Results 61 to 70 of about 201,093 (287)

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

The active form of quinol-dependent nitric oxide reductase from Neisseria meningitidis is a dimer

IUCrJ, 2020
Neisseria meningitidis is carried by nearly a billion humans, causing developmental impairment and over 100 000 deaths a year. A quinol-dependent nitric oxide reductase (qNOR) plays a critical role in the survival of the bacterium in the human host.
M. Arif M. Jamali, Chai C. Gopalasingam, Rachel M. Johnson, Takehiko Tosha, Kazumasa Muramoto, Stephen P. Muench, Svetlana V. Antonyuk, Yoshitsugu Shiro, Samar S. Hasnain   +8 more
doaj   +1 more source

Reconstructing the TIR side of the Myddosome: a paradigm for TIR-TIR interactions? [PDF]

, 2015
Members of the Toll-like receptor and interleukin-1 (IL-1) receptor families all signal via Toll/IL-1R (TIR) domain-driven assemblies with adaptors such as MyD88.
Bovijn, Celia, Burg, Elianne, Pauwels, Ewald, Peelman, Frank, Ruyssinck, Elien, Tavernier, Jan, Van Acker, Tim, Vyncke, Laurens   +7 more
core   +2 more sources

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Sulfatide-Hsp70 Interaction Promotes Hsp70 Clustering and Stabilizes Binding to Unfolded Protein

Biomolecules, 2015
The 70-kDa heat shock protein (Hsp70), one of the major stress-inducible molecular chaperones, is localized not only in the cytosol, but also in extracellular milieu in mammals. Hsp70 interacts with various cell surface glycolipids including sulfatide (3'
Yoichiro Harada, Chihiro Sato, Ken Kitajima   +2 more
doaj   +1 more source

A Quinolinone Compound Inhibiting the Oligomerization of Nucleoprotein of Influenza A Virus Prevents the Selection of Escape Mutants

Viruses, 2020
The emergence of resistance to currently available anti-influenza drugs has heightened the need for antivirals with novel mechanisms of action. The influenza A virus (IAV) nucleoprotein (NP) is highly conserved and essential for the formation of viral ...
Juliann Nzembi Makau, Ken Watanabe, Hiroki Otaki, Satoshi Mizuta, Takeshi Ishikawa, Yuji O. Kamatari, Noriyuki Nishida   +6 more
doaj   +1 more source

The AIM2 inflammasome is critical for innate immunity to Francisella tularensis. [PDF]

, 2010
Francisella tularensis, the causative agent of tularemia, infects host macrophages, which triggers production of the proinflammatory cytokines interleukin 1beta (IL-1beta) and IL-18. We elucidate here how host macrophages recognize F.
Alnemri, Emad S, Datta, Pinaki, Eisenlohr, Laurence, Fernandes-Alnemri, Teresa, Huang, Lan, Juliana, Christine, Kang, Seokwon, Landel, Carlisle P, McCormick, Margaret, McDermott, Erin, Solorzano, Leobaldo, Wu, Jianghong, Yu, Je-Wook   +12 more
core   +3 more sources

Flexibility and Dynamicity Enhances and Controls Supramolecular Self‐Assembly of Zinc(II) Metallogels

Advanced Functional Materials, EarlyView.
Zinc(II) coordination complexes with tunable aryloxy‐imine ligands exhibit controllable supramolecular self‐assembly into hierarchical fibrous structures. Coordination‐driven stacking, not π–π interactions, enables gelation, dynamic assembly/disassembly, and enhanced nanomechanical properties.
Merlin R. Stühler, Hesam Makki, Dorothee Silbernagl, Mathias Dimde, Kai Ludwig, Bengt E. Tegner, Christopher Greve, Konstantin Rausch, Eva M. Herzig, Anna Köhler, Alex J. Plajer   +10 more
wiley   +1 more source

Functional analysis and cryo-electron microscopy of Campylobacter jejuni serine protease HtrA

Gut Microbes, 2020
Campylobacter jejuni is a predominant zoonotic pathogen causing gastroenteritis and other diseases in humans. An important bacterial virulence factor is the secreted serine protease HtrA (HtrACj), which targets tight and adherens junctional proteins in ...
Urszula Zarzecka, Alessandro Grinzato, Eaazhisai Kandiah, Dominik Cysewski, Paola Berto, Joanna Skorko-Glonek, Giuseppe Zanotti, Steffen Backert   +7 more
doaj   +1 more source

Transient Expression of Tetrameric Recombinant Human Butyrylcholinesterase in Nicotiana benthamiana. [PDF]

, 2016
To optimize the expression, extraction and purification of plant-derived tetrameric recombinant human butyrylcholinesterase (prBChE), we describe the development and use of plant viral amplicon-based gene expression system; Tobacco Mosaic Virus (TMV) RNA-
Alkanaimsh, Salem, Arzola, Lucas, Dandekar, Abhaya M, Falk, Bryce W, Guerrero, Andrés, Hashimoto, Bryce, Hwang, Min Sook, Karuppanan, Kalimuthu, Lebrilla, Carlito B, McDonald, Karen A, Nandi, Somen, Phu, My L, Rodriguez, Raymond L, Tu, Aye M   +13 more
core   +1 more source