Results 21 to 30 of about 699 (156)

Oliceridine for Analgesia in Elderly Patients Undergoing Kyphoplasty: From a Clinical Trial. [PDF]

Pain Res Manag
Background As a G protein‐biased μ‐opioid receptor agonist, oliceridine can offer a relatively effective and safe analgesia. However, its effect on patients suffering from kyphoplasty was unexplored.
Miao C, Weng D, Liu C, Huang Q, Chen K, Zou B.   +5 more
europepmc   +3 more sources

Assessment of the potential of novel and classical opioids to induce respiratory depression in mice

British Journal of Pharmacology, Volume 180, Issue 24, Page 3160-3174, December 2023., 2023
Abstract Background and Purpose Opioid‐induced respiratory depression limits the use of μ‐opioid receptor agonists in clinical settings and is the main cause of opioid overdose fatalities. The relative potential of different opioid agonists to induce respiratory depression at doses exceeding those producing analgesia is understudied despite its ...
Rob Hill, Julie Sanchez, Laura Lemel, Mirjana Antonijevic, Yselkla Hosking, Shailesh N. Mistry, Andrew C. Kruegel, Jonathan A. Javitch, J. Robert Lane, Meritxell Canals   +9 more
wiley   +3 more sources

A randomized, Phase IIb study investigating oliceridine (TRV130), a novel µ-receptor G-protein pathway selective (µ-GPS) modulator, for the management of moderate to severe acute pain following abdominoplasty

Journal of Pain Research, 2017
Neil Singla,1 Harold S Minkowitz,2 David G Soergel,3 David A Burt,3 Ruth Ann Subach,3 Monica Y Salamea,3 Michael J Fossler,3 Franck Skobieranda3 1Lotus Clinical Research, Pasadena, CA, 2Memorial Hermann Memorial City Medical Center, Houston, TX, 3Trevena,
Singla N, Minkowitz HS, Soergel DG, Burt DA, Subach RA, Salamea MY, Fossler MJ, Skobieranda F   +7 more
doaj   +1 more source

Hyperactivity in Mice Induced by Opioid Agonists with Partial Intrinsic Efficacy and Biased Agonism Administered Alone and in Combination with Morphine

Biomolecules, 2023
Opioid analgesics such as morphine and fentanyl induce mu-opioid receptor (MOR)-mediated hyperactivity in mice. Herein, we show that morphine, fentanyl, SR-17018, and oliceridine have submaximal intrinsic efficacy in the mouse striatum using 35S-GTPγS ...
Agnes Acevedo-Canabal, Travis W. Grim, Cullen L. Schmid, Nina McFague, Edward L. Stahl, Nicole M. Kennedy, Thomas D. Bannister, Laura M. Bohn   +7 more
doaj   +2 more sources

Approval of oliceridine (TRV130) for intravenous use in moderate to severe pain in adults [PDF]

British Journal of Anaesthesia, 2020
EditordOpioids used for the treatment of moderate to severe pain in an appropriate setting with appropriate management (stewardship) have good efficacy. However, when these are used long term their efficacy is questionable. Tolerance develops leading to escalating doses and a vicious circle of side-effects.
David Lambert, Girolamo Calo'
openaire   +5 more sources

CHARMM Force-Field Parameters for Morphine, Heroin, and Oliceridine, and Conformational Dynamics of Opioid Drugs

Journal of Chemical Information and Modeling, 2021
Opioid drug binding to specialized G protein-coupled receptors (GPCRs) can lead to analgesia upon activation via downstream Gi protein signaling and to severe side effects via activation of the β-arrestin signaling pathway. Knowledge of how different opioid drugs interact with receptors is essential, as it can inform and guide the design of safer ...
Thomas Giannos, Samo Lesnik, Urban Bren, Milan Hodoscek, Tatiana Domratcheva, Ana-Nicoleta Bondar   +5 more
openaire   +5 more sources

Oliceridine and its potential to revolutionize GI endoscopy sedation

Saudi Journal of Anaesthesia, 2020
Providing sedation to patients undergoing gastrointestinal (GI) endoscopy is a controversial and emotive issue. The mainstay of sedation is propofol, whose administration is within the sole jurisdiction of anesthesia providers, at least in the USA. Attempts have been made to seize the authority by the GI community. One of the first attempts was the use
Goudra, Basavana, Singh, Preet Mohinder
openaire   +6 more sources

Comparison of hemodynamic responses to endotracheal intubation with oliceridine and sufentanil during induction: a randomized controlled trial [PDF]

BMC Anesthesiology
Background Oliceridine, a G-protein-biased μ-opioid receptor agonist, offers a potential alternative to conventional opioids by reducing adverse effects. However, its efficacy in attenuating the hemodynamic response to endotracheal intubation compared to
Yu Zhang, Yuanyuan Li, Lei Li, Yan Gao, Xin Zhang, Shengzhe Shi, Yujuan Zheng, Junhong Yang, Yaowu Bai   +8 more
doaj   +2 more sources

Effect of oliceridine on hypoxia during sedated hysteroscopy: a Phase 4 randomized clinical trial [PDF]

Communications Medicine
Background Hypoxia is a common complication in hysteroscopic surgery under sedation with conventional opioids. Oliceridine, a novel G protein-biased μ-opioid receptor agonist, provides effective analgesia with fewer opioid-related adverse events, but its
Ye Liu, Mingshu Tao, Biran Dai, Xia Yin, Xinyu Gu, Jie Xiao, Jun-Li Cao, Weifeng Yu, Liqun Yang, Song Zhang   +9 more
doaj   +2 more sources

The Influence of Renal or Hepatic Impairment on the Pharmacokinetics, Safety, and Tolerability of Oliceridine [PDF]

Clinical Pharmacology in Drug Development, 2019
AbstractOliceridine is a G protein–biased ligand at the μ‐opioid receptor in development for treatment of moderate to severe acute pain. A phase 1, open‐label, single‐dose study investigated the pharmacokinetics and safety of oliceridine 0.5 mg intravenous (IV) in subjects with end‐stage renal disease (ESRD, n = 9) versus 1 mg in healthy controls (n ...
Nafziger, Anne N., Arscott, Kelly A., Cochrane, Kristina, Skobieranda, Franck, Burt, David A., Fossler, Michael J.   +5 more
openaire   +3 more sources