Results 91 to 100 of about 20,124 (257)

Polymer−Oligonucleotide Conjugate Synthesis from an Amphiphilic Block Copolymer. Applications to DNA Detection on Microarray

, 2016
An amphiphilic block copolymer poly(tert-butylacrylamide-b-(N-acryloylmorpholine-N-acryloxysuccinimide)) (poly(TBAm-b-(NAM/NAS)) and a random copolymer poly(NAM/NAS), synthesized by the reversible addition−fragmentation chain transfer (RAFT ...
Agnès Perrin-Rubens (2689831), Marie-Thérèse Charreyrex (2689837), Christian Pichot (2666791), Alain Laurent (2689834), Arnaud Aigoui (2689825), Bertrand de Lambert (2689828), Carole Chaix (1428346)   +6 more
core   +1 more source

Synthesis and hybridization analysis of a small library of peptide-oligonucleotide conjugates

, 1998
A small library of 49 peptide–oligonucleotide conjugates were synthesized to explore the influence of various peptide side chains on the hybridization properties of the DNA.
Shankar Balasubramanian, Joseph G. Harrison   +1 more
core  

DNA sensors using a ferrocene-oligonucleotide conjugate

Using the redox-active DNA conjugate (ferrocene-modified oligonucleotide 12 mer) as a probe, the novel electrochemical gene sensor, which is sensitive, convenient, and not relying on radio isotope, has been developed.
イハラ, トシヒロ, Nakayama, Masamichi, Nakano, Koji, 中野, 幸二, 前田, 瑞夫, 井原, 敏博, ナカヤマ, マサミチ, Ihara, Toshihiro, ナカノ, コウジ, Maeda, Mizuo, マエダ, ミズオ   +10 more
core  

Peptide Synthesis on DNA

, 2013
(A) Structure of the [Leu]enkephalin–DNA conjugate. (B) High performance liquid chromatography chromatogram of the [Leu]enkephalin peptide synthesized using succinimidyl ester chemistry on a 20-base oligonucleotide modified with a 5′ primary ...
David R Halpin (3859), Pehr B Harbury (3860)   +1 more
core   +1 more source

Identification of a Peptide for Systemic Brain Delivery of a Morpholino Oligonucleotide in Mouse Models of Spinal Muscular Atrophy

, 2017
Splice-switching antisense oligonucleotides are emerging treatments for neuromuscular diseases, with several splice-switching oligonucleotides (SSOs) currently undergoing clinical trials such as for Duchenne muscular dystrophy (DMD) and spinal muscular ...
Shabanpoor, F, Gait, MJ, Hammond, Suzan M, Abendroth, F, Hazell, G, Hazell, Gareth, Wood, Matthew, Wood, MJA, Hammond, SM   +8 more
core   +1 more source

Impact of polyplex micelles installed with cyclic RGD peptide as ligand on gene delivery to vascular lesions

, 2010
Gene therapy is expected to open a new strategy for the treatment of refractory vascular diseases, so the development of appropriate gene vectors for vascular lesions is needed. To realize this requirement with a non-viral approach, cyclo(RGDfK) peptide (
Tetsuro Miyata, Makoto Oba, Yutaka Miura, Tsuyoshi Takato, Hiroyuki Koyama, Hideo Kagaya, Kazunori Kataoka, Takehiko Ishii   +7 more
core  

Peptide-PNIPAAm conjugate based hydrogels: Synthesis and characterisation

, 2011
Thermo-responsive PNIPAAm rich hydrogels with controllable properties have been prepared by introducing small quantities of peptide-PNIPAAm bioconjugates where the peptide self-assembled into a β-sheet rich fibrillar network.
Aline F. Miller, Saiani, Alberto; id_orcid, Nicola Tirelli, Maslovskis, Antons, Tirelli, Nicola, Antons Maslovskis, Saiani, Aline; id_orcid, Alberto Saiani   +7 more
core   +1 more source

Advancing design strategies in smart stimulus‐responsive liposomes for drug release and nanomedicine

BMEMat, EarlyView.
Schematic illustration of stimulus‐responsive liposomes designed for controlled drug release and nanomedicine. The innermost circle represents different liposomal structures, including unilamellar, multilamellar, and multivesicular liposomes. The middle layer illustrates the responsive phospholipid components.
Yuchen Guo, Nan Li, Daiwei Zhang, Jingya Gu, Zhihuan Liao, Zihao Teng, Xiangfu Du, Peter S. Timashev, Shipeng Chen, Shuaidong Huo   +9 more
wiley   +1 more source

Sequence-Specific Targeting of RNA with an Oligonucleotide−Neomycin Conjugate

, 2016
The synthesis of neomycin covalently attached at the C5-position of 2‘-deoxyuridine is reported. The synthesis outlined allows for incorporation of an aminoglycoside (neomycin) at any given site in an oligonucleotide (ODN) where a thymidine (or uridine ...
Irudayasamy Charles (2509774), Dev P. Arya (836583), Hongjuan Xi (2154616)   +2 more
core   +1 more source

Nanomaterial‐based immune therapeutic strategies in neurodegenerative diseases

BMEMat, EarlyView.
This review highlights the immunomodulatory potential of nanomaterials (NMs) in treating neurodegenerative diseases (NDs). It focuses on their roles in regulating innate and adaptive immune responses to maintain immune homeostasis. By providing insights into these mechanisms, the review lays the groundwork for innovative NMs therapeutic strategies to ...
Xinru Zhou, Jia Liu, Shulin Lai, Suhan Yin, Bingmin Luo, Longquan Shao, Yiyuan Kang   +6 more
wiley   +1 more source