Results 141 to 150 of about 97,181 (355)

Human Brain Cell‐Type‐Specific Aging Clocks Based on Single‐Nuclei Transcriptomics

open access: yesAdvanced Science, EarlyView.
Muralidharan and colleagues develop cell‐type‐specific transcriptomic aging clocks using single‐nucleus RNA sequencing of human post mortem prefrontal cortex samples. These clocks accurately predict age and identify distinct aging trajectories in specific brain cell types.
Chandramouli Muralidharan   +12 more
wiley   +1 more source

Adolescent binge ethanol impacts H3K9me3-occupancy at synaptic genes and the regulation of oligodendrocyte development

open access: yesFrontiers in Molecular Neuroscience
IntroductionBinge drinking in adolescence can disrupt myelination and cause brain structural changes that persist into adulthood. Alcohol consumption at a younger age increases the susceptibility of these changes.
Emily R. Brocato   +6 more
doaj   +1 more source

Effect of Glucose Deprivation on Sulfatide Synthesis and Oligodendrocytes in Cultured Brain Cells of Newborn Mice [PDF]

open access: bronze, 1981
K Zuppinger   +6 more
openalex   +1 more source

Neuro‐Cancer Interactions Shape Glioma Intratumoral Heterogeneity

open access: yesAdvanced Science, EarlyView.
This review proposes a conceptual framework for understanding glioma intratumoral heterogeneity shaped by neuro‐cancer interactions: functional patterns and transcriptional states. Functional patterns manifest as three major neural‐like adaptations with spatial and potentially hierarchical relationships, including neurogliomal synapses, glioma networks,
Tong Wu   +8 more
wiley   +1 more source

Mechanisms Governing Oligodendrocyte Viability in Multiple Sclerosis and Its Animal Models

open access: yesCells
Multiple sclerosis (MS) is a chronic autoimmune inflammatory demyelinating disease of the central nervous system (CNS), which is triggered by an autoimmune assault targeting oligodendrocytes and myelin.
Zhixin Lei, Wensheng Lin
doaj   +1 more source

Bioprinted Organoids: An Innovative Engine in Biomedicine

open access: yesAdvanced Science, EarlyView.
Bioprinted organoids refer to either the printing of stem cells into tissue shape and subsequent differentiate into organoids, or assembling induced organoids as bioinks to replicate native organ. It enables the creation of miniaturized organs with complex architectures and physiological functions, potentially enhancing reproducibility, throughput, and
Zhengwei Li   +11 more
wiley   +1 more source

Advanced Brain‐on‐a‐Chip for Wetware Computing: A Review

open access: yesAdvanced Science, EarlyView.
Exploring Low‐Power, Beyond‐Silicon‐Computing Bio‐Computing: Brain‐on‐a‐Chip Technology. This article reviews the applications of Brain‐on‐a‐Chip in Wetware Computing, including in vitro‐cultured brain organoids, microelectrode arrays, electrophysiological interfaces, and microfluidic platforms, as well as data processing methods. It also looks forward
Shangchen Li   +11 more
wiley   +1 more source

Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer’s disease model

open access: yesNature Neuroscience, 2019
Peisu Zhang   +10 more
semanticscholar   +1 more source

Home - About - Disclaimer - Privacy