Results 151 to 160 of about 11,432 (197)

PEG-Supported Synthesis of Cyclic Oligodeoxyribonucleotides

Nucleosides and Nucleotides, 1993
Abstract Cyclic oligodeoxyribonucleotides have been synthesized in satisfactory yields by an easy procedure using polyethylene glycol (PEG) as soluble supporting polymer. The present method is particularly suitable for a medium to large scale synthesis.
DE NAPOLI, LORENZO, A. MESSERE, MONTESARCHIO, DANIELA, PICCIALLI, GENNARO, C. SANTACROCE, G. M. BONORA   +5 more
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Synthesis of cyclic branched oligodeoxyribonucleotides

, 1991
The synthesis of two cyclic branched oligonucleotides, a trimer and a tetramer of thymidylic acid, has been successfully achieved exploiting a phosphotriester-based synthetic protocol.
DE NAPOLI, LORENZO, MONTESARCHIO, DANIELA, PICCIALLI, GENNARO, C. Santacroce, A. Messere   +4 more
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An efficient method for the sequence analysis of oligodeoxyribonucleotides

Analytical Biochemistry, 1983
Modifications of the chemical method of DNA sequence analysis that permit rapid and reliable sequence determination of single-stranded oligodeoxyribonucleotides as short as 4 nucleotides in length are reported. The principal changes made were increasing the level of chemical modification and optimizing the conditions for recovery of the chemically ...
Marek Michalak, Bernard R Glick
exaly   +3 more sources

Improved synthesis of oligodeoxyribonucleotides

Tetrahedron Letters, 1990
An improved synthesis of oligodeoxyribonucleotides was achieved with NPE- and NPEOC-protected phosphoramidites leading to easier and time-saving purification and isolation of the gene fragments.
K P, Stengele, W, Pfleiderer
openaire   +2 more sources

A Chemical 5′-Phosphorylation of Oligodeoxyribonucleotides

DNA, 1986
To circumvent the use of T4 polynucleotide kinase and ATP for the 5′-phosphorylation of synthetic oligodeoxyribonucleotides after deprotection and purification, we have developed a new chemical phosphorylation reagent that can be used on automated DNA synthesis instruments. The phosphite-derived compound, bis(β-cyanoethoxy)-
T, Horn, M S, Urdea
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Selective modification of cytosines in oligodeoxyribonucleotides

Bioconjugate Chemistry, 1992
A single deoxycytidine residing in an oligodeoxyribonucleotide which also contains 5-methyldeoxycytidines can be selectively derivatized with various alkylamines by sodium bisulfite-catalyzed transamination. Selective transamination results because 5-methylcytosine, unlike cytosine, does not form a bisulfite adduct.
P S, Miller, C D, Cushman
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Versatile synthesis of oligodeoxyribonucleotide–oligospermine conjugates

Nature Protocols, 2007
A protocol for the rapid, automated synthesis of oligospermine-oligonucleotide sequences is described. To this end, a protected spermine phosphoramidite derivative was synthesized in six steps from spermine and used as the fifth synthon in an oligonucleotide synthesizer. Parameters were optimized to reach greater than 95% coupling yields.
Voirin, E., Kotera, M., Behr, J.P.
openaire   +3 more sources

PHOSPHONOACETATE DERIVATIVES OF OLIGODEOXYRIBONUCLEOTIDES

Nucleosides and Nucleotides, 1996
Abstract A deoxyribodinucleotide phosphonoacetate derivative has been prepared, separated into individual diastereomers, and incorporated into oligodeoxyribonucleotides possessing alternating phosphodiester and phosphonoacetate backbone linkages. The hybridization properties and enzymatic stabilities of these oligonucleotides have been studied.
M Jonathan Rudolph, Michael S. Reitman, Eric W MacMillan, Alan F. Cook   +3 more
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Red light activated phosphothioate oligodeoxyribonucleotides

Collection Symposium Series, 2008
Hairpin-structured phosphorothioate oligodeoxyribonucleotides containing a singlet oxygen-sensitive linker in the loop were prepared. These compounds do not bind complementary nucleic acids in the dark. Upon irradiation with red light in the presence of chlorine e6 the linker within these compounds is cleaved and a single-stranded ...
Alexandru, Rotaru, János, Kovács, Andriy, Mokhir   +2 more
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Meso-oligodeoxyribonucleotides.

Nucleic acids symposium series, 1993
Meso-DNAs, containing L-sugar and D-sugar in an alternate sequence as the backbone [Fig. 1, designated as LD-(dN)n], were prepared as a modificated oligonucleotides of natural- and enantio-DNA. The characteristics of meso-DNAs were analyzed, focusing on LD-(dA)n and LD-(dT)n.
O N, Iwanami, K, Shudo, Y, Hashimoto
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