Results 171 to 180 of about 118,814 (348)

Comparative Safety Profiles of Ocrelizumab and Rituximab in Multiple Sclerosis Treatment Using Real‐World Evidence

Annals of Neurology, EarlyView.
Objective The objective of this study was to compare the long‐term safety profiles of ocrelizumab and rituximab in persons with multiple sclerosis (MS). Methods Using retrospective data from the University of California (UC) Health System, we simulated a target clinical trial. The primary cohort from UC San Francisco (UCSF) and a validation cohort from
Gabriel Cerono, Bruce A.C. Cree, Stephen L. Hauser, Sergio E. Baranzini   +3 more
wiley   +1 more source

Amyloid‐β peptide enhances tumor necrosis factor‐α‐induced iNOS through neutral sphingomyelinase/ceramide pathway in oligodendrocytes [PDF]

, 2005
Chongyang Zeng, J. T. Lee, Hui Chen, Shuai Chen, Chung Y. Hsu, Jian Xu   +5 more
openalex   +1 more source

Epigenetic age acceleration is associated with oligodendrocyte proportions in MSA and control brain tissue

, 2022
Megha Murthy, Gemma Shireby, Yasuo Miki, Emmanuelle Viré, Tammaryn Lashley, Thomas T. Warner, Jonathan Mill, Conceição Bettencourt   +7 more
openalex   +1 more source

Resilience to Endoplasmic Reticulum Stress Mitigates Membrane Hyperexcitability Underlying Late Disease Onset in a Murine Model of SCA6

Annals of Neurology, EarlyView.
Objective An enduring puzzle in many inherited neurological disorders is the late onset of symptoms despite expression of function‐impairing mutant protein early in life. We examined the basis for onset of impairment in spinocerebellar ataxia type 6 (SCA6), a canonical late‐onset neurodegenerative ataxia which results from a polyglutamine expansion in ...
Haoran Huang, Taylor L. Charron, Min Fu, Miranda Dunn, Deborah M. Jones, Praveen Kumar, Satoshi Ishishita, Allan‐Hermann Pool, Ashwinikumar Kulkarni, Genevieve Konopka, Vikram G. Shakkottai   +10 more
wiley   +1 more source

Depletion of Microglia Increases Cortical Oligodendrocyte Density During Remyelination. [PDF]

Glia
Loo HK, Gallegos J, Mialki C, Perrin GE, Malloy T, Orthmann-Murphy JL.   +5 more
europepmc   +1 more source

Minocycline plus N-acteylcysteine induces remyelination, synergistically protects oligodendrocytes and modifies neuroinflammation in a rat model of mild traumatic brain injury [PDF]

, 2017
Margalit Haber, Jessica James, Justine Kim, Michael Sangobowale, Rachel Irizarry, Johnson Ho, Elena Nikulina, Natalia Grinkina, Albana Ramadani, Isabella Hartman, Peter J. Bergold   +10 more
openalex   +1 more source

Skeletal Muscle Biomarkers of Amyotrophic Lateral Sclerosis: A Large‐Scale, Multi‐Cohort Proteomic Study

Annals of Neurology, EarlyView.
Objective Biomarkers with clear contexts of use are important tools for amyotrophic lateral sclerosis (ALS) therapy development. Understanding their longitudinal trajectory in the untreated state is key to their use as potential markers of pharmacodynamic response.
Oleksandr Dergai, Joanne Wuu, Magdalena Koziczak‐Holbro, Andrea Malaspina, Volkan Granit, Jessica P. Hernandez, Anne Cooley, Ruchika Sachdev, Lili Yu, Michael Bidinosti, Ludivine Flotte, Mark Nash, Lori L. Jennings, James D. Berry, Lucie I. Bruijn, Sophie Brachat, Michael Benatar   +16 more
wiley   +1 more source

Editorial: Myelin in white mater function and related diseases

Frontiers in Molecular Neuroscience, 2023
Zhen Tian, An Cheng
doaj   +1 more source

Therapeutic targeting of oligodendrocytes in an agent-based model of multiple sclerosis. [PDF]

PLoS Comput Biol
Weatherley GR, Araujo RP, Dando SJ, Jenner AL.   +3 more
europepmc   +1 more source

Insulin‐like growth factor type 1 receptor signaling in the cells of oligodendrocyte lineage is required for normal in vivo oligodendrocyte development and myelination

, 2006
Martha Zeger, Greg Popken, Jihui Zhang, Shouhong Xuan, Qing Lu, Markus H. Schwab, Klaus‐Armin Nave, David H. Rowitch, A. Joseph D’Ercole, Ping Ye   +9 more
openalex   +2 more sources