Results 71 to 80 of about 88,065 (299)

Oligodendrocyte Regeneration and CNS Remyelination Require TACE/ADAM17

, 2015
The identification of the molecular network that supports oligodendrocyte (OL) regeneration under demyelinating conditions has been a primary goal for regenerative medicine in demyelinating disorders.
Aguirre, Adan, Klingener, Michael, Crawford, Howard, Palazuelos Diego, Javier, Raines, Elaine   +4 more
core   +1 more source

Investigation of Complement Activation and Cytokine Signatures in AQP4+ NMOSD, MOGAD, and MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Aquaporin‐4‐IgG seropositive neuromyelitis optica spectrum disorder (AQP4+ NMOSD), myelin oligodendrocyte glycoprotein antibody‐associated disease (MOGAD), and multiple sclerosis (MS) are pathophysiologically distinct neuroinflammatory disorders. Complement activation is a major mechanism of injury in AQP4+ NMOSD, whereas its role in
Angeliki G. Filippatou, Susana Dominguez‐Penuela, David Acero‐Garces, Georgios Gakis, Matthew D. Smith, Yasmin Resto, Maria Reyes‐Mantilla, Haiwen Chen, Isabella Hernandez, Yana Said, Andrea Salazar‐Camelo, Christina Huynh, Alessia Tassoni, Ted Yednock, Rick Artis, Yaisa Andrews‐Zwilling, Scott D. Newsome, Shiv Saidha, Pavan Bhargava, Ellen M. Mowry, Kathryn C. Fitzgerald, Peter A. Calabresi, Carlos A. Pardo, Elias S. Sotirchos   +23 more
wiley   +1 more source

A Scoping Review and Meta‐Analysis of Proportions of Central Nervous System Manifestations Reported in Patients with Sjögren's Disease

Arthritis Care &Research, EarlyView.
Objective The objective of this scoping review was to synthesize evidence on the proportion of individuals living with Sjögren's disease who experience central nervous system (CNS) manifestations. Methods We searched MEDLINE (via PubMed) and Embase from 1980 through January 29, 2026, and the ECRI Guidelines Trust from 2020 through January 29, 2026 ...
Arun Varadhachary, Ghaith Noaiseh, Julie Frantsve‐Hawley, Frederick B. Vivino, Jennifer A. McCombe, Shamik Bhattacharyya, E. Sherwood Brown, Andrew R. Carey, Robert Fox, Thomas Grader‐Beck, Janet E. Lewis, Stephen Maitz, Steven Mandel, Astrid Rasmussen, George Sarka, R. Hal Scofield, Daniel J. Wallace, Rochelle Zak, Kristie Cox, Katherine M. Hammitt, Steven Carsons, Nancy Carteron   +21 more
wiley   +1 more source

Involvement of Notch1 inhibition in serum-stimulated glia and oligodendrocyte differentiation from human mesenchymal stem cells

Stem Cells and Cloning: Advances and Applications, 2010
Yi-Jang Lee1, Shih-Chieh Hung2–5, Mien-Sheng Chu41Department of Biomedical Imaging and Radiological Sciences, 2Institute of Clinical Medicine, 3Institute of Pharmacology, Faculty of Medicine, National Yang-Ming University, Taipei, Taiwan; 4Stem
Yi-Jang Lee, Shih-Chieh Hung, Mien-Sheng Chu   +2 more
doaj  

Functional activity of anti-LINGO-1 antibody opicinumab requires target engagement at a secondary binding site

mAbs, 2020
LINGO-1 is a membrane protein of the central nervous system (CNS) that suppresses myelination of axons. Preclinical studies have revealed that blockade of LINGO-1 function leads to CNS repair in demyelinating animal models. The anti-LINGO-1 antibody Li81
Karl J. M. Hanf, Joseph W. Arndt, YuTing Liu, Bang Jian Gong, Mia Rushe, Richelle Sopko, Ramiro Massol, Benjamin Smith, Yan Gao, Isin Dalkilic-Liddle, Xinhua Lee, Shanell Mojta, Zhaohui Shao, Sha Mi, R. Blake Pepinsky   +14 more
doaj   +1 more source

Differentiation of human fetal mesenchymal stem cells into cells with an oligodendrocyte phenotype [PDF]

, 2009
This article is available open access through the publisher’s website at the link below. Copyright @ 2009 Landes Bioscience.The potential of mesenchymal stem cells (MSC) to differentiate into neural lineages has raised the possibility of autologous cell ...
Waddington, S. N., Themis, M., Edwards, A. D.; id_orcid, Al-Allaf, F. A., Yeung, D, Pirianov, G., Mehmet, H, Nigel L. Kennea, Waddington, SN, Taylor, D. L., Chan, J., Fisk, NM, Keelin O’Donoghue, Simon N. Waddington, A. David Edwards, Pirianov, G, Fisk, N. M., Taylor, DL, Al-Allaf, FA, Deanna L. Taylor, Edwards, AD, Nicholas M. Fisk, Chan, J, Grisha Pirianov, O'Donoghue, K., Huseyin Mehmet, Mehmet, H., Yeung, D., Jerry Chan, Themis, M, Kennea, N. L., Michael Themis, O'Donoghue, K, Faisal A. Al-Allaf, Kennea, NL, Davy Yeung   +35 more
core   +1 more source

Anti‐Inflammatory and Neuroactive Effects of Polymer‐Coated Iron Oxide Nanoparticles Functionalized With Interleukin 4 for Spinal Cord Injury

Advanced Healthcare Materials, EarlyView.
Polymer‐coated IONPs functionalized with IL‐4 display respective neuroactive and anti‐inflammatory actions on neural progenitor cells and macrophages/microglia in vitro. When examined chronically in a rat experimental model of spinal cord injury, rGO scaffolds carrying these nanosystems adequately integrate into the lesion, significantly reduce ...
Julia Martínez‐Ramírez, Paloma Lozano‐Picazo, María de Lamo‐Atencia, Andrea Ferreras, Esther Benayas‐Martín, Elena Fernández‐López, Marina Sánchez‐Petidier, Verónica Barranco‐Maresca, Víctor Caz, Anne des Rieux, Juliana M. Rosa, María del Puerto Morales, María C. Serrano   +12 more
wiley   +1 more source

OLIG2 (oligodendrocyte lineage transcription factor 2)

, 2004
Review on OLIG2 (oligodendrocyte lineage transcription factor 2), with data on DNA, on the protein encoded, and where the gene is ...
D Rowitch, Rowitch, D
core   +1 more source

Oligodendrocyte precursor cell transplantation attenuates inflammation after ischemic stroke in mice

Frontiers in Neurology
BackgroundDisruption of blood–brain barrier and neuroinflammation are critical pathological features in the acute phase of ischemic stroke. This study investigates whether oligodendrocyte precursor cell transplantation can downregulate inflammation to ...
Li-Ping Wang, Li-Ping Wang, Chang Liu, Yuanyuan Ma, Aijuan Yan, Guo-Yuan Yang, Xinkai Qu, Wenshi Wei   +7 more
doaj   +1 more source

Alpha-Synuclein Expression in the Oligodendrocyte Lineage: an In Vitro and In Vivo Study Using Rodent and Human Models

Stem Cell Reports, 2015
In this study, we sought evidence for alpha-synuclein (ASYN) expression in oligodendrocytes, as a possible endogenous source of ASYN to explain its presence in glial inclusions found in multiple system atrophy (MSA) and Parkinson’s disease (PD).
Mehdi Djelloul, Staffan Holmqvist, Antonio Boza-Serrano, Carla Azevedo, Maggie S. Yeung, Stefano Goldwurm, Jonas Frisén, Tomas Deierborg, Laurent Roybon   +8 more
doaj   +1 more source