Results 61 to 70 of about 108,437 (306)
Exogenous Leukemia Inhibitory Factor Stimulates Oligodendrocyte Progenitor Cell Proliferation and Enhances Hippocampal Remyelination [PDF]
, 2012 New CNS neurons and glia are generated throughout adulthood from endogenous neural stem and progenitor cells. These progenitors can respond to injury, but their ability to proliferate, migrate, differentiate, and survive is usually insufficient to ...
Deverman, Benjamin E. +1 more
core +1 more source
Oligodendrocytes: biology and pathology [PDF]
Acta Neuropathologica, 2009 Oligodendrocytes are the myelinating cells of the central nervous system (CNS). They are the end product of a cell lineage which has to undergo a complex and precisely timed program of proliferation, migration, differentiation, and myelination to finally produce the insulating sheath of axons.
Bradl, Monika, Lassmann, Hans
openaire +2 more sources
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To investigate the value of constructing models based on habitat radiomics and pathomics for predicting the risk of progression in high‐grade gliomas. Methods This study conducted a retrospective analysis of preoperative magnetic resonance (MR) images and pathological sections from 72 patients diagnosed with high‐grade gliomas (52 ...
Yuchen Zhu +14 more
wiley +1 more source
Mutation of pescadillo disrupts oligodendrocyte formation in zebrafish.
PLoS ONE, 2012 BackgroundIn vertebrates, the myelin sheath is essential for efficient propagation of action potentials along the axon shaft. Oligodendrocytes are the cells of the central nervous system that create myelin sheaths.
Timothy Simmons, Bruce Appel
doaj +1 more source
Mechanisms involved in the remyelinating effect of sildenafil [PDF]
, 2018 Remyelination occurs in demyelinated lesions in multiple sclerosis (MS) and pharmacological treatments that enhance this process will critically impact the long term functional outcome in the disease.
Díaz-Lucena, Daniela +5 more
core +1 more source
Sleep and Oligodendrocyte Functions [PDF]
Current Sleep Medicine Reports, 2015 Transcriptomic studies have revealed that the brains of sleeping and awake animals differ significantly at the molecular level, with hundreds of brain transcripts changing their expression across behavioral states. However, it was unclear how sleep affects specific cells types, such as oligodendrocytes, which make myelin in the healthy brain and in ...
openaire +3 more sources
Centenary of the oligodendrocyte
The Lancet Neurology, 2021 “At the banquet of medicine, [histology] is the guest of honor, who eats little—aloof, mysterious—to whom all listen, yet whom very few understand.”1 For Pío del Río-Hortega (Spain, 1882–Argentina, 1945), histology blended the cold and factual with the dynamic, romantic artistry that brought the subject to light.
James, Owen G +3 more
openaire +4 more sources
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Glioma recurrence severely impacts patient prognosis, with current treatments showing limited efficacy. Traditional methods struggle to analyze recurrence mechanisms due to challenges in assessing tumor heterogeneity, spatial dynamics, and gene networks.
Lei Qiu +10 more
wiley +1 more source
The Many Hats of Sonic Hedgehog Signaling in Nervous System Development and Disease. [PDF]
, 2016 Sonic hedgehog (Shh) signaling occurs concurrently with the many processes that constitute nervous system development. Although Shh is mostly known for its proliferative and morphogenic action through its effects on neural stem cells and progenitors, it ...
Belgacem, Yesser H +4 more
core +2 more sources
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Introduction Spinal cord infarction (SCI) is a rare but devastating myelopathy, characterized by a high disability rate and an unfavorable prognosis. It has often been underdiagnosed and misdiagnosed as idiopathic transverse myelitis (ITM). This study aimed to describe the clinical features, radiological biomarkers, treatments, and functional ...
Zeqiang Ji +13 more
wiley +1 more source