Results 21 to 30 of about 88,065 (299)

Myelin basic protein peptide 45–89 induces the release of nitric oxide from microglial cells. [PDF]

, 2002
Continuous (24 h) exposure of mixed oligodendrocyte/microglial cells to peptides 45–89 derived from citrullinated C8 isoforms of myelin basic protein (MBP) induces cell death.
Pichkhadze, B., Machaidze, G., Mikeladze, D., Shanshiashvili, L., Ramsden, Jeremy J.   +4 more
core   +4 more sources

Demyelination and oligodendrocytes

Rinsho Shinkeigaku, 2011
Although neurological sequelae are attributable to poor regeneration of the central nervous system, oligodendrocytes demonstrate robust regenerative response even in adults. Accumulating evidence indicates that the glial cells identified by surface expression of the proteoglycan NG2 are the cellular source of newly-developed oligodendrocytes following ...
Itoh, Takayuki, Horiuchi, Makoto, Wakayama, Kouji, Itoh, Aki, Pleasure, David   +4 more
openaire   +3 more sources

Oligodendrocyte-derived IL-33 promotes survival to neurotropic flavivirus infection.

, 2023
(A) Ratios of IL-33+ cells in indicated brain regions in adult B6/J mice with HBSS injection. (B) Representative immunofluorescent images of IL-33+ cell loss in B6/J Hippocampal CA3 7 days post intracranial infection with WNV-E218A (20x magnification ...
Steven F. Ziegler (14902049), Andrew Oberst (686925), Joshua M. Ames (17419969), Geoffrey T. Norris (17419966)   +3 more
core   +1 more source

Glycoproteins as targets of autoantibodies in CNS inflammation: MOG and more [PDF]

, 2012
B cells and antibodies constitute an important element in different inflammatory diseases of the central nervous system (CNS). Autoantibodies can serve as a biomarker to identify disease subgroups and may in addition contribute to the pathogenic process.
Mayer, Marie Cathrin, Meinl, Edgar, Marie Cathrin Mayer, Edgar Meinl, Meinl, E., Mayer, M.   +5 more
core   +1 more source

Region Specific miRNA-mRNA Networks in Gray and White Matter Lesions of Progressive Multiple Sclerosis. [PDF]

Ann Clin Transl Neurol
ABSTRACT Objective Multiple sclerosis (MS) is a neurodegenerative demyelinating disease of the central nervous system. This study aimed to identify micro‐RNA (miRNA)–mRNA regulatory networks underlying region‐specific molecular mechanisms in white matter and gray matter lesions in progressive MS.
Sapra A, Rai NK, Niepokny TD, Courtney H, Tripathi A, Dutta R.   +5 more
europepmc   +2 more sources

Time-lapse imaging of the dynamics of CNS glial-axonal interactions in vitro and ex vivo [PDF]

, 2012
<b>Background</b> Myelination is an exquisite and dynamic example of heterologous cell-cell interaction, which consists of the concentric wrapping of multiple layers of oligodendrocyte membrane around neuronal axons.
Strachan, D., Susan C Barnett, Edgar Julia M., David Strachan (186501), Ioannidou, K., Julia M Edgar, Kurt I Anderson, Susan C. Barnett (186504), David Strachan, Julia M. Edgar (37537), Anderson, K.I., Barnett, S.C., Strachan David, Kalliopi Ioannidou, Kurt I. Anderson (186499), Edgar, J.M., Kalliopi Ioannidou (186497), Ioannidou Kalliopi, Anderson Kurt I., Barnett Susan C.   +19 more
core   +1 more source

PBAF Subunit Pbrm1 Selectively Influences the Transition from Progenitors to Pre-Myelinating Cells during Oligodendrocyte Development

Cells, 2023
Oligodendrocyte development is accompanied by defined changes in the state of chromatin that are brought about by chromatin remodeling complexes. Many such remodeling complexes exist, but only a few have been studied for their impact on oligodendrocytes ...
Vanessa Waldhauser, Tina Baroti, Franziska Fröb, Michael Wegner   +3 more
doaj   +1 more source

Adult mesenchymal stem cell therapy for myelin repair in Multiple Sclerosis [PDF]

, 2012
Multiple sclerosis (MS) is a demyelinating immune-mediated disease of the central nervous system (CNS). It is the most frequent neurological disease in young adults and affects over 2 million people worldwide.
Aigner, Ludwig, Ludwig Aigner, Francisco J Rivera, Rivera, Francisco J   +3 more
core   +1 more source

OLIG2 regulates lncRNAs and its own expression during oligodendrocyte lineage formation

BMC Biology, 2021
Background Oligodendrocytes, responsible for axon ensheathment, are critical for central nervous system (CNS) development, function, and diseases. OLIG2 is an important transcription factor (TF) that acts during oligodendrocyte development and performs ...
Haichao Wei, Xiaomin Dong, Yanan You, Bo Hai, Raquel Cuevas-Diaz Duran, Xizi Wu, Natasha Kharas, Jia Qian Wu   +7 more
doaj   +1 more source

Mechanical plasticity during oligodendrocyte differentiation and myelination [PDF]

, 2017
In the central nervous system, oligodendrocyte precursor cells are exclusive in their potential to differentiate into myelinating oligodendrocytes. Oligodendrocyte precursor cells migrate within the parenchyma and extend cell membrane protrusions that ...
Rubinstein, Boris, Andrea Cruz, Pinto, Inês Mendes, Jonah R. Chan, Relvas, João B, Helena S. Domingues, Boris Rubinstein, Inês Mendes Pinto, Cruz, Andrea, Domingues, Helena S, Chan, Jonah R, João B. Relvas   +11 more
core   +1 more source