Results 111 to 120 of about 651,747 (238)

High-Performance Thrombin Aptamers with a Peptide-Extended Recognition Interface. [PDF]

ACS Omega
Varizhuk IV, Kolganova NA, Gordeeva OB, Stomakhin AA, Talipova DA, Surzhikov SA, Timofeev EN.   +6 more
europepmc   +1 more source

Synthesis of Peptide-Oligonucleotide Conjugates via Condensation of a Lysine Side-Chain with a Thioester. [PDF]

J Org Chem
Muramoto S, Osawa T, Obika S.
europepmc   +1 more source

Peptide conjugation to enhance oligonucleotide delivery

, 2018
Thesis: Ph. D. in Biological Chemistry, Massachusetts Institute of Technology, Department of Chemistry, 2018.Cataloged from PDF version of thesis.Includes bibliographical references.The intracellular delivery of functional macromolecules remains an ...
Wolfe, Justin Mahoney
core  

Antibody-oligonucleotide conjugates: design principles, intracellular delivery, and translational opportunities. [PDF]

J Hematol Oncol
Li Y, Liu X, Zhang F, Fu R, Zhao D, Ye L, Zhu YZ.   +6 more
europepmc   +1 more source

Chemical Modification Strategies for Therapeutic Oligonucleotides: Mechanism Compatibility, Design Trade-Offs, and Translational Barriers. [PDF]

Molecules
Burton K, Dellinger K.
europepmc   +1 more source

Advancing Biochemical Molecule Registration, Representation and Search for New Drug Modalities. [PDF]

J Chem Inf Model
Pinto-Gil K, De Maria L, Noisier AFM, Leung S, Garon A, Frolov A, Chankeshwara SV, Bood M, Brive L, Tomkinson NP, Alvarez-Garcia D, Broddefalk J, Chooi KP, Ingar A, Bolt H, Ghiandoni GM.   +15 more
europepmc   +1 more source

Bioconjugates for improved delivery of oligonucleotide therapeutics to the central nervous system. [PDF]

Adv Drug Deliv Rev
Lee HJ, Xie Y, Greineder CF, Tessier PM.
europepmc   +1 more source

Purification of Advanced Therapeutics by Flow‐Through Pseudo‐Affinity Chromatography: Bi‐Specific mABs, Fc Fusion Proteins, and Adeno‐Associated Viruses

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Modern biopharmaceutical manufacturing requires purification platforms capable of processing structurally and functionally diverse products while addressing the challenge of removing persistent and high‐risk host cell proteins (HCPs).
Wenning Chu, Eduardo Barbieri, Arianna Minzoni, Shriarjun Shastry, Jacob P. LeBarre, Qingbo Shu, Taufika Williams, Xuanwen Li, Divya Chandra, Xuankuo Xu, Jerome Bill, David Roush, Joseph Taris, Patrick Gilbert, Andre Kiesewetter, Oliver Rammo, Michael Schulte, Christopher Major, Trina Mouchahoir, Steven Cramer, Cristiana Boi, Ruben G. Carbonell, Abraham Lenhoff, Stefano Menegatti   +23 more
wiley   +1 more source

Enhancing diabetes treatment by targeted nucleic acid and drug delivery using cell-penetrating peptides, peptide nucleic acids, and receptor targeting. [PDF]

Front Pharmacol
Zaric BL, Khodahemmati S, Zafirovic SS, Isenovic ER.   +3 more
europepmc   +1 more source

Vacancy defect‐induced electron homing breaks phosphodiester bonds for RNA depletion‐driven cancer therapy

BMEMat, EarlyView.
Illustration of 5% S‐vacancy Bi2S3 mediated phosphodiester bonds cleavage in RNA of hepatocellular carcinoma cells, which suppressing ERI3 expression, inhibiting cell proliferation and promoting apoptosis. Abstract Genome‐wide hypertranscription is a hallmark of malignant progression.
Chuncheng Yang, Zehao Shen, Guangming Xiang, Zhe Liu, Huaxin Liu, Jiabei Li, Ao Wang, Yelin Wu, Peiran Zhao, Xingwu Jiang, Jinghan Wang, Xiaoqing Jiang, Wenbo Bu   +12 more
wiley   +1 more source