Results 151 to 160 of about 12,307 (190)

Enantio-oligodeoxyribonucleotides.

Nucleic acids symposium series, 1991
As a sugar-modified oligonucleotide, a hexamer of 9-(2-deoxy-beta-L-erythro-pentafuranosyl)-9H-purin-6-amine, [L-(dAp)5dA], was synthesized by triester method. The L-hexamer was resistant to bovine spleen phosphodiesterase. UV absorption studies indicated that L-hexamer formed a complex with poly U but not with poly dT at 0 degrees C.
S, Fujimori, K, Shudo, Y, Hashimoto
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Meso-oligodeoxyribonucleotides.

Nucleic acids symposium series, 1993
Meso-DNAs, containing L-sugar and D-sugar in an alternate sequence as the backbone [Fig. 1, designated as LD-(dN)n], were prepared as a modificated oligonucleotides of natural- and enantio-DNA. The characteristics of meso-DNAs were analyzed, focusing on LD-(dA)n and LD-(dT)n.
O N, Iwanami, K, Shudo, Y, Hashimoto
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Phosphite Synthesis of Oligodeoxyribonucleotides

Russian Chemical Reviews, 1988
Data in the literature published between 1983 and 1986 on the synthesis of oligodeoxyribonucleotides from nucleoside derivatives of phosphorous acid are reviewed. Attention is mainly focused on the techniques employed for preparing initial monomers for condensation.
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Synthesis of Oligodeoxyribonucleotides Containing Oleylamine Moieties

Russian Journal of Bioorganic Chemistry, 2001
A method for directional introduction of oleylamine residues to any position of oligodeoxyribonucleotides during their automated synthesis was developed. The presence of oleylamine residues in 3'- or 5'-terminal nucleotides was shown to have no effect on the thermodynamic stability of DNA duplexes formed by such oligonucleotides and the complementary ...
S Iu, Andreev, S I, Antsypovich, E M, Volkov, E A, Romanova, T, Hianik, T S, Oretskaia   +5 more
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The automated synthesis of oligodeoxyribonucleotides

Trends in Biotechnology, 1985
Abstract Progress in science is a history of the synergistic relationship between technology and theory: growth in theoretical understanding requires and initiates technological change; technological advance opens up new areas of knowledge. The history of molecular genetics is but a single illustration of this process.
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Synthesis and Biochemical Evaluation of Phosphonoformate Oligodeoxyribonucleotides

Journal of the American Chemical Society, 2006
Phosphonoformate oligodeoxyribonucleotides were prepared via a solid phase synthesis strategy. The first step in the preparation of appropriate synthons was condensation of bis(N,N-diisopropylamino)phosphine and diphenylmethylsilylethyl chloroformate in the presence of sodium metal to yield formic acid, [bis(N,N-diisopropylamino)phosphino]-beta ...
Christina M, Yamada, Douglas J, Dellinger, Marvin H, Caruthers   +2 more
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Random mutagenesis using degenerate oligodeoxyribonucleotides

Gene, 1988
An efficient method for random mutagenesis was applied to a 75-bp target sequence. The mutational changes in the target region are introduced by the technique of oligodeoxyribonucleotide(oligo)-directed, site-specific mutagenesis using mixtures of degenerate oligos.
Hübner P, Iida S, Arber W
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Structural requirements and applications of inhibitory oligodeoxyribonucleotides

Immunologic Research, 2007
Synthetic oligodeoxyribonucleotides (ODN) bearing certain sequence characteristics mimic bacterial DNA by activating B cells and dendritic cells through Toll-like receptor (TLR) 9, an event that potentiates both humoral and cell-mediated immunity. ODN sharing some of the sequence characteristics of strong stimulatory (ST-) ODN, but substituting GGG for
Robert F, Ashman, Petar, Lenert
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Use of an aminooxy linker for the functionalization of oligodeoxyribonucleotides

Bioorganic & Medicinal Chemistry Letters, 2001
We describe the preparation of oligonucleotides containing a 5'-linker bearing an aminooxy group. Use of the trityl protecting group for the aminooxy moiety allows purification of the modified oligonucleotide by reverse phase HPLC and cleavage in mild acidic conditions. Derivatization with an aldehydic reporter group is efficient and rapid.
E, Defrancq, J, Lhomme
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Enantio- and meso-oligodeoxyribonucleotides.

Nucleic acids symposium series, 1992
As sugar-modified oligodeoxyribonucleotides, L-homooligomers (L-dA12 and L-dT12) and a L/D-alternative oligomer ((L-dA-D-dA)6) were synthesized. These oligomers were quite resistant towards phosphodiesterase degradations. L-dA12 formed complexes with poly(dT) and poly(U) at 0 degree C with different stabilities, on the other hand L-dT12 did not show ...
S, Fujimori, N, Iwanami, K, Shudo, Y, Hashimoto   +3 more
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