Results 261 to 270 of about 118,814 (348)

The Second Hit Hypothesis in Animal and Human Dystonia: The Role of Peripheral Nerve Trauma and Spinal Cord Injury

Movement Disorders, EarlyView.
The “second‐hit” hypothesis proposes that both a genetic predisposition and an environmental insult—such as peripheral nerve trauma or spinal cord injury—are required for dystonia development. This review explores how neuroinflammation and maladaptive plasticity, triggered by nerve and spinal cord injury, contribute to dystonia pathogenesis.
Lisa Harder‐Rauschenberger, Chi Wang Ip   +1 more
wiley   +1 more source

Nuclear Alpha‐Synuclein: Mechanisms and Implications for Synucleinopathies

Movement Disorders, EarlyView.
Abstract Alpha‐synuclein (aSyn), historically studied for its synaptic functions and central role in Lewy body pathology, is emerging as a protein with significant nuclear activities relevant to Parkinson's disease (PD) and related synucleinopathies. Recent advances reveal that aSyn dynamically localizes to neuronal nuclei in both health and disease ...
Tiago Fleming Outeiro, David J. Koss
wiley   +1 more source

Amino Acid Sensing Ability by the Mechanistic Target of Rapamycin in Oligodendrocytes

, 2020
Emma England
openalex   +1 more source

Specific amplifications and copy number decreases during human neural stem cells differentiation towards astrocytes, neurons and oligodendrocytes

, 2017
Ulrike Fischer, Ella Kim, Andreas Keller, Eckart Meese   +3 more
openalex   +2 more sources

Enhancing Selective Brain Cancer Therapy: Integrating Nanomedicine and Molecular Dynamics to Target the Cancerous Lipid Composition

Nano Select, EarlyView.
Improving selectivity within therapeutic design is critical to ensure targeted delivery to brain tumors. Targeting the cellular membrane composition distinctive of the blood–brain barrier and brain cancer cells is explored in this review. Nanomedicine can be utilized for precise tumor recognition, and detailed mechanistic interactions of therapeutics ...
Mahnoor Kadri, Dominique de Jong‐Hoogland, Martin B. Ulmschneider   +2 more
wiley   +1 more source

White Matter in Crisis: Oligodendrocytes and the Pathophysiology of Multiple Sclerosis. [PDF]

Cells
García-Domínguez M.
europepmc   +1 more source

Enhancing Neural Stem Cell Proliferation Using Polyurethane/CNT Scaffolds Functionalized With Liposomal Hesperidin for Neural Tissue Engineering

Nano Select, EarlyView.
A multifunctional electrospun scaffold combining polyurethane, carbon nanotubes, and liposomal hesperidin supports neural stem cell survival, adhesion, and expansion. This platform enhances conductivity, mechanical strength, and hydrophilicity while mimicking the native neural environment.
Arman Abroumand Gholami, Amir Mahdi Molavi, Meshkat Omrannezhad, Tahere Mokhtari, Shokoufeh Rahmani, Payam Moharreri, Fatemeh Gheybi, Fatemeh Tahmasebi, Hamideh Babaloo   +8 more
wiley   +1 more source

Spironolactone Targets Retinoid X Receptor γ to Promote Myelin Sheath Regeneration. [PDF]

Neurol Neuroimmunol Neuroinflamm
Sun QQ, Ai RS, Chai NN, Han B, Bao MY, Li YB, Ma GX, Wang LJ, Qian ZQ, Li X, Zhang Y.   +10 more
europepmc   +1 more source

The Sooner, the Better: Neuroprotective Strategies in Fetuses With Congenital Heart Disease

Prenatal Diagnosis, EarlyView.
ABSTRACT Congenital heart disease (CHD) is the most frequent congenital malformation at birth and is associated with neurodevelopmental impairments. Alterations in cardiovascular physiology can lead to reduced cerebral blood perfusion and oxygenation, which negatively affects brain growth and maturation.
Maaike Nijman, Mirthe E. M. van der Meijden, Johannes M. P. J. Breur, Raymond Stegeman, Nicolaas J. G. Jansen, Mireille N. Bekker, Manon J. N. L. Benders, Nathalie H. P. Claessens   +7 more
wiley   +1 more source

Oligodendroglial Densities and Myelin Structure Are Altered in TDP-43 Related Amyotrophic Lateral Sclerosis. [PDF]

Glia
Lewis KN, Craig GA, Mason J, Tomas D, Cuic B, Walker AK, Gonsalvez DG, Turner BJ, Barton SK.   +8 more
europepmc   +1 more source