Results 61 to 70 of about 85,792 (299)

MicroRNA-Mediated Control of Oligodendrocyte Differentiation [PDF]

, 2010
SummaryMicroRNAs (miRNAs) regulate various biological processes, but evidence for miRNAs that control the differentiation program of specific neural cell types has been elusive.
He, Xuelian, Appel, Bruce, Xin, Mei, Chen, Ying, Lu, Q. Richard, Mi, Qing-Sheng, Ye, Feng, Yu, Yang, Xu, Xiaomei, Zhao, Xianghui, Han, Xiaolei, Hoang, ThaoNguyen, Wang, Fan   +12 more
core   +1 more source

Clinical and Modifiable Factors Associated With Disability and Relapse in MOGAD: A Multicentre Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Factors associated with relapse course and disability in myelin oligodendrocyte glycoprotein antibody‐associated disease (MOGAD) remain incompletely understood. Objectives To identify clinical and modifiable factors associated with relapse and disability in MOGAD. Methods In this ambispective multicentre cohort study using data from
Yingtao Wang, Shaoxin Tao, Qiujia Wang, Xiaoyu Xu, Hui Yao, Zheng Liu, Dawei Li, Zhandong Qiu, Jinming Han, Jiangwei Xia, Qi Wang, Jun Sun, Kai Shao, Jiao Li, Shishuang Ruan, Yi Zhong, Jun Guo, Shougang Guo, Yue Huang, Guoliang Chai, Tao Jin, Hongyu Zhou, Junwei Hao, Yinan Zhao   +23 more
wiley   +1 more source

Quantitative MRI Uncovers Subtle Cortical Damage in Myelin Oligodendrocyte Glycoprotein Antibody‐Associated Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine whether myelin‐sensitive quantitative MRI reveals microstructural abnormalities in normal‐appearing cortex (NACtx) in myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), indicating that conventional MRI underestimates remission residual cortical injury.
Valentina Camera, Agnese Tamanti, Silvia Messina, Nicola Dall'Osto, Teresa Maltempo, Stefano Ziccardi, Matteo Foschi, Maria Grazia Piscaglia, Diana Ferraro, Francesco Crescenzo, Francesca Rossi, Albulena Bajrami, Sabrina Marangoni, Damiano Marastoni, Francesca Benedetta Pizzini, Maria Isabel Leite, Roberta Magliozzi, Patrick Waters, Massimiliano Calabrese, Jacqueline Palace, Ruth Geraldes   +20 more
wiley   +1 more source

Mechanical plasticity during oligodendrocyte differentiation and myelination [PDF]

, 2017
In the central nervous system, oligodendrocyte precursor cells are exclusive in their potential to differentiate into myelinating oligodendrocytes. Oligodendrocyte precursor cells migrate within the parenchyma and extend cell membrane protrusions that ...
Rubinstein, Boris, Andrea Cruz, Pinto, Inês Mendes, Jonah R. Chan, Relvas, João B, Helena S. Domingues, Boris Rubinstein, Inês Mendes Pinto, Cruz, Andrea, Domingues, Helena S, Chan, Jonah R, João B. Relvas   +11 more
core   +1 more source

Primary oligodendrocyte death does not elicit anti-CNS immunity

, 2012
Anti-myelin immunity is commonly thought to drive multiple sclerosis, yet the initial trigger of this autoreactivity remains elusive. One of the proposed factors for initiating this disease is the primary death of oligodendrocytes.
Sobottka-Brillout, Bettina, Frommer, Friederike, Friederike Frommer, Karram, Khalad, Burkhard Becher, Wörtge, Simone, Waisman, Ari, Locatelli, Giuseppe, Simone Wörtge, Bühlmann, Claudia, Sobottka, Bettina, Ari Waisman, Martin Krüger, Bechmann, Ingo, Buch, Thorsten, Heppner, Frank L, Becher, Burkhard, Thorsten Buch, Frank L Heppner, Ingold, Barbara, Giuseppe Locatelli, Khalad Karram, Ingo Bechmann, Barbara Ingold, Bettina Sobottka, Claudia Bühlmann, Krüger, Martin   +26 more
core   +1 more source

Comparative Analysis of Choroid Plexus Volume Between MOG Antibody Associated Disease and Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Choroid plexus volume (CPV) has been proposed as a neuro‐immunological marker of multiple sclerosis (MS), but its relevance in myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD) remains uncertain. We analyzed CPV in 43 individuals with MOGAD, 48 with MS, and 44 healthy controls using a Bayesian Gaussian mixture modeling ...
Jae‐Won Hyun, Shaun G. Hong, Na Young Park, Su‐Hyun Kim, Ho Jin Kim   +4 more
wiley   +1 more source

Metabolic aspects of Neuronal – Oligodendrocytic - Astrocytic (NOA) interactions

Frontiers in Endocrinology, 2013
Whereas astrocytes have been in the limelight on the metabolic glucose interaction scene for a while, oligodendrocytes are still waiting for a place.
Ana I Amaral, Ana I Amaral, Tore Wergeland Meisingset, Mark R Kotter, Mark R Kotter, Ursula eSonnewald   +5 more
doaj   +1 more source

Smoothened/AMP-Activated Protein Kinase Signaling in Oligodendroglial Cell Maturation

Frontiers in Cellular Neuroscience, 2022
The regeneration of myelin is known to restore axonal conduction velocity after a demyelinating event. Remyelination failure in the central nervous system contributes to the severity and progression of demyelinating diseases such as multiple sclerosis ...
Alice Del Giovane, Mariagiovanna Russo, Linda Tirou, Hélène Faure, Martial Ruat, Sonia Balestri, Carola Sposato, Francesco Basoli, Alberto Rainer, Alberto Rainer, Abdelmoumen Kassoussi, Elisabeth Traiffort, Antonella Ragnini-Wilson   +12 more
doaj   +1 more source

Oligodendrocyte Regeneration and CNS Remyelination Require TACE/ADAM17

, 2015
The identification of the molecular network that supports oligodendrocyte (OL) regeneration under demyelinating conditions has been a primary goal for regenerative medicine in demyelinating disorders.
Aguirre, Adan, Klingener, Michael, Crawford, Howard, Palazuelos Diego, Javier, Raines, Elaine   +4 more
core   +1 more source

“Low‐Positive” MOG‐IgG Cases Among Adults With a First Event Suggestive of Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine the prevalence and clinical characteristics of patients with “low‐positive” (LP) MOG‐IgG (titres 1:160–1:320) among adults with a first demyelinating event (FDE) suggestive of multiple sclerosis (MS). Methods From the Barcelona CIS inception cohort, we included adult patients with serum collected ≤ 6 months from the FDE.
Javier Villacieros‐Álvarez, Carmen Espejo, Georgina Arrambide, Mireia Castillo, Marta Rodriguez, Helena Ariño, Iker Elosua, Carmen Tur, Angela Vidal‐Jordana, Andreu Vilaseca, Joaquín Castilló, Ingrid Galán, Luciana Midaglia, Carlos Nos, Breogan Rodríguez‐Acevedo, Ana Zabalza, Luca Bollo, Agustín Pappolla, René Carvajal, Neus Mongay‐Ochoa, Jordi Rio, Jaume Sastre‐Garriga, Manuel Comabella, Gesualdina Busiello, Sofia Sceppacuercia, Àlex Rovira, Xavier Montalban, Mar Tintoré, Cristina Auger, Álvaro Cobo‐Calvo   +29 more
wiley   +1 more source