Results 31 to 40 of about 201,093 (287)
Frontiers in Molecular Biosciences, 2021 The essential enzyme ribonucleotide reductase (RNR) is highly regulated both at the level of overall activity and substrate specificity. Studies of class I, aerobic RNRs have shown that overall activity is downregulated by the binding of dATP to a small ...
Mahmudul Hasan +4 more
doaj +1 more source
A structural basis for IκB kinase 2 activation via oligomerization-dependent trans auto-phosphorylation. [PDF]
, 2013 Activation of the IκB kinase (IKK) is central to NF-κB signaling. However, the precise activation mechanism by which catalytic IKK subunits gain the ability to induce NF-κB transcriptional activity is not well understood.
Fusco, Amanda J +11 more
core +2 more sources
Nature Chemistry, 2016 Cyclic oligomers comprising strongly interacting redox-active monomer units represent an unknown, yet highly desirable class of nanoscale materials. Here we describe the synthesis and properties of the first family of molecules belonging to this compound category-differently sized rings comprising only 1,1'-disubstituted ferrocene units (cyclo[n], n ...
Michael S. Inkpen +6 more
openaire +5 more sources
Bacillus subtilis HelD, an RNA Polymerase Interacting Helicase, Forms Amyloid-Like Fibrils
Frontiers in Microbiology, 2018 HelD, an RNA polymerase binding protein from Bacillus subtilis, stimulates transcription and helps in timely adaptation of cells under diverse environmental conditions. At present, no structural information is available for HelD. In the current study, we
Gundeep Kaur +2 more
doaj +1 more source
Aβ42 fibril formation from predominantly oligomeric samples suggests a link between oligomer heterogeneity and fibril polymorphism [PDF]
Royal Society Open Science, 2019 Amyloid-β (Aβ) oligomers play a central role in the pathogenesis of Alzheimer's disease. Oligomers of different sizes, morphology and structures have been reported in both in vivo and in vitro studies, but there is a general lack of understanding about ...
Christine Xue +5 more
doaj +1 more source
Crystallization of Adenylylsulfate Reductase from Desulfovibrio gigas: A Strategy Based on Controlled Protein Oligomerization [PDF]
, 2011 Adenylylsulfate reductase (adenosine 5′-phosphosulfate reductase, APS reductase or APSR, E.C.1.8.99.2) catalyzes the conversion of APS to sulfite in dissimilatory sulfate reduction. APSR was isolated and purified directly from massive anaerobically grown
Chan, Sunney I. +9 more
core +1 more source
Biomolecules, 2019 Several recent investigations have demonstrated that members of the KCTD (Potassium Channel Tetramerization Domain) protein family are involved in fundamental processes.
Nicole Balasco +2 more
doaj +1 more source
Bi- and tri-dentate imino-based iron and cobalt pre-catalysts for ethylene oligo-/polymerization [PDF]
, 2013 Recent progress on the use of iron and cobalt complex pre-catalysts for ethylene reactivity is reviewed. The review is organized in terms of the denticity of the chelate ligands employed, with particular reference to the influence of the ligand ...
Feng, Chun +6 more
core +2 more sources
Mass Spectrometric Characterization of Oligomers in Pseudomonas aeruginosa Azurin Solutions [PDF]
, 2011 We have employed laser-induced liquid bead ion desorption mass spectroscopy (LILBID MS) to study the solution behavior of Pseudomonas aeruginosa azurin as well as two mutants and corresponding Re-labeled derivatives containing a Re(CO)_(3)(4,7-dimethyl-1,
Brutschy, Bernd +6 more
core +2 more sources
Frontiers in Neuroscience, 2018 Adenosine is a nucleoside mainly formed by degradation of ATP, located intracellularly or extracellularly, and acts as a neuromodulator. It operates as a volume transmission signal through diffusion and flow in the extracellular space to modulate the ...
Dasiel O. Borroto-Escuela +7 more
doaj +1 more source