Results 51 to 60 of about 699 (156)

Determine of 90% Effective Dose of Oliceridine Combined with Etomidate for Inhibiting Laryngeal Mask Airway Insertion Responses in Patients of Different Ages: A Biased-Coin Sequential Allocation Dose-Finding Trial [PDF]

Drug Design, Development and Therapy
Fangsheng Xu,1,* Yuanyuan Cui,2,* Zhengle Wang,1 Rongguang Liu,1 Jian Tang,1 Yuan Xu,1 Luoyun Li,3 Chunyu Li,4 Meifang Wang,1 Jianfeng Pu1 1Department of Anesthesiology, Changshu No.
Xu F, Cui Y, Wang Z, Liu R, Tang J, Xu Y, Li L, Li C, Wang M, Pu J   +9 more
doaj   +2 more sources

A Dive Into Oliceridine and Its Novel Mechanism of Action [PDF]

Cureus, 2021
The current state of the opioid epidemic has revealed the need of utilizing proper pain management, especially in the postoperative setting where there is overuse of potent analgesics. However, the adequate treatment of pain is necessary to reduce mortality and cost of burden while increasing recovery and improving quality of life.
Shah, Anjali, Shah, Reema, Fahim, Germin, Brust-Sisti, Lindsay A   +3 more
openaire   +2 more sources

Global Trends in Oliceridine (TRV130) Research from 2013 to 2024: A Bibliometrics and Knowledge Graph Analysis

Drug Design, Development and Therapy
Cong Wang,1 Lidan Liu,1 Xue Bai2 1Department of Anesthesiology, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, People’s Republic of China; 2Department of Health Management, Shengjing Hospital of China Medical University ...
Wang C, Liu L, Bai X
doaj   +3 more sources

Effective Doses of Oliceridine Combined with Propofol for Painless Hysteroscopy: A Prospective Dose-Finding Study

International Journal of General Medicine
Liangliang Gao,1,* Aiping Tan,1,* Zehui Wang,2 Lei Wei,1 Xingshuang Wang1 1Department of Anesthesiology, Suzhou Hospital Affiliated to Nanjing Medical University, Suzhou, People’s Republic of China; 2Department of Anesthesiology, Cixi ...
Gao L, Tan A, Wang Z, Wei L, Wang X
doaj   +3 more sources

Functional bias of morphine and oliceridine under conditions of minor injury [PDF]

Molecular Pain, 2021
Recent reports suggest pain from surgical injury may influence the risks associated with exposure to opioids. In mice, hind-paw incision attenuates morphine-primed reinstatement due to kappa opioid receptor activation by dynorphin. In this focused group of studies, we examined the hypotheses that kappa-opioid receptor activation in the nucleus ...
Chinwe Nwaneshiudu, Xiao-Yu Shi, Peyman Sahbaie, J David Clark   +3 more
openaire   +2 more sources

Oliceridine- Opioid of the 21st Century

Saudi Journal of Anaesthesia, 2022
Oliceridine (Olinvyk® Trevena, PA, USA) was approved by the United States Food and Drug Administration for clinical use on Aug 8, 2020. Even though, the indication of its approval is very restrictive (to manage moderate-to-severe acute pain in adults when the pain is severe enough), for such an innovative opioid, off-label indications are bound to ...
openaire   +3 more sources

Oliceridine — a unique drug among opioid analgesics

Journal of Medical Science, 2020
Oliceridine is an opioid with a different mechanism of action compared to classical opioid agonists, e.g. morphine, as it does not act through active metabolites and activates the β-arrestin pathway to a small extent, thereby reducing dangerous side effects and broadening the therapeutic window.
Ewa Gibuła-Tarłowska, Magdalena Burat, Ewa Kędzierska   +2 more
openaire   +4 more sources

A systematic review of opioid use and multimodal strategies in solid organ transplant recipients and living donors

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 43, Issue 6, Page 514-551, June 2023., 2023
Abstract The opioid epidemic has impacted analgesia in the postoperative period for solid organ transplant (SOT) donors and recipients. However, optimal pain management and opioid stewardship strategies have not been identified across this unique population.
Heather L. Kutzler, Alicia B. Lichvar, David Quan, Lyndsey J. Bowman, Adam Diamond, Christina Doligalski, Tina Griffin, Jennifer Melaragno, Helen Sweiss, James Fleming   +9 more
wiley   +1 more source

Oral Oxycodone‐Induced Respiratory Depression During Normocapnia and Hypercapnia: A Pharmacokinetic‐Pharmacodynamic Modeling Study

Clinical Pharmacology &Therapeutics, Volume 113, Issue 5, Page 1080-1088, May 2023., 2023
The widely prescribed opioid oxycodone may cause lethal respiratory depression. We compared the effects of oxycodone on breathing and antinociception in healthy young volunteers. After pharmacokinetic/pharmacodynamic (PK/PD) modeling, we constructed utility functions to combine the wanted and unwanted end points into a single function.
Marieke Hellinga, Marijke Hyke Algera, Erik Olofsen, Rutger van der Schrier, Elise Sarton, Monique van Velzen, Albert Dahan, Marieke Niesters   +7 more
wiley   +1 more source

Supplementary materials: Cost–effectiveness and cost–benefit analysis of oliceridine in the treatment of acute pain

, 2021
These are peer-reviewed supplementary tables for the article 'Cost–effectiveness and cost-benefit analysis of oliceridine in the treatment of acute pain' published in the Journal of Comparative Effectiveness Research.Supplementary Table 1. Estimated mean
Linda Wase (9569954), Kit N. Simpson (10760663), Mark A. Demitrack (9569957), Michael J. Fossler (6945680)   +3 more
core   +1 more source