Results 171 to 180 of about 4,788 (197)

Synthesis and Biochemical Evaluation of Phosphonoformate Oligodeoxyribonucleotides

Journal of the American Chemical Society, 2006
Phosphonoformate oligodeoxyribonucleotides were prepared via a solid phase synthesis strategy. The first step in the preparation of appropriate synthons was condensation of bis(N,N-diisopropylamino)phosphine and diphenylmethylsilylethyl chloroformate in the presence of sodium metal to yield formic acid, [bis(N,N-diisopropylamino)phosphino]-beta ...
Christina M, Yamada, Douglas J, Dellinger, Marvin H, Caruthers   +2 more
openaire   +2 more sources

Random mutagenesis using degenerate oligodeoxyribonucleotides

Gene, 1988
An efficient method for random mutagenesis was applied to a 75-bp target sequence. The mutational changes in the target region are introduced by the technique of oligodeoxyribonucleotide(oligo)-directed, site-specific mutagenesis using mixtures of degenerate oligos.
Hübner P, Iida S, Arber W
openaire   +3 more sources

Use of an aminooxy linker for the functionalization of oligodeoxyribonucleotides

Bioorganic & Medicinal Chemistry Letters, 2001
We describe the preparation of oligonucleotides containing a 5'-linker bearing an aminooxy group. Use of the trityl protecting group for the aminooxy moiety allows purification of the modified oligonucleotide by reverse phase HPLC and cleavage in mild acidic conditions. Derivatization with an aldehydic reporter group is efficient and rapid.
E, Defrancq, J, Lhomme
openaire   +2 more sources

Enantio- and meso-oligodeoxyribonucleotides.

Nucleic acids symposium series, 1992
As sugar-modified oligodeoxyribonucleotides, L-homooligomers (L-dA12 and L-dT12) and a L/D-alternative oligomer ((L-dA-D-dA)6) were synthesized. These oligomers were quite resistant towards phosphodiesterase degradations. L-dA12 formed complexes with poly(dT) and poly(U) at 0 degree C with different stabilities, on the other hand L-dT12 did not show ...
S, Fujimori, N, Iwanami, K, Shudo, Y, Hashimoto   +3 more
openaire   +1 more source

Chemical Synthesis of Oligodeoxyribonucleotides

1987
Oligodeoxyribonucleotides of defined sequence may now be synthesised as a matter of routine at a reasonable cost in both time and materials. As both applications of and synthetic methods for oligodeoxyribonucleotides are much more highly developed than those for oligoribonucleotides, the term ‘oligonucleotide’ has come to be synonymous with ...
openaire   +1 more source

Thin-layer chromatography of oligodeoxyribonucleotides

Journal of Chromatography A, 1972
E F, Noweswiat, M S, Poonian
openaire   +2 more sources

Oligodeoxyribonucleotide Phosphotriesters

2003
M, Koziolkiewicz, A, Wilk
openaire   +2 more sources

Sequence Analysis of Oligodeoxyribonucleotides

1994
D M, Black, P T, Gilham
openaire   +2 more sources

A New Approach to the Synthesis of Oligodeoxyribonucleotides

Angewandte Chemie International Edition in English, 1973
H, Köster, W, Heidmann
openaire   +2 more sources

Rapid synthesis of oligodeoxyribonucleotides

Tetrahedron Letters, 1979
R. Crea, T. Hirose, K. Itakura
openaire   +1 more source