Results 11 to 20 of about 85,792 (299)

Phosphorylation State of ZFP24 Controls Oligodendrocyte Differentiation

Cell Reports, 2018
Summary: Zinc finger protein ZFP24, formerly known as ZFP191, is essential for oligodendrocyte maturation and CNS myelination. Nevertheless, the mechanism by which ZFP24 controls these processes is unknown.
Benayahu Elbaz, Joshua D. Aaker, Sara Isaac, Anna Kolarzyk, Pedro Brugarolas, Amir Eden, Brian Popko   +6 more
doaj   +2 more sources

Mutation of pescadillo disrupts oligodendrocyte formation in zebrafish.

PLoS ONE, 2012
BackgroundIn vertebrates, the myelin sheath is essential for efficient propagation of action potentials along the axon shaft. Oligodendrocytes are the cells of the central nervous system that create myelin sheaths.
Timothy Simmons, Bruce Appel
doaj   +2 more sources

Stalled oligodendrocyte differentiation in IDH-mutant gliomas

Genome Medicine, 2023
Background Roughly 50% of adult gliomas harbor isocitrate dehydrogenase (IDH) mutations. According to the 2021 WHO classification guideline, these gliomas are diagnosed as astrocytomas, harboring no 1p19q co-deletion, or oligodendrogliomas, harboring ...
Yanfei Wei, Guanzhang Li, Jing Feng, Fan Wu, Zheng Zhao, Zhaoshi Bao, Wei Zhang, Xiaodong Su, Jiuyi Li, Xueling Qi, Zejun Duan, Yunqiu Zhang, Sandra Ferreyra Vega, Asgeir Store Jakola, Yingyu Sun, Helena Carén, Tao Jiang, Xiaolong Fan   +17 more
doaj   +2 more sources

Myelin basic protein peptide 45–89 induces the release of nitric oxide from microglial cells. [PDF]

, 2002
Continuous (24 h) exposure of mixed oligodendrocyte/microglial cells to peptides 45–89 derived from citrullinated C8 isoforms of myelin basic protein (MBP) induces cell death.
Pichkhadze, B., Machaidze, G., Mikeladze, D., Shanshiashvili, L., Ramsden, Jeremy J.   +4 more
core   +7 more sources

Region Specific miRNA-mRNA Networks in Gray and White Matter Lesions of Progressive Multiple Sclerosis. [PDF]

Ann Clin Transl Neurol
ABSTRACT Objective Multiple sclerosis (MS) is a neurodegenerative demyelinating disease of the central nervous system. This study aimed to identify micro‐RNA (miRNA)–mRNA regulatory networks underlying region‐specific molecular mechanisms in white matter and gray matter lesions in progressive MS.
Sapra A, Rai NK, Niepokny TD, Courtney H, Tripathi A, Dutta R.   +5 more
europepmc   +2 more sources

Centenary of the oligodendrocyte

The Lancet Neurology, 2021
“At the banquet of medicine, [histology] is the guest of honor, who eats little—aloof, mysterious—to whom all listen, yet whom very few understand.”1 For Pío del Río-Hortega (Spain, 1882–Argentina, 1945), histology blended the cold and factual with the dynamic, romantic artistry that brought the subject to light.
James, Owen G, Mehta, Arpan R, Behari, Madhuri, Chandran, Siddharthan   +3 more
openaire   +4 more sources

Intranasal Administration of Undifferentiated Oligodendrocyte Lineage Cells as a Potential Approach to Deliver Oligodendrocyte Precursor Cells into Brain [PDF]

, 2021
Oligodendrocyte precursor cell (OPC) migration is a mechanism involved in remyelination; these cells migrate from niches in the adult CNS. However, age and disease reduce the pool of OPCs; as a result, the remyelination capacity of the CNS decreases over
Vidorreta Ballesteros, Lucía, Inmaculada Sanclemente-Alamán, Doddy Denise Ojeda-Hernández, Matias Guiu, Jordi A., María Soledad Benito-Martín, Jorge Matías-Guiu, Benito Martín, María Soledad, Ojeda Hernández, Doddy Denise, Sara Pérez-Suarez, Mateos Díaz, Juan Carlos, Selma Calvo, Belen, Montero Escribano, Paloma, Juan Carlos Mateos-Díaz, Mercedes A. Hernández-Sapiéns, Francisco Sancho-Bielsa, Lucía Vidorreta-Ballesteros, Pérez Suárez:, Sara, Ulises Gómez-Pinedo, Edwin E. Reza-Zaldívar, Lidia Moreno-Jiménez, Matías-Guiu Guía, Jorge, Hernández Sapiéns, Mercedes A., Alejandro Canales-Aguirre, Jordi A. Matías-Guiu, Belen Selma-Calvo, Paloma Montero-Escribano, Reza Zaldívar, Edwin E., Moreno Jiménez, Lidia, Gómez Pinedo, Ulises, Sancho Bielsa, Francisco, Sanclemente Alamán, Inmaculada, Canales Aguirre, Alejandro   +31 more
core   +1 more source

Oligodendrocytes in a Nutshell [PDF]

Frontiers in Cellular Neuroscience, 2015
Oligodendrocytes are the myelinating cells of the central nervous system (CNS). While the phrase is oft repeated and holds true, the last few years have borne witness to radical change in our understanding of this unique cell type. Once considered static glue, oligodendrocytes are now seen as plastic and adaptive, capable of reacting to a changing CNS.
John-Paul eMichalski, John-Paul eMichalski, Rashmi eKothary, Rashmi eKothary, Rashmi eKothary, Rashmi eKothary   +5 more
openaire   +3 more sources

The immunomodulatory oligodendrocyte [PDF]

Brain Research, 2016
Oligodendrocytes, the myelinating glial cells of the central nervous system (CNS), are due to their high specialization and metabolic needs highly vulnerable to various insults. This led to a general view that oligodendrocytes are defenseless victims during brain damage such as occurs in acute and chronic CNS inflammation.
Zeis, Thomas, Enz, Lukas, Schaeren-Wiemers, Nicole   +2 more
openaire   +4 more sources

Oligodendrocyte wars [PDF]

Nature Reviews Neuroscience, 2006
Oligodendrocyte precursors first arise in a restricted ventral part of the embryonic spinal cord and migrate laterally and dorsally from there. Later, secondary sources develop in the dorsal cord. Normally, the ventrally-derived precursors compete with and suppress their dorsal counterparts.
William D, Richardson, Nicoletta, Kessaris, Nigel, Pringle   +2 more
openaire   +2 more sources