Results 51 to 60 of about 88,065 (299)

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U‐87 MG cells

FEBS Open Bio, EarlyView.
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta, Sebastian GB Furness, Tahereh Gharbi, Ric De Paoli‐Iseppi, Shweta S. Joshi, Michael Clark, David L. Hare, Peter Wookey   +7 more
wiley   +1 more source

Understanding Further the Phenotypic Spectrum of Central Nervous System Inflammatory Demyelinating Disorders Using Unsupervised Clustering

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Central nervous system (CNS) inflammatory demyelinating syndromes, including multiple sclerosis (MS), aquaporin‐4 antibody–positive neuromyelitis optica spectrum disorder (AQP4 + NMOSD), and myelin oligodendrocyte glycoprotein (MOG) antibody–associated disease (MOGAD), occasionally overlap.
Bade Gulec, Elif Everest, Melih Tutuncu, Ugur Bilge, Sabahattin Saip, Ugur Uygunoglu, Aksel Siva   +6 more
wiley   +1 more source

Signalling through AMPA receptors on oligodendrocyte precursors promotes myelination by enhancing oligodendrocyte survival [PDF]

, 2017
Myelin, made by oligodendrocytes, is essential for rapid information transfer in the central nervous system. Oligodendrocyte precursors (OPs) receive glutamatergic synaptic input from axons but how this affects their development is unclear. Murine OPs in
Eleni Kougioumtzidou, William D Richardson, Attwell, D., Richardson, WD, Takahiro Shimizu, Sprengel, Rolf, Tohyama, K., Sprengel, R, David Attwell, Koujiro Tohyama, Shimizu, T, Nicola B Hamilton, Attwell, D, Kougioumtzidou, E., Hamilton, NB, Richardson, W., Shimizu, Takahiro, Kougioumtzidou, E, Attwell, David, Monyer, H., Richardson, William D., Hamilton, N., Tohyama, Koujiro, Monyer, Hannah, Rolf Sprengel, Shimizu, T., Tohyama, K, Monyer, H, Hannah Monyer, Hamilton, Nicola B.; id_orcid, Sprengel, R., Kougioumtzidou, Eleni   +31 more
core   +2 more sources

Oligodendrocyte progenitors: adult stem cells of the central nervous system

, 2014
Oligodendrocyte progenitors (OPs) are a major proliferating cell population within the adult CNS. In response to myelin loss or increasing demand, OPs have the capacity to differentiate into mature, myelinating oligodendrocytes. The name ‘oligodendrocyte
Richardson, W D, Franklin, R J, Tripathi, R B, Crawford, A H, Stockley, J H   +4 more
core   +1 more source

Ofatumumab in Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease: A Comparison With Rituximab

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the efficacy and safety of ofatumumab in patients with myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), and compare it with rituximab. Methods We conducted a single–center, observational study including 22 MOGAD patients treated with ofatumumab and 21 treated with rituximab.
Yuxin Fan, Lei Zhou, Jingzi ZhangBao, Hongmei Tan, Zhouzhou Wang, Chao Quan   +5 more
wiley   +1 more source

pH Microdomains in Oligodendrocytes [PDF]

Journal of Biological Chemistry, 2004
Oligodendrocytes (OLs) are cells that produce myelin in the central nervous system. Here we use ratiometric pH indicator dye to analyze intracellular pH in OLs in culture. The results reveal alkaline microdomains, which predominate in the perikaryon and proximal dendrites, and acidic microdomains, which predominate in distal dendrites.
Hyun-ah, Ro, John H, Carson
openaire   +2 more sources

TRAF4 expression in WT oligodendrocyte primary cultures.

, 2013
(A): Oligodendrocyte primary culture and differentiation: schemes of the morphological characteristics of the 4 stages of differentiation obtained: early OPC, late OPC, pre-myelinating and myelinating oligodendrocytes (numbered from 1 to 4); (B–H ...
Martine Muckenstrum (332589), Marie-Pierre Chenard (269908), Adrien Rousseau (332587), Frederic Gambino (5652514), Fabien Alpy (269903), Nadia Messadeq (332588), Catherine Tomasetto (269910), Yann Humeau (186719), Marie Kneib (332586), Marie-Christine Rio (269912), Sébastien Blaise (332585)   +10 more
core   +1 more source

MOGAD Is the Most Common Cause of Isolated Optic Neuritis in Children

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives The study aimed to characterize the clinical features, etiologies, and outcomes of isolated, first‐time pediatric ON in the post‐MOG‐IgG era. Methods This was a single‐center retrospective cohort study at Texas Children's Hospital of patients diagnosed with first‐time ON between 2018–2024, with follow‐up data collected through 2025.
Chaitanya Aduru, Akansha Chandrasekar, Kyla Blasingame, Jonathan Rosen, Jesse M. Levine, Karla Salazar, Madhuri Chilakapati, Rod Foroozan, Victoria Hardwick, Jonathan M. Yarimi, Nikita Shukla, Timothy E. Lotze, Kristen S. Fisher, Alexander J. Sandweiss   +13 more
wiley   +1 more source

Cc2d1b Contributes to the Regulation of Developmental Myelination in the Central Nervous System

Frontiers in Molecular Neuroscience, 2022
BackgroundNumerous studies have indicated that myelination is the result of the interplay between extracellular signals and an intricate network of transcription factors.
Jenica Acheta, Jiayue Hong, Haley Jeanette, Simrandeep Brar, Anish Yalamanchili, M. Laura Feltri, M. Chiara Manzini, Sophie Belin, Yannick Poitelon   +8 more
doaj   +1 more source

A Low Repeat Length in Oligodendrocyte Chromatin

, 1985
: The behavior of oligodendrocyte chromatin after micrococcal nuclease digestion of nuclei was assayed in brains of rats of four different ages. During oligodendrocyte differentiation, a decreasing sensitivity of the chromatin to enzymatic attack was ...
DI LIEGRO, Italia, Giuseppe Salemi, Italia Di Liegro, Alessandro Cestelli, CESTELLI, Alessandro, SALEMI, Giuseppe   +5 more
core   +1 more source