Results 31 to 40 of about 85,792 (299)

Optogenetic control of cell differentiation in channelrhodopsin-2-expressing OS3, a bipotential glial progenitor cell line [PDF]

, 2017
Alterations in the intracellular ion environment have been identified as one of the signals playing a critical role in the control of cellular proliferation and differentiation; however, the mechanisms responsible for signal transduction remain unclear ...
Yamamoto, Ryusei, Suzuki, Hiromi, Sahashi, Hideki, Takido, Yuhei, Sawada, Makoto, Ono, Kenji   +5 more
core   +1 more source

FAS-dependent cell death in α-synuclein transgenic oligodendrocyte models of multiple system atrophy [PDF]

, 2013
Multiple system atrophy is a parkinsonian neurodegenerative disorder. It is cytopathologically characterized by accumulation of the protein p25α in cell bodies of oligodendrocytes followed by accumulation of aggregated α-synuclein in so-called glial ...
Christine L Kragh, Lubetzki Catherine, Kragh, Christine L, Manuela Neumann, Neumann, Manuela, Lubetzki, Catherine, Bernard Zalc, Glenda M Halliday, Jensen, Poul H, Gai, Wei-Ping, Wei-Ping Gai, Kragh, Christine, Zalc Bernard, Jensen, Poul, Christian Haass, Fillon, Gwenaëlle, Gysbers Amanda, Philipp J Kahle, Richter-Landsberg, Christiane, Fillon Gwenaëlle, Halliday, Glenda M., Hansen, Hanne D, Gwenaëlle Fillon, Gai, Wei Ping, Kragh, Christine L., Hansen, Hanne, Amanda Gysbers, Catherine Lubetzki, Smith, Wanli, Christiane Richter-Landsberg, Kahle Philipp J., Zalc, Bernard, Haass Christian, Richter-Landsberg, Christian, Halliday, Glenda,, Kahle, Philipp J., Kahle, Philipp, Gysbers, Amanda, Hansen, Hanne D., Jensen, Poul H., Richter-Landsberg Christiane, Halliday Glenda M., Kahle, Philipp J, Halliday, Glenda M, Kragh Christine L., Jensen Poul H., Neumann Manuela, Hansen Hanne D., Poul H Jensen, Haass, Christian, Hanne D Hansen, Gai Wei-Ping, Halliday, Glenda, M.   +52 more
core   +2 more sources

Sox17 Promotes Oligodendrocyte Regeneration by Dual Modulation of Hedgehog and Wnt Signaling

iScience, 2020
Summary: Signaling pathways that promote oligodendrocyte development improve oligodendrocyte regeneration and myelin recovery from demyelinating pathologies.
Xiaotian Ming, Jeffrey L. Dupree, Vittorio Gallo, Li-Jin Chew   +3 more
doaj   +1 more source

In vivo conversion of astrocytes into oligodendrocyte lineage cells with transcription factor Sox10; Promise for myelin repair in multiple sclerosis. [PDF]

PLoS ONE, 2018
Recent studies demonstrate that astroglial cells can be directly converted into functional neurons or oligodendrocytes. Here, we report that a single transcription factor Sox10 could reprogram astrocytes into oligodendrocyte-like cells, in vivo.
Akram Mokhtarzadeh Khanghahi, Leila Satarian, Wenbin Deng, Hossein Baharvand, Mohammad Javan   +4 more
doaj   +1 more source

Circulating transforming growth factor-β1 facilitates remyelination in the adult central nervous system

eLife, 2019
Oligodendrocyte maturation is necessary for functional regeneration in the CNS; however, the mechanisms by which the systemic environment regulates oligodendrocyte maturation is unclear. We found that Transforming growth factor (TGF)-β1, which is present
Machika Hamaguchi, Rieko Muramatsu, Harutoshi Fujimura, Hideki Mochizuki, Hirotoshi Kataoka, Toshihide Yamashita   +5 more
doaj   +1 more source

Neuroprotection in a Novel Mouse Model of Multiple Sclerosis [PDF]

, 2013
Multiple sclerosis is an immune-mediated, demyelinating and neurodegenerative disease that currently lacks any neuroprotective treatments. Innovative neuroprotective trial designs are required to hasten the translational process of drug development.
Coffey, P, Baker, MD, Coffey Pete, Jackson, SJ, Gavin Giovannoni, Baker David, Samuel J. Jackson (468645), Zubair Ahmed (9352), Jackson Samuel J., Zubair Ahmed, Ahmed, Z, Mark D Baker, Pete Coffey (422262), David Baker, Samuel J Jackson, Gavin Giovannoni (125820), Giovannoni Gavin, Munro Peter, Ahmed Zubair, Pete Coffey, David Baker (11642), Peter Munro (479715), Peter Munro, Lidster Katie, Baker Mark D., Baker, D, Lidster, K, Mark D. Baker (146531), Katie Lidster, Munro, P, Katie Lidster (479714), Giovannoni, G   +31 more
core   +1 more source

mTOR: A Link from the Extracellular Milieu to Transcriptional Regulation of Oligodendrocyte Development

ASN Neuro, 2013
Oligodendrocyte development is controlled by numerous extracellular signals that regulate a series of transcription factors that promote the differentiation of oligodendrocyte progenitor cells to myelinating cells in the central nervous system.
Teresa L. Wood, Kathryn K. Bercury, Stacey E. Cifelli, Lauren E. Mursch, Jungsoo Min, Jinxiang Dai, Wendy B. Macklin   +6 more
doaj   +1 more source

Folate Metabolism Regulates Oligodendrocyte Survival and Differentiation by Modulating AMPKα Activity

Scientific Reports, 2017
Folate, an essential micronutrient, is a critical cofactor in one-carbon metabolism for many cellular pathways including DNA synthesis, metabolism and maintenance.
Qinjie Weng, Jiajia Wang, Jiaying Wang, Biqin Tan, Jing Wang, Haibo Wang, Tao Zheng, Q. Richard Lu, Bo Yang, Qiaojun He   +9 more
doaj   +1 more source

Chemical Screening Identifies Enhancers of Mutant Oligodendrocyte Survival and Unmasks a Distinct Pathological Phase in Pelizaeus-Merzbacher Disease

Stem Cell Reports, 2018
Summary: Pelizaeus-Merzbacher disease (PMD) is a fatal X-linked disorder caused by loss of myelinating oligodendrocytes and consequent hypomyelination. The underlying cellular and molecular dysfunctions are not fully defined, but therapeutic enhancement ...
Matthew S. Elitt, H. Elizabeth Shick, Mayur Madhavan, Kevin C. Allan, Benjamin L.L. Clayton, Chen Weng, Tyler E. Miller, Daniel C. Factor, Lilianne Barbar, Baraa S. Nawash, Zachary S. Nevin, Angela M. Lager, Yan Li, Fulai Jin, Drew J. Adams, Paul J. Tesar   +15 more
doaj   +1 more source

Mature and Myelinating Oligodendrocytes Are Specifically Vulnerable to Mild Fluid Percussion Injury in Mice

Neurotrauma Reports, 2023
Myelin loss and oligodendrocyte death are well documented in patients with traumatic brain injury (TBI), as well as in experimental animal models after moderate-to-severe TBI.
Alexandra A. Adams, Teresa L. Wood, Haesun A. Kim   +2 more
doaj   +1 more source