Results 161 to 170 of about 125,904 (241)

A distinct tau oligomer strain defines the molecular and proteomic landscape of rapidly progressive Alzheimer's disease. [PDF]

Acta Neuropathol
Saleem T, Möbius W, Schmitz M, da Silva Correia A, Thomas C, Canaslan S, Hermann P, Göbel S, Zafar S, Root E, Stadelmann C, Andreoletti O, Hoppert M, Fleming Outeiro T, Ferrer I, Younas N, Zerr I.   +16 more
europepmc   +1 more source

When Does Alzheimer's Disease Start? Plasma Aβ42/40 Assays Show Steep Changes at Aβ‐PET Centiloid 15, Mean Age of 66 Years

Annals of Neurology, EarlyView.
Objective Sporadic late‐onset Alzheimer's disease (AD) is characterized by a long pre‐clinical phase where amyloid‐beta (Aβ) and tau begin to accumulate in the brain. The primary objective was to determine the age at which AD starts by finding the average population age when both positron emission tomography (PET) Aβ (Aβ‐PET) and plasma Aβ42/40 become ...
Rodrigo Cánovas, Timothy Cox, Vincent Doré, Pierrick Bourgeat, Jurgen Fripp, Azadeh Feizpour, Rosita Shishegar, Christopher J. Fowler, Simon M. Laws, Tenielle Porter, Stephanie Rainey‐Smith, Leslie M. Shaw, Randall J. Bateman, Yan Li, Ovod Vitaliy, Michael W. Weiner, John C. Morris, Tammie L.S. Benzinger, Suzanne E. Schindler, Akinori Nakamura, Takeshi Iwatsubo, Takeshi Ikeuchi, Takashi Kato, Paul Maruff, Hamid R. Sohrabi, Christopher C. Rowe, Ralph N. Martins, Colin L. Masters, James D. Doecke, for the Alzheimer's Disease Neuroimaging Initiative   +29 more
wiley   +1 more source

The Role of Chemistry Across Disciplines From Humanities to Life Sciences in Understanding Complexity and Emergence

Angewandte Chemie, EarlyView.
This study explores the origins of life by linking prebiotic chemistry, the emergence of information‐carrying molecules such as RNA and proteins, and philosophical questions about consciousness. The study emphasizes the role of molecular evolution in the Central Dogma and provides insights into the chemical origins of biology and the basis of life's ...
Harald Schwalbe, Josef Wachtveitl, Alexander Heckel, Florian Buhr, Sabrina Toews, Thomas M. Schimmer   +5 more
wiley   +2 more sources

Novel Monoclonal Antibody Detects Small Aβ Oligomers More Sensitively Than Lecanemab in Alzheimer's Disease CSF, Serum and Culture Media

Annals of Neurology, EarlyView.
Objective Aqueously diffusible oligomers of the amyloid β‐protein (oAβ) are neurotoxic and play a role in neuronal dysfunction in Alzheimer's disease (AD). Accurate quantification of oAβ in brains and biofluids could be valuable for understanding and monitoring AD.
Yi Ran Xu, Youqi Tao, Alexandra M. Lish, Shaomin Li, Beth L. Ostaszewski, Amirah K. Anderson, Tracy Young‐Pearse, Trebor L. Lawton, Hyun‐Sik Yang, Dominic M. Walsh, Ting Yang, Dennis J. Selkoe   +11 more
wiley   +1 more source

Simultaneous Imaging of Cu+ and Cu2+ in Neural Cells Using DNAzyme Probes Reveals Mechanistic Link Between Copper Redox Imbalance and Amyloid Pathology

Angewandte Chemie, EarlyView.
We develop Cu+‐ and Cu2+‐specific DNAzyme fluorescent probes to visualize both copper redox states in living neurons. Aβ oligomers cause intracellular copper overload, triggering FDX1 dependent cuproptosis and generating ROS. This work links copper redox imbalance with Aβ pathology and offers a selective, sensitive way to monitor copper homeostasis in ...
Xiangli Shao, Zhenglin Yang, Zhihao Xu, Weijie Guo, Whitney Lewis, Boyi Gan, Yi Lu   +6 more
wiley   +2 more sources

TR-FRET between engineered nanobodies reveals the existence of endogenous CXCR4 oligomers. [PDF]

Commun Biol
Heuninck J, Bobkov V, Grison CM, Fumagalli A, Lescuyer M, Otun O, Bechara C, Lamarque L, Trinquet E, Bachelerie F, Marin P, Mouillac B, Granier S, van der Woning B, de Haard H, Smit MJ, Heukers R, Durroux T.   +17 more
europepmc   +1 more source

Nanomaterial‐Mediated Near‐Infrared Photothermal Neuromodulation for Neurologic Disorders

Advanced NanoBiomed Research, EarlyView.
This review summarizes how near‐infrared light activates photothermal nanomaterials to enable noninvasive neuromodulation with high spatiotemporal precision. It elucidates the underlying mechanisms, explores targeted therapeutic applications for neurological disorders, discusses integration with optogenetics and biosensors, and addresses future ...
Ting‐Ting Zeng, Yu‐Ge Wang, Ya‐Bing Zhang, Yuan‐Xin Bai, Si‐Tong Lin, Ting‐Ting Zhu, Yan‐Bo Zhou, Wei‐Tong Pan, Pan‐Miao Liu, Jian‐Jun Yang   +9 more
wiley   +1 more source

Tailoring Electronic Properties of Precision Graphene Nanoribbons via Nanopore Engineering

Angewandte Chemie, EarlyView.
Novel porous graphene nanoribbons incorporating [18]annulene nanopores, together with a nonporous GNR of identical width, have been synthesized. Spectroscopic and theoretical analyses reveal that nanopore incorporation effectively tunes their electronic properties by enlarging the bandgap, reducing charge‐carrier mobility, and modulating exciton ...
Kun Liu, Guanzhao Wen, Gianluca Serra, Nicolás Arisnabarreta, Hongde Yu, Andrea Lucotti, Yarden Peleg Walg, Hartmut Komber, Zhen‐Lin Qiu, Qing‐Song Deng, Ran He, Wenhui Niu, Thomas Heine, Eike Brunner, Mischa Bonn, Steven De Feyter, Matteo Tommasini, Hai I. Wang, Ji Ma, Xinliang Feng   +19 more
wiley   +2 more sources

Protection against Polymicrobial Sepsis by Chitin Oligomers is Fine-Tuned by <i>N</i>‑Acetyl‑d‑Glucosamine Residues. [PDF]

ACS Omega
Patel P, Agnihotri G, Siddappa S, Ravindran B, Saiyed T.   +4 more
europepmc   +1 more source

Domino Polymerization for the Synthesis of Reductively Degradable Poly(disulfide)s With Arbitrary Side‐Chain Structures

Angewandte Chemie, EarlyView.
We developed a novel domino polymerization to synthesize reductively degradable poly(disulfide)s with tunable side chains. A novel monomer bearing thiolactone and pyridyl disulfide groups reacts with various amines, enabling continuous ring‐opening and disulfide exchange.
Yukiya Kitayama, Ryodai Sakamoto, Atsushi Harada   +2 more
wiley   +2 more sources