Results 181 to 190 of about 97,181 (355)

Deficiency of nNOS in adult‐born dentate granule cells causes epilepsy

open access: yesEpilepsia Open, EarlyView.
Abstract Objective This study aimed to elucidate the molecular role of neuronal nitric oxide synthase (nNOS, encoded by Nos1) in adult‐born dentate granule cells (DGCs) during temporal lobe epilepsy (TLE). Methods We used GFP‐expressing retrovirus (RV) to analyze morphological changes in DGCs.
Hanyu Huang   +11 more
wiley   +1 more source

A Role in Migration for the αvβ1 Integrin Expressed on Oligodendrocyte Precursors [PDF]

open access: hybrid, 1996
R. Milner   +3 more
openalex   +1 more source

AAV‐Based Intracerebral Administration of BDNF Promotes Myelin Repair and Cognitive Improvement After Cuprizone‐Induced Demyelination

open access: yesGlia, EarlyView.
AAV‐BDNF improves cognitive performance after cuprizone‐induced de‐myelination. BDNF promotes OPC maturation and enhances remyelination in the corpus callosum. Mitochondrial integrity is preserved through reduced swelling and improved morphology. ABSTRACT Multiple sclerosis (MS) is a chronic neurological disorder involving immune‐mediated demyelination
Yousra El Ouaamari   +14 more
wiley   +1 more source

The role of oligodendroglial dysfunction in Huntington's disease. [PDF]

open access: yesJ Huntingtons Dis
Li X   +5 more
europepmc   +1 more source

Building Immunocompetent Cerebral Organoids From a Developmental Perspective

open access: yesGlia, EarlyView.
Conventional cerebral organoids do not contain microglia, which must be added. We propose recommendations to assess microglial immunocompetence using quantitative approaches and stringent statistical analysis to help develop standardized protocols. ABSTRACT Cerebral organoids derived from human induced pluripotent stem cells (iPSCs) are increasingly ...
Xabier Cuesta‐Puente   +8 more
wiley   +1 more source

Endoplasmic Reticulum Stress Amplifies Cytokine Responses in Astrocytes via a PERK/eIF2α/JAK1 Signaling Axis

open access: yesGlia, EarlyView.
ER stress amplifies TNF‐α, OSM, and IL‐1β responses in astrocytes. PERK and JAK1 signaling are required for the synergistic interaction between ER stress and inflammatory cytokines. Translational suppression attenuates the synthesis of the negative feedback regulators IκBα and SOCS3.
Anirudhya Lahiri   +8 more
wiley   +1 more source

Oligodendrocytes and myelination: pioneering new frontiers in cognitive neuroscience. [PDF]

open access: yesFront Neurosci
Zhang N   +9 more
europepmc   +1 more source

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