and vomiting as adverse events of oliceridine: a systematic review and meta-analysis of randomized controlled trials [PDF]

Frontiers in Pharmacology
BackgroundPostoperative nausea and vomiting (PONV) continue to be some of the most common and troublesome complications following anesthesia. Oliceridine, a G protein-biased µ-opioid receptor agonist, has the potential to provide effective pain relief ...
Jinfang Zeng, Shu Yang, Shu Yang, Jinjin Jian, Minmin Zhu   +4 more
doaj   +2 more sources

Effect of Oliceridine Fumarate for Patient-Controlled Intravenous Analgesia on Gastrointestinal Function in Laparoscopic Radical Gastrectomy Surgery: A Randomized, Double-Blind, Controlled Trial [PDF]

Drug Design, Development and Therapy
Chen Wang,1,2,* Wang-Dong Xu,1,2,* Xin-Lei Lu,2 Wei-Ping Lei,2 Jian-Liang Sun,1,2 Ya-Qin Huang2 1The Fourth School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou First People’s Hospital, Hangzhou, Zhejiang, 310006 ...
Wang C, Xu WD, Lu XL, Lei WP, Sun JL, Huang YQ   +5 more
doaj   +2 more sources