Results 101 to 110 of about 88,065 (299)

The Landscape of Gene Expression and Molecular Regulation Following Spinal Cord Hemisection in Rats

Frontiers in Molecular Neuroscience, 2019
Spinal cord injury (SCI) is a challenging clinical problem worldwide. The cellular state and molecular expression in spinal cord tissue after injury are extremely complex and closely related to functional recovery.
Bin Yu, Bin Yu, Chun Yao, Yongjun Wang, Susu Mao, Yaxian Wang, Ronghua Wu, Wei Feng, Yanping Chen, Jian Yang, Chengbin Xue, Dong Liu, Fei Ding, Xiaosong Gu, Xiaosong Gu   +14 more
doaj   +1 more source

Neuronal Influence on Oligodendrocyte Differentiation [PDF]

Proper myelination in the central nervous system requires coordinated interactions between neurons and oligodendrocytes during brain development. SATB2 (Special AT-rich sequence-binding protein 2) is a critical transcription factor essential for cortical
Esparza, Alexander
core  

MethyAnno: An Interpretable Automated Annotation Method Leveraging Multi‐Scale Information and Metric Learning Framework for scDNAm Data

Advanced Science, EarlyView.
MethyAnno enables robust and interpretable annotation of single‐cell DNA methylation data by integrating multi‐scale epigenetic information, bidirectional cross‐attention, and prototype‐based metric learning. The framework resolves rare and novel cell types across datasets while revealing cell‐type‐specific epigenetic signatures associated with disease
Yuhang Jia, Siyu Li, Songming Tang, Keju Gu, Shengquan Chen   +4 more
wiley   +1 more source

Antibodies utilized for oligodendrocyte lineage cell characterization by flow cytometry.

, 2014
Antibodies utilized for oligodendrocyte lineage cell characterization by flow cytometry.
Andrew P. Robinson (633048), Stephen D. Miller (353521), Gwendolyn E. Goings (633050), Jane M. Rodgers (633049)   +3 more
core   +1 more source

Activin receptors regulate the oligodendrocyte lineage in health and disease [PDF]

, 2018
The most prevalent neurological disorders of myelin include perinatal brain injury leading to cerebral palsy in infants and multiple sclerosis in adults.
Soong, Daniel; id_orcid, Frances L. Evans, Marie E. Bechler, Rebecca K. Holloway, Miron, Veronique E, Dillenburg, Alessandra, Gloria H. Su, Graeme Ireland, Daniel Soong, Smith, Colin; id_orcid, Evans, Frances L, Swire, Matthew, Su, Gloria H, Dillenburg Scur, Alessandra, Ireland, Graeme, Yuen, Tracy J, Tracy J. Yuen, Bechler, Marie E, Alessandra Dillenburg, Holloway, Rebecca K, Claire L. Davies, Davies, Claire L, Matthew Swire, Colin Smith, Anna Williams, Becher, Julie-Clare, Julie-Clare Becher, Veronique E. Miron, Williams, Anna   +28 more
core   +1 more source

Targeting LDHA Palmitoylation Sensitizes GBM to Chemoradiotherapy via Suppressing Palmitic Acid Induced Glycolytic Reprogramming

Advanced Science, EarlyView.
Mesenchymal GSCs preferentially uptake palmitic acid, thereby promoting ZDHHC12‐mediated LDHA palmitoylation. This modification enhances LDHA enzymatic activity, drives glycolytic reprogramming, and facilitates exosomal LDHA‐mediated TAM regulation.
Zijie Gao, Rongrong Zhao, Zheyuan Chen, Qingtong Wang, Huanyu Yang, Boyan Li, Yanhua Qi, Shulin Zhao, Jixing Zhao, Jiawei Qiu, Ziwen Pan, Zhe Han, Ruochuan Li, Huize Xia, Weijie Tang, Xing Guo, Ping Zhang, Hongyu Zhao, Xu Qian, Gang Li, Hao Xue   +20 more
wiley   +1 more source

Glial Cells in the Fish Retinal Nerve Fiber Layer Form Tight Junctions, Separating and Surrounding Axons

Frontiers in Molecular Neuroscience, 2018
In the retina of teleost fish, cell addition continues throughout life involving proliferation and axonal growth. To study how this is achieved in a fully functioning retina, we investigated the nerve fiber layer (NFL) of the cichlid fish Astatotilapia ...
Lidia Garcia-Pradas, Corinna Gleiser, Andrea Wizenmann, Hartwig Wolburg, Andreas F. Mack   +4 more
doaj   +1 more source

Nrsn1–Smarcc1 Coupling Regulates Neural Stem Cell Differentiation and Chronic‐phase Recovery After Ischemic Stroke

Advanced Science, EarlyView.
In the post‐stroke brain, Foxa2 induces the transcriptional upregulation of Nrsn1 in NSCs. Nrsn1 functionally couples with Smarcc1, modulating its nuclear availability and protein abundance, thereby influencing Smarcc1‐associated regulatory programs linked to neuronal lineage commitment. Through this coupling, Nrsn1 promotes the differentiation of NSCs
Ruolin Zhang, Chang Liu, Yuneng Zhou, Kaichen Zhao, Muyang Li, Bingcheng Cai, Ying Wang, Zhiyuan Yuan, Zhaoxin Liu, Zilong Yuan, Yao Xiao, Peiyang Zhou, Ke Shui, Wendai Bao, Min Zhang, Jun Qin, Jun Chen, Xin Yang, Zhiqiang Dong   +18 more
wiley   +1 more source

Primary oligodendrocyte death does not elicit anti-CNS immunity.

, 2012
Anti-myelin immunity is commonly thought to drive multiple sclerosis, yet the initial trigger of this autoreactivity remains elusive. One of the proposed factors for initiating this disease is the primary death of oligodendrocytes.
Sobottka-Brillout, Bettina, Frommer, Friederike, Friederike Frommer, Karram, Khalad, Burkhard Becher, Wörtge, Simone, Waisman, Ari, Locatelli, Giuseppe, Simone Wörtge, Bühlmann, Claudia, Sobottka, Bettina, Ari Waisman, Martin Krüger, Bechmann, Ingo, Buch, Thorsten, Heppner, Frank L, Becher, Burkhard, Thorsten Buch, Frank L Heppner, Ingold, Barbara, Giuseppe Locatelli, Khalad Karram, Ingo Bechmann, Barbara Ingold, Bettina Sobottka, Claudia Bühlmann, Krüger, Martin, Locatelli, G;Wörtge, S;Buch, T;Ingold, B;Frommer, F;Sobottka, B;Krüger, M;Karram, K;Bühlmann, C;Bechmann, I;Heppner, FL;Waisman, A;Becher, B, Bühlmann C, Locatelli G, Sobottka B, Frommer F, Waisman A, Wörtge S, Krüger M, Bechmann I, Heppner FL, Becher B, Ingold B, Buch T, Karram K   +40 more
core   +1 more source

Molecular Glue Degraders Enhance CAPRIN1‐Dependent Lysosomal Degradation of APP and Reduce Amyloid β in Alzheimer's Disease

Advanced Science, EarlyView.
A new class of lysosome‐directed molecular glue degraders selectively enhance CAPRIN1–APP interactions, driving APP degradation and reducing amyloid‐β production in human neurons and Alzheimer's disease mouse models. This CAPRIN1‐dependent targeted protein degradation strategy reveals a previously unrecognized therapeutic approach for disrupting the ...
Sunghan Jung, Xu Wang, Bin Liu, Raktim Roy, Nancy Jaiswal, Ratan K. Rai, Yuichiro Takagi, Cen Gao, Lifan Zeng, Ho‐Yin Lo, Reagan K. Wohlford, Ryan K. Higgins, Bruce T. Lamb, Anantha Shekhar, Anita C. Bellail, Chunhai Hao   +15 more
wiley   +1 more source