Results 91 to 100 of about 699 (156)

Global Trends and Insights Into Opioid Utilization for Postoperative Pain Management: A Bibliometric Analysis (2014–2024)

Pain Research and Management, Volume 2025, Issue 1, 2025.
Background: Opioids are a class of potent analgesics extensively utilized for the management of moderate to severe pain. They are integral to postoperative analgesia, effectively mitigating pain following surgical interventions. The present study aims to undertake a comprehensive bibliometric analysis to evaluate research trends and focal areas within ...
Lingxian Kong, Jiangang Hu, Massimiliano Valeriani   +2 more
wiley   +1 more source

Biased agonism of clinically approved μ-opioid receptor agonists and TRV130 is not controlled by binding and signaling kinetics

, 2020
Binding and signaling kinetics have previously proven important in validation of biased agonism at GPCRs. Here we provide a comprehensive kinetic pharmacological comparison of clinically relevant μ-opioid receptor agonists, including the novel biased ...
Pedersen, Daniel Sejer, Bouvier, Michel, Møller, Thor Christian, Bräuner-Osborne, Hans, Wrobel, Tomasz Marcin, Pedersen, Henrik, Pedersen, Mie Fabricius, Gabriele, Federica, Matosiuk, Dariusz, Foster, Simon Richard, Märcher-Rørsted, Emil   +10 more
core   +1 more source

Oliceridine. mu-Opioid receptor ligand, Treatment of moderate to severe acute pain

Drugs of the Future, 2016
Cole, P.
openaire   +2 more sources

Efficacy, safety, and side effects of oliceridine in acute postoperative pain, a protocol for a systematic review and meta-analysis.

This will be the first meta-analysis on the efficacy, safety, and side effects of oliceridine on postoperative pain. Our aim with this work is to evaluate the clinical utility of this relatively new substance in a broad postoperative context. Oliceridine
Alexander Wolf, Andrea Witowski, Michael Adamzik, Matthias Unterberg, Anne Wolf   +4 more
core   +2 more sources

A tetrapeptide class of biased analgesics from an Australian fungus targets the µ-opioid receptor [PDF]

, 2019
An Australian estuarine isolate ofPenicilliumsp. MST-MF667 yielded3 tetrapeptides named the bilaids with an unusual alternating LDLDchirality. Given their resemblance to known short peptide opioidagonists, we elucidated that they were weak (Kilow ...
Dekan, Zoltan, Christie, Macdonald, Alewood, Paul F., Stewart, Michael, Kelly, Eamonn P, Fontaine, Frank, Piggott, Andrew, Sianati, Setareh, Mohammadi, Sarasa, Du, Yan, Christie, MacDonald J., Sutcliffe, Katy J., Alewood, Paul, Lacey, Ernest, Singh, Paramijt, Sessions, Richard, Mallet, Christopher, Kelly, Eamonn ., Sutcliffe, Katy, Kelly, Eamonn, Sessions, Richard B, Wang, Anna M., Lacey, Earnest, Ratnayake, Ranjala, Jin, Aihua H., Wang, Anna, Jin, Aihua, Jin, Aihue, Mallet, Christian, Canals, Meritxell, Singh, Paramjit, Du, Yan P., Yousuf, Arsalan, Sessions, Richard B., Mohammadi, Sarasa A., Piggott, Andrew M., Mallet, Christophe, Gillis, Alexander, Christie, Macdonald J, Capon, Robert, Capon, Robert J.   +40 more
core   +1 more source

Estimation of ED50 and ED95 of Oliceridine Required to Suppress the Bronchoscopy Response in Patients Undergoing Fiberoptic Bronchoscopy Under Sedation with Cipepofol: An Up-and-Down Sequential Allocation Trial

Drug Design, Development and Therapy
Dongxue Wu,1,* Yeqing Liao,1,* Yanlin Qin,1,* Yafeng Wang,2 Bing Xu,3 Qiuling Chen,1 Xianting Wang,1 Xiaoshan Wu,1 Yalan Li,2 Xuehai Guan1 1Department of Anesthesiology, the First Affiliated Hospital of Guangxi Medical University,
Wu D, Liao Y, Qin Y, Wang Y, Xu B, Chen Q, Wang X, Wu X, Li Y, Guan X   +9 more
doaj  

The ED90 of Oliceridine for Tracheal Intubation in Children: A Biased-Coin Up-and-Down Parallel Dose-Finding Study

Drug Design, Development and Therapy
Liqun Cheng,1,2 Jing Jiang,1– 3 Mengqi Li,1,2 Yingzhi Dan,1,2 Jijian Zheng,1,2 Yue Huang,1– 3 Kan Zhang1– 3 1Department of Anesthesiology, Shanghai Children’s Medical Center Affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai ...
Cheng L, Jiang J, Li M, Dan Y, Zheng J, Huang Y, Zhang K   +6 more
doaj  

Estimation of ED50 and ED95 of oliceridine required to suppress bronchoscopic responses during remimazolam sedation: study protocol for an up-and-down sequential allocation trial

BMJ Open
Background Flexible bronchoscopy frequently provokes airway reflexes that impair patient comfort and procedural quality. Remimazolam provides effective sedation but often requires adjunctive opioids to suppress coughing and movement.
Ke Jiang, Anhong Li, Yuancheng Zhou, Xueying Zhou, Bailong Hu   +4 more
doaj   +1 more source

Oliceridine: Progress in Clinical Research on a New Analgesic Drug

Asploro Journal of Biomedical and Clinical Case Reports
Oliceridine is a new class of μ-opioid receptor agonists, which is relatively selective to μ-opioid receptors and exerts analgesic effects by interacting with μ-opioid receptors (MORS). Compared with morphine, it has the characteristics of fast onset, strong analgesic effect, low incidence of respiratory depression and gastrointestinal adverse ...
openaire   +2 more sources

A comprehensive review of partial opioid agonists for the treatment of chronic pain

, 2020
Chronic pain is a common condition that is being increasingly recognized, diagnosed, and treated in a variety of settings. Opioids can be used to treat chronic pain but at the cost of adverse effects and risk of dependence.
Jung J. W., Paladini A., Varrassi G., Urits I., Gress K., Kaye A. D., Charipova K., Viswanath O.   +7 more
core   +1 more source