Results 131 to 140 of about 651,747 (238)

Functionalizing Nucleic Acids: Synthesis and Purification Strategies for Bioconjugates as Biomaterials. [PDF]

Small
Alleva N, Zhang J, Ng DYW, Weil T, John T.   +4 more
europepmc   +1 more source

Hybrid Macrocyclic Peptides — Synthetic Strategies to Diversify and Cyclize Peptide Libraries in Phage Display Selections

Chemistry – A European Journal, EarlyView.
Hybrid macrocyclic peptides unite genetically encoded peptide libraries with the structural complexity of synthetic small molecules. This Review critically analyzes phage‐compatible cyclization and diversification chemistries, highlights emerging opportunities beyond traditional cysteine‐based approaches, and outlines how future advances may enable the
Titia Rixt Oppewal, Clemens Mayer
wiley   +1 more source

Weaknesses out of strength: PNA against the penicillin-binding proteins. [PDF]

Mol Ther Nucleic Acids
Wdowiak M.
europepmc   +1 more source

Raman Optical Activity as a Tool to Monitor Polynucleotide Conformation in Solutions

Chemistry – A European Journal, EarlyView.
Raman optical activity (ROA) studies of nucleic acids have been hindered by limited computational tools to link the spectra to the structure. The study shows that accurate density functional simulations are possible for model nucleotides, bringing more information about molecular geometry and dynamics in solutions.
Mohammed Siddhique Para Kkadan, Josef Kapitán, Jiří Kessler, Ondřej Zapletal, Valery Andrushchenko, Petr Bouř   +5 more
wiley   +1 more source

Targeting Oncogenic KRAS Using Peptide Nucleic Acid Oligomers Attached to Cell-Penetrating Peptides. [PDF]

Int J Mol Sci
Mondal J, Lam D, Alcindor TO, Gerritsen ME, Brotz TM, Kennedy J, Rehlaender B, Ross AJ, Levy DE, Bonagura CA, Lanzilotta WN, McCormick F, Rothman JH, Wolfe AL.   +13 more
europepmc   +1 more source

Formation of Lanthanide Luminescent Aggregates With RNA Using Tripodal Europium [Eu(III)] BTA Self‐Assembled Complexes

Chemistry – A European Journal, EarlyView.
The two Eu(III) complexes of 1.Eu and 2.Eu, that were formed in situ, were used to bind to yeast RNA and A10 (RNA) in a buffered pH 7 solution. The interaction gave rise to changes in the lanthanide‐centered emission because of direct binding of these complexes, which resulted in aggregation of the RNA, as demonstrated using phase‐contrast and atomic ...
Tómas A. Gudmundsson, Changzhuang Bai, Grace E. Maynard, Pall Thordarson, Thorfinnur Gunnlaugsson   +4 more
wiley   +1 more source

DNA-Lipid Nanodiscs with a Polyethylene Glycol Interface. [PDF]

J Am Chem Soc
Chandrasekhar S, Maffeo C, Karanth S, Bricker R, Kabuga J, Nunes Gonçalves DP, Aksimentiev A, Schmidt TL.   +7 more
europepmc   +1 more source

Oxidant‐Expedited Synthesis of H‐Phosphonates

European Journal of Organic Chemistry, EarlyView.
An exceptionally mild method for synthesis of alkyl and aryl H‐phosphonates from phosphites is reported, requiring only water and O2 (including air) as reagents. Mechanistic experiments indicate that the role of O2 (and other oxidants) in the transformation is to promote a radical mechanism, and that H2O functions to provide both the hydrogen and the ...
Dara T. Curran, Aidan C. Cregan, Niamh E. O’Dwyer, Jimmy Muldoon, Peter A. Byrne   +4 more
wiley   +1 more source

Immunoaffinity-Mimetic Assembly of Peptide-Aptamer Conjugates and Stem Cell-Derived Exosomes into Hierarchical Microgels for Spinal Cord Injury Repair. [PDF]

Adv Sci (Weinh)
Zheng D, Bai Y, Liu Z, Zhao Z, Kong Y, Xu Y, Jia Q, Zhu R, Hu Y.   +8 more
europepmc   +1 more source

Engineering mRNA‐LNP Medicines for the Ageing Brain: Opportunities and Challenges for Neurodegenerative Diseases

Exploration, EarlyView.
This review highlights recent advances in engineering messenger RNA (mRNA)‐lipid nanoparticles (LNPs) to cross the ageing blood–brain barrier and target neurodegenerative diseases. It outlines design principles, delivery routes, and translational challenges, charting a roadmap towards clinical application of mRNA‐LNP therapeutics for neurodegenerative ...
Abdel Ali Belaidi, Denzil L. Furtado, Francesca Alves, Rebecca M. Nisbet, Scott Ayton, Ashley I. Bush   +5 more
wiley   +1 more source