Results 81 to 90 of about 66,933 (261)
Advanced Science, EarlyView.Chronic stress disrupts copper homeostasis and promotes copper accumulation in the prelimbic cortex, leading to astrocytic FDX1 upregulation. Elevated astrocytic FDX1 impairs calcium signaling, induces structural atrophy, and disrupts synaptic function, contributing to depressive‐like behaviors. Physical exercise reverses these alterations by restoring
Lina Gao +11 more
wiley +1 more source
Advanced Science, EarlyView.Adult stem cell therapy requires more than high in vitro potency. This review proposes a systems framework in which cell‐intrinsic programs, instructive microenvironmental cues, and pre‐/post‐delivery engineering are co‐designed under standardized translational rules.
Soo‐Rim Kim +2 more
wiley +1 more source
Mood Disorder Begins in the Mouth: Periodontitis Mediates Anxiety‐Like Behaviors
Advanced Science, EarlyView.ABSTRACT The previous study elucidated that the C‐reactive protein (CRP)/bone morphogenetic protein 4 (BMP4) signaling pathway mediates periodontitis‐associated anxiety‐like behaviors in rats. This molecular crosstalk along the periodontal‐hippocampal axis provides novel insights into the etiology and mechanisms of emotional disorders. However, several
Zhigang Chen, Xing Li
wiley +1 more source
Illuminating the Intracellular World: Breakthroughs in Nanoscale Optoelectronics
Advanced Electronic Materials, EarlyView.This perspective explores optoelectronic biointerfaces spanning macroscale flexible devices to nanoscale intracellular systems, emphasizing their integration across dimensions. It examines capacitive, Faradaic, and photothermal mechanisms that enable light‐driven control of cellular activity and highlights key material and design challenges in ...
Tania Assaf, Menahem Y. Rotenberg
wiley +1 more source
Brain Sciences, 2019 Type 2 diabetes is associated with diabetic cognopathy. Anti-hyperglycemic sodium glucose transporter 2 (SGLT2) inhibitors have shown promise in reducing cognitive impairment in mice with type 2 diabetes mellitus.
Melvin R. Hayden +3 more
doaj +1 more source
Composition‐Aware Cross‐Sectional Integration for Spatial Transcriptomics
Advanced Intelligent Discovery, EarlyView.Multi‐section spatial transcriptomics demands coherent cell‐type deconvolution, domain detection, and batch correction, yet existing pipelines treat these tasks separately. FUSION unifies them within a composition‐aware latent framework, modeling reads as cell‐type–specific topics and clustering in embedding space.
Qishi Dong +5 more
wiley +1 more source
Frontiers in Cellular NeuroscienceOligodendrocyte-lineage cells are central nervous system (CNS) glia that perform multiple functions including the selective myelination of some but not all axons.
James R. Gronseth +9 more
doaj +1 more source
Frontiers in Pharmacology, 2019 Growing evidence has implicated that myelin deficits and neuroinflammation are the coexisted pathological features that contribute to the mood swing and cognitive decline in major depressive disorder (MDD) and multiple sclerosis (MS).
Yanbo Zhang +8 more
doaj +1 more source
Yin Yang 1 Specifically Supports the Development of Olig2 Positive Cerebellar Astrocytes. [PDF]
GliaCerebellar Olig2 positive astrocytes are most abundant in the cerebellar nuclei. Cerebellar astrocytes expressing Olig2 have unique gene expression profiles. Yin Yang 1 specifically supports the development of astrocytes expressing Olig2. Deletion of YY1 during development increases numbers of astrocytes expressing Olig2 but hinders their ...
Zarei-Kheirabadi M +9 more
europepmc +2 more sources
The 9th International RASopathies Symposium
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT The RASopathies are a group of congenital disorders with overlapping clinical manifestations that are caused by pathogenic germline or early somatic variants that result in the hyperactivation of the RAS/mitogen‐activated protein kinase (MAPK) signaling pathway.
Pau Castel +41 more
wiley +1 more source