Results 51 to 60 of about 85,792 (299)

Isolation of neural stem and oligodendrocyte progenitor cells from the brain of live rats [PDF]

, 2021
Summary Postnatal brain neural stem and progenitor cells (NSPCs) cluster in anatomically inaccessible stem cell niches, such as the subependymal zone (SEZ). Here, we describe a method for the isolation of NSPCs from live animals, which we term “milking.”
Paraskevi Kakouri, Ilias Kazanis, Freyja McClenahan, Sofia Oikonomou, Dimitrios Dimitrakopoulos, Rana-Tahir Rasool, Michaela Kourla, Christina Dimitriou, Robin JM. Franklin, Melina Patsonis, Christos Koutsakis, Asterios Arampatzis, Evangelia Andreopoulou, Danai-Kassandra Meri   +13 more
core   +1 more source

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U‐87 MG cells

FEBS Open Bio, EarlyView.
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta, Sebastian GB Furness, Tahereh Gharbi, Ric De Paoli‐Iseppi, Shweta S. Joshi, Michael Clark, David L. Hare, Peter Wookey   +7 more
wiley   +1 more source

Localisation of NG2 immunoreactive neuroglia cells in the rat locus coeruleus and their plasticity in response to stress [PDF]

, 2014
The locus coeruleus (LC) nucleus modulates adaptive behavioural responses to stress and dysregulation of LC neuronal activity is implicated in stress-induced mental illnesses.
Metzger, Friedrich, Friedrich Metzger, Metzger, F, Seifi, Mohsen, Mohsen eSeifi, Johannes J. van der Want, Corteen, Nicole L, Jerome D Swinny, van der Want, Johannes J, Corteen, Nicole L., Seifi, M, Swinny, Jerome D, Corteen, NL, Johannes Jacobus Van Der Want, Nicole L. Corteen, Swinny, Jerome D., Swinny, JD, van der Want, Johannes J., van der Want, Johannes, Nicole Louise Corteen, Mohsen Seifi, Jerome D. Swinny, Friedrich eMetzger   +22 more
core   +2 more sources

Understanding Further the Phenotypic Spectrum of Central Nervous System Inflammatory Demyelinating Disorders Using Unsupervised Clustering

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Central nervous system (CNS) inflammatory demyelinating syndromes, including multiple sclerosis (MS), aquaporin‐4 antibody–positive neuromyelitis optica spectrum disorder (AQP4 + NMOSD), and myelin oligodendrocyte glycoprotein (MOG) antibody–associated disease (MOGAD), occasionally overlap.
Bade Gulec, Elif Everest, Melih Tutuncu, Ugur Bilge, Sabahattin Saip, Ugur Uygunoglu, Aksel Siva   +6 more
wiley   +1 more source

Activin receptors regulate the oligodendrocyte lineage in health and disease [PDF]

, 2018
The most prevalent neurological disorders of myelin include perinatal brain injury leading to cerebral palsy in infants and multiple sclerosis in adults.
Soong, Daniel; id_orcid, Frances L. Evans, Marie E. Bechler, Rebecca K. Holloway, Miron, Veronique E, Dillenburg, Alessandra, Gloria H. Su, Graeme Ireland, Daniel Soong, Smith, Colin; id_orcid, Evans, Frances L, Swire, Matthew, Su, Gloria H, Dillenburg Scur, Alessandra, Ireland, Graeme, Yuen, Tracy J, Tracy J. Yuen, Bechler, Marie E, Alessandra Dillenburg, Holloway, Rebecca K, Claire L. Davies, Davies, Claire L, Matthew Swire, Colin Smith, Anna Williams, Becher, Julie-Clare, Julie-Clare Becher, Veronique E. Miron, Williams, Anna   +28 more
core   +1 more source

Ofatumumab in Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease: A Comparison With Rituximab

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the efficacy and safety of ofatumumab in patients with myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), and compare it with rituximab. Methods We conducted a single–center, observational study including 22 MOGAD patients treated with ofatumumab and 21 treated with rituximab.
Yuxin Fan, Lei Zhou, Jingzi ZhangBao, Hongmei Tan, Zhouzhou Wang, Chao Quan   +5 more
wiley   +1 more source

pH Microdomains in Oligodendrocytes [PDF]

Journal of Biological Chemistry, 2004
Oligodendrocytes (OLs) are cells that produce myelin in the central nervous system. Here we use ratiometric pH indicator dye to analyze intracellular pH in OLs in culture. The results reveal alkaline microdomains, which predominate in the perikaryon and proximal dendrites, and acidic microdomains, which predominate in distal dendrites.
Hyun-ah, Ro, John H, Carson
openaire   +2 more sources

Oligodendrocyte progenitor cells: the ever mitotic cells of the CNS

, 2016
Oligodendrocyte Progenitor Cells (OPCs) first appear at mid embryogenic stages during development of the mammalian CNS and a mitotically active population of them remains present even into late adulthood.
Neumann, B., Kazanis, I.
core   +1 more source

MOGAD Is the Most Common Cause of Isolated Optic Neuritis in Children

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives The study aimed to characterize the clinical features, etiologies, and outcomes of isolated, first‐time pediatric ON in the post‐MOG‐IgG era. Methods This was a single‐center retrospective cohort study at Texas Children's Hospital of patients diagnosed with first‐time ON between 2018–2024, with follow‐up data collected through 2025.
Chaitanya Aduru, Akansha Chandrasekar, Kyla Blasingame, Jonathan Rosen, Jesse M. Levine, Karla Salazar, Madhuri Chilakapati, Rod Foroozan, Victoria Hardwick, Jonathan M. Yarimi, Nikita Shukla, Timothy E. Lotze, Kristen S. Fisher, Alexander J. Sandweiss   +13 more
wiley   +1 more source

Cc2d1b Contributes to the Regulation of Developmental Myelination in the Central Nervous System

Frontiers in Molecular Neuroscience, 2022
BackgroundNumerous studies have indicated that myelination is the result of the interplay between extracellular signals and an intricate network of transcription factors.
Jenica Acheta, Jiayue Hong, Haley Jeanette, Simrandeep Brar, Anish Yalamanchili, M. Laura Feltri, M. Chiara Manzini, Sophie Belin, Yannick Poitelon   +8 more
doaj   +1 more source