Results 11 to 20 of about 66,933 (261)
Mechanosensitivity of Human Oligodendrocytes [PDF]
Frontiers in Cellular Neuroscience, 2020 Oligodendrocytes produce and repair myelin, which is critical for the integrity and function of the central nervous system (CNS). Oligodendrocyte and oligodendrocyte progenitor cell (OPC) biology is modulated in vitro by mechanical cues within the ...
Daniela Espinosa-Hoyos +10 more
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Histone demethylase KDM6B promotes postnatal oligodendrocyte maturation and cortical myelination [PDF]
Frontiers in Cellular NeuroscienceIntroductionPostnatal cortical myelination requires epigenetic activation of oligodendrocyte gene programs, but the role of histone demethylases in vivo remains unclear.MethodsWe conditionally deleted Kdm6b in Emx1+ dorsal telencephalic progenitors and ...
Ruth Lambries +4 more
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eLife, 2023 In the developing central nervous system, oligodendrocyte precursor cells (OPCs) differentiate into oligodendrocytes, which form myelin around axons. Oligodendrocytes and myelin are essential for the function of the central nervous system, as evidenced ...
Lin Pan +7 more
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Oligodendrocytes in a Nutshell [PDF]
Frontiers in Cellular Neuroscience, 2015 Oligodendrocytes are the myelinating cells of the central nervous system (CNS). While the phrase is oft repeated and holds true, the last few years have borne witness to radical change in our understanding of this unique cell type. Once considered static glue, oligodendrocytes are now seen as plastic and adaptive, capable of reacting to a changing CNS.
John-Paul eMichalski +5 more
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Centenary of the oligodendrocyte
The Lancet Neurology, 2021 “At the banquet of medicine, [histology] is the guest of honor, who eats little—aloof, mysterious—to whom all listen, yet whom very few understand.”1 For Pío del Río-Hortega (Spain, 1882–Argentina, 1945), histology blended the cold and factual with the dynamic, romantic artistry that brought the subject to light.
James, Owen G +3 more
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The immunomodulatory oligodendrocyte [PDF]
Brain Research, 2016 Oligodendrocytes, the myelinating glial cells of the central nervous system (CNS), are due to their high specialization and metabolic needs highly vulnerable to various insults. This led to a general view that oligodendrocytes are defenseless victims during brain damage such as occurs in acute and chronic CNS inflammation.
Zeis, Thomas +2 more
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Cells, 2022 Emerging evidence has implicated non-neuronal cells, particularly oligodendrocytes, in the pathophysiology of many neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, Huntington’s disease and ...
Kristen H. Schuster +2 more
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Oligodendrocytes in Schizophrenia [PDF]
Schizophrenia Research and Treatment, 2011 Despite the many neuroimaging studies that suggest gray matter volume reductions in schizophrenia, there is no compelling postmortem evidence to suggest neuronal loss, nor is there a distinctive or specific signature of gray matter abnormalities in schizophrenia.
Xu, Haiyun +3 more
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Nature Reviews Neuroscience, 2006 Oligodendrocyte precursors first arise in a restricted ventral part of the embryonic spinal cord and migrate laterally and dorsally from there. Later, secondary sources develop in the dorsal cord. Normally, the ventrally-derived precursors compete with and suppress their dorsal counterparts.
William D, Richardson +2 more
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Oligodendrocyte precursor cell maturation: role of adenosine receptors
Neural Regeneration Research, 2021 Oligodendrocyte-formed myelin sheaths allow fast synaptic transmission in the brain and their degeneration leads to demyelinating diseases such as multiple sclerosis.
Federica Cherchi +2 more
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