Results 21 to 30 of about 85,792 (299)

Oligodendrocytes in Schizophrenia [PDF]

Schizophrenia Research and Treatment, 2011
Despite the many neuroimaging studies that suggest gray matter volume reductions in schizophrenia, there is no compelling postmortem evidence to suggest neuronal loss, nor is there a distinctive or specific signature of gray matter abnormalities in schizophrenia.
Xu, Haiyun, Haroutunian, Vahram, Bartzokis, George, Shenton, Martha E.   +3 more
openaire   +2 more sources

Oligodendrocyte-derived IL-33 promotes survival to neurotropic flavivirus infection.

, 2023
(A) Ratios of IL-33+ cells in indicated brain regions in adult B6/J mice with HBSS injection. (B) Representative immunofluorescent images of IL-33+ cell loss in B6/J Hippocampal CA3 7 days post intracranial infection with WNV-E218A (20x magnification ...
Steven F. Ziegler (14902049), Andrew Oberst (686925), Joshua M. Ames (17419969), Geoffrey T. Norris (17419966)   +3 more
core   +1 more source

Demyelination and oligodendrocytes

Rinsho Shinkeigaku, 2011
Although neurological sequelae are attributable to poor regeneration of the central nervous system, oligodendrocytes demonstrate robust regenerative response even in adults. Accumulating evidence indicates that the glial cells identified by surface expression of the proteoglycan NG2 are the cellular source of newly-developed oligodendrocytes following ...
Itoh, Takayuki, Horiuchi, Makoto, Wakayama, Kouji, Itoh, Aki, Pleasure, David   +4 more
openaire   +3 more sources

Glycoproteins as targets of autoantibodies in CNS inflammation: MOG and more [PDF]

, 2012
B cells and antibodies constitute an important element in different inflammatory diseases of the central nervous system (CNS). Autoantibodies can serve as a biomarker to identify disease subgroups and may in addition contribute to the pathogenic process.
Mayer, Marie Cathrin, Meinl, Edgar, Marie Cathrin Mayer, Edgar Meinl, Meinl, E., Mayer, M.   +5 more
core   +1 more source

Adult mesenchymal stem cell therapy for myelin repair in Multiple Sclerosis [PDF]

, 2012
Multiple sclerosis (MS) is a demyelinating immune-mediated disease of the central nervous system (CNS). It is the most frequent neurological disease in young adults and affects over 2 million people worldwide.
Aigner, Ludwig, Ludwig Aigner, Francisco J Rivera, Rivera, Francisco J   +3 more
core   +1 more source

Network-Based Genomic Analysis of Human Oligodendrocyte Progenitor Differentiation

Stem Cell Reports, 2017
Summary: Impaired human oligodendrocyte progenitor cell (hOPC) differentiation likely contributes to failed remyelination in multiple sclerosis. The characterization of molecular pathways that regulate hOPC differentiation will provide means to induce ...
Suyog U. Pol, Jessie J. Polanco, Richard A. Seidman, Melanie A. O'Bara, Hani J. Shayya, Karen C. Dietz, Fraser J. Sim   +6 more
doaj   +1 more source

PBAF Subunit Pbrm1 Selectively Influences the Transition from Progenitors to Pre-Myelinating Cells during Oligodendrocyte Development

Cells, 2023
Oligodendrocyte development is accompanied by defined changes in the state of chromatin that are brought about by chromatin remodeling complexes. Many such remodeling complexes exist, but only a few have been studied for their impact on oligodendrocytes ...
Vanessa Waldhauser, Tina Baroti, Franziska Fröb, Michael Wegner   +3 more
doaj   +1 more source

Time-lapse imaging of the dynamics of CNS glial-axonal interactions in vitro and ex vivo [PDF]

, 2012
<b>Background</b> Myelination is an exquisite and dynamic example of heterologous cell-cell interaction, which consists of the concentric wrapping of multiple layers of oligodendrocyte membrane around neuronal axons.
Strachan, D., Susan C Barnett, Edgar Julia M., David Strachan (186501), Ioannidou, K., Julia M Edgar, Kurt I Anderson, Susan C. Barnett (186504), David Strachan, Julia M. Edgar (37537), Anderson, K.I., Barnett, S.C., Strachan David, Kalliopi Ioannidou, Kurt I. Anderson (186499), Edgar, J.M., Kalliopi Ioannidou (186497), Ioannidou Kalliopi, Anderson Kurt I., Barnett Susan C.   +19 more
core   +1 more source

OLIG2 regulates lncRNAs and its own expression during oligodendrocyte lineage formation

BMC Biology, 2021
Background Oligodendrocytes, responsible for axon ensheathment, are critical for central nervous system (CNS) development, function, and diseases. OLIG2 is an important transcription factor (TF) that acts during oligodendrocyte development and performs ...
Haichao Wei, Xiaomin Dong, Yanan You, Bo Hai, Raquel Cuevas-Diaz Duran, Xizi Wu, Natasha Kharas, Jia Qian Wu   +7 more
doaj   +1 more source

SOX4 inhibits oligodendrocyte differentiation of embryonic neural stem cells in vitro by inducing Hes5 expression

Stem Cell Research, 2018
SOX4 has been shown to promote neuronal differentiation both in the adult and embryonic neural progenitors. Ectopic SOX4 expression has also been shown to inhibit oligodendrocyte differentiation in mice, however the underlying molecular mechanisms remain
Luca Braccioli, Stephin J. Vervoort, Gianmarco Puma, Cora H. Nijboer, Paul J. Coffer   +4 more
doaj   +1 more source