Results 1 to 10 of about 200,944 (145)
Membranes, 2021 Caveolins are critical for the formation of caveolae, which are small invaginations of the plasma membrane involved in a variety of biological processes.
Hae-Jun Park +8 more
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Antioxidants, 2021 Typical 2-Cys peroxiredoxins (2-Cys Prx) are ubiquitous Cys-based peroxidases, which are stable as decamers in the reduced state, and may dissociate into dimers upon disulfide bond formation.
Carlos A. Tairum +9 more
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Frontiers in Molecular Biosciences, 2023 Introduction: Open Reading Frame 8 (ORF8) is a 121 amino acid length SARS-CoV-2 specific accessory protein that plays crucial roles in viral infectivity, and pathogenesis.
Mohammad Assadizadeh +1 more
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Frontiers in Neuroscience, 2021 α-synuclein (αSyn) is the main protein component of Lewy bodies, intracellular inclusions found in the brain of Parkinson’s disease (PD) patients. Neurotoxic αSyn species are broadly modified post-translationally and, in patients with genetic forms of PD,
Ana Martinez Hernandez +16 more
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Frontiers in Molecular Biosciences, 2022 Small heat shock proteins (sHsp) are a ubiquitous group of ATP-independent chaperones found in all three domains of life. Although sHsps in bacteria and eukaryotes have been studied extensively, little information was available on their archaeal homologs
Mousam Roy +2 more
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Molecules, 2021 A diimine ligand having two [2.2]paracyclophanyl substituents at the N atoms (L1) was prepared from the reaction of amino[2.2]paracyclophane with acenaphtenequinone.
Daisuke Takeuchi +2 more
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Insights into Aldehyde Dehydrogenase Enzymes: A Structural Perspective
Frontiers in Molecular Biosciences, 2021 Aldehyde dehydrogenases engage in many cellular functions, however their dysfunction resulting in accumulation of their substrates can be cytotoxic. ALDHs are responsible for the NAD(P)-dependent oxidation of aldehydes to carboxylic acids, participating ...
Kim Shortall +3 more
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Design of Protegrin-1 Analogs with Improved Antibacterial Selectivity
Pharmaceutics, 2023 Protegrin-1 (PG-1) is a cationic β-hairpin pore-forming antimicrobial peptide having a membranolytic mechanism of action. It possesses in vitro a potent antimicrobial activity against a panel of clinically relevant MDR ESKAPE pathogens.
Ilia A. Bolosov +11 more
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Concentration- and pH-Dependent Oligomerization of the Thrombin-Derived C-Terminal Peptide TCP-25
Biomolecules, 2020 Peptide oligomerization dynamics affects peptide structure, activity, and pharmacodynamic properties. The thrombin C-terminal peptide, TCP-25 (GKYGFYTHVFRLKKWIQKVIDQFGE), is currently in preclinical development for improved wound healing and infection ...
Ganna Petruk +5 more
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Differential FSH Glycosylation Modulates FSHR Oligomerization and Subsequent cAMP Signaling
Frontiers in Endocrinology, 2021 Follicle-stimulating hormone (FSH) and its target G protein-coupled receptor (FSHR) are essential for reproduction. Recent studies have established that the hypo-glycosylated pituitary FSH glycoform (FSH21/18), is more bioactive in vitro and in vivo than
Uchechukwu T. Agwuegbo +5 more
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