Results 21 to 30 of about 201,093 (287)

Heterologous Expression of Immature Forms of Human Islet Amyloid Polypeptide in Yeast Triggers Intracellular Aggregation and Cytotoxicity

Frontiers in Microbiology, 2020
Diabetes is a major public health issue that has attained alarming levels worldwide. Pancreatic aggregates of human islet amyloid polypeptide (IAPP) represent a major histopathological hallmark of type 2 diabetes.
Ana F. Raimundo, Ana F. Raimundo, Ana F. Raimundo, Sofia Ferreira, Sofia Ferreira, Maria I. Farrim, Cláudia N. Santos, Cláudia N. Santos, Cláudia N. Santos, Regina Menezes, Regina Menezes, Regina Menezes   +11 more
doaj   +1 more source

GPCRs Revisited: New Insights Lead to Novel Drugs

Pharmaceuticals, 2011
GPCRs play a critical role in human physiology and are a prime target for drug discovery globally. Novel insights into the functions of GPCRs are providing unique approaches to modulate these proteins to generate unique drug candidates.
Terry Reisine, Richard M. Eglen
doaj   +1 more source

Lipid-free Antigen B subunits from echinococcus granulosus: oligomerization, ligand binding, and membrane interaction properties [PDF]

, 2015
Background: The hydatid disease parasite Echinococcus granulosus has a restricted lipid metabolism, and needs to harvest essential lipids from the host.
Córsico, Betina, Ferreira, Ana M., Franchini, Gisela R., Kennedy, Malcolm W., Pórfido, Jorge L., Silva-Álvarez, Valeria   +5 more
core   +5 more sources

Distinct Pathway of Human T-Cell Leukemia Virus Type 1 Gag Punctum Biogenesis Provides New Insights into Enveloped Virus Assembly

mBio, 2018
The assembly of virus particles is a crucial aspect of virus spread. For retroviruses, the Gag polyprotein is the key driver for virus particle assembly.
John P. Eichorst, Yan Chen, Joachim D. Mueller, Louis M. Mansky   +3 more
doaj   +1 more source

Methionine 129 variant of human prion protein oligomerizes more rapidly than the valine 129 variant - Implications for disease susceptibility to Creutzfeldt-Jakob disease [PDF]

, 2004
The human PrP gene (PRNP) has two common alleles that encode either methionine or valine at codon 129. This polymorphism modulates disease susceptibility and phenotype of human transmissible spongiform encyphalopathies, but the molecular mechanism by ...
Abdessamad Tahiri-Alaoui, Andrew C. Gill, Petra Disterer, William James, Prusiner, Weissmann, Will, Bruce, Hill, Prusiner, Prusiner, Collinge, Windl, Palmer, Brown, Baker, Cervenakova, Parchi, Hill, Collinge, Hauw, Goldfarb, Goldfarb, Dlouhy, Dermaut, Croes, Liemann, Riek, Alonso, Baskakov, Jackson, Baskakov, Gill, Lu, Lu, Landon, Safar, Bessen, Zahn, Riek, Nguyen, Tahiri-Alaoui, Santini, Wong, Wildegger, Matouschek, Vendruscolo, Kim, Fasman, Baskakov, Qin, Oesch, Conway, Sayer, Rhie, Schatzl, Mead   +56 more
core   +1 more source

Liquid droplet formation by HP1α suggests a role for phase separation in heterochromatin. [PDF]

, 2017
Gene silencing by heterochromatin is proposed to occur in part as a result of the ability of heterochromatin protein 1 (HP1) proteins to spread across large regions of the genome, compact the underlying chromatin and recruit diverse ligands.
Agard, David A, Burlingame, Alma L, Elnatan, Daniel, Johnston, Jonathan B, Keenen, Madeline M, Larson, Adam G, Narlikar, Geeta J, Redding, Sy, Trnka, Michael J   +8 more
core   +1 more source

Interactions and substrate selectivity within the SctRST complex of the type III secretion system of enteropathogenic Escherichia coli

Gut Microbes, 2022
Many bacterial pathogens employ a protein complex, termed the type III secretion system (T3SS), to inject bacterial effectors into host cells. These effectors manipulate various cellular processes to promote bacterial growth and survival.
Irit Tseytin, Shir Lezerovich, Nofar David, Neta Sal-Man   +3 more
doaj   +1 more source

Oligomerization and Spatial Distribution of Kvβ1.1 and Kvβ2.1 Regulatory Subunits

Frontiers in Physiology, 2022
Members of the regulatory Kvβ family modulate the kinetics and traffic of voltage-dependent K+ (Kv) channels. The crystal structure of Kv channels associated with Kvβ peptides suggests a α4/β4 composition. Although Kvβ2 and Kvβ1 form heteromers, evidence
Sara R. Roig, Sara R. Roig, Silvia Cassinelli, Andre Zeug, Evgeni Ponimaskin, Antonio Felipe   +5 more
doaj   +1 more source

GABA transporter function, oligomerization state, and anchoring: correlates with subcellularly resolved FRET [PDF]

, 2009
The mouse γ-aminobutyric acid (GABA) transporter mGAT1 was expressed in neuroblastoma 2a cells. 19 mGAT1 designs incorporating fluorescent proteins were functionally characterized by [^3H]GABA uptake in assays that responded to several experimental ...
Abramoff, Bal, Bal, Bartholomäus, Bauman, Bjerggaard, Blackman, Boudanova, Boyd, Brückner, Chen, Chiu, Chiu, Cole, Corry, Corry, Deken, Doherty, Drenan, Elangovan, Farhan, Farhan, Farhan, Farhan, Feige, Fraser J. Moss, Gauthier, Geiser, Gordon, Guastella, Harris, Hastrup, Henry A. Lester, Hess, Holton, Hu, Hung, Imoukhuede, Jares-Erijman, Jia Hu, Joanna L. Jankowsky, Just, Kanner, Kanner, Kerschensteiner, Khakh, Kilic, Kimberly Scott, Korkhov, Kuryatov, Lakowicz, Lakowicz, Lester, Lester, Li, Lin, Loder, Loo, Madsen, Mager, Manley, Mazei-Robison, McHugh, Melikian, Michael W. Quick, Miranda, Miranda, Morel, Munro, Nashmi, Nashmi, Ormö, P.I. Imoukhuede, Quick, Raicu, Raicu, Ramamoorthy, Reiterer, Reith, Riven, Rizzo, Roux, Rudnick, Rudnick, Sallette, Schmid, Scholze, Sekar, Sheng, Son, Soragna, Sorkina, Spudich, Tadross, Taunton, Tokunaga, Torres, Torres, Wallrabe, Wang, Whitworth, Xia, Yamashita, Zacharias, Zahniser, Zhang   +105 more
core   +3 more sources

Matrilin-2 Is Proteolytically Cleaved by ADAMTS-4 and ADAMTS-5

Molecules, 2014
Matrilin-2 is a widely distributed, oligomeric extracellular matrix protein that forms a filamentous network by binding to a variety of different extracellular matrix proteins.
Zhengke Wang, Junming Luo, Satori Iwamoto, Qian Chen   +3 more
doaj   +1 more source