Results 1 to 10 of about 740,905 (276)
Light-generated oligonucleotide arrays for rapid DNA sequence analysis. [PDF]
Proceedings of the National Academy of Sciences, 1994 In many areas of molecular biology there is a need to rapidly extract and analyze genetic information; however, current technologies for DNA sequence analysis are slow and labor intensive. We report here how modern photolithographic techniques can be used to facilitate sequence analysis by generating miniaturized arrays of densely packed ...
Ann C. Pease +5 more
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Enhanced high density oligonucleotide array-based sequence analysis using modified nucleoside triphosphates [PDF]
Nucleic Acids Research, 1998 Pairs of high density oligonucleotide arrays (DNA chips) consisting of >96 000 oligonucleotides were designed to screen the entire 5.53 kb coding region of the hereditary breast and ovarian cancer BRCA1 gene for all possible sequence changes in the homozygous and heterozygous states.
J. Hacia
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Optimizing copy number variation analysis using genome-wide short sequence oligonucleotide arrays [PDF]
Nucleic Acids Research, 2010 The detection of copy number variants (CNV) by array-based platforms provides valuable insight into understanding human diversity. However, suboptimal study design and data processing negatively affect CNV assessment. We quantitatively evaluate their impact when short-sequence oligonucleotide arrays are applied (Affymetrix Genome-Wide Human SNP Array 6.
Derek A. Oldridge +4 more
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Rapid p53 sequence analysis in primary lung cancer using an oligonucleotide probe array [PDF]
Proceedings of the National Academy of Sciences, 1999 The p53 gene was sequenced in 100 primary human lung cancers by using direct dideoxynucleotide cycle sequencing and compared with sequence analysis by using the p53 GeneChip assay. Differences in sequence analysis between the two techniques were further evaluated to determine the accuracy and limitations of each method.
Steven A. Ahrendt +8 more
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Sequencing analysis of HPV-other type on an HPV DNA chip [PDF]
Obstetrics & Gynecology Science, 2018 ObjectivesTo identify the specific human papillomavirus (HPV) genotypes from HPV-other type on an HPV DNA chip test by sequencing.MethodsAmong 13,600 women undergoing a routine gynecology examination including Pap smear and/or HPV test by DNA chip test ...
Min-Jeong Kim, Jin Ju Kim, Sunmie Kim
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Systematic validation and atomic force microscopy of non-covalent short oligonucleotide barcode microarrays. [PDF]
PLoS ONE, 2008 BACKGROUND: Molecular barcode arrays provide a powerful means to analyze cellular phenotypes in parallel through detection of short (20-60 base) unique sequence tags, or "barcodes", associated with each strain or clone in a collection.
Michael A Cook +6 more
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Genomic Profiling of Liver Cancer [PDF]
Genomics & Informatics, 2013 Development of liver cancers is driven largely by genomic alterations that deregulate signaling pathways, influencing growth and survival of cancer cells. Because of the hundreds or thousands of genomic/epigenomic alterations that have accumulated in the
Ju-Seog Lee
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GSMA: Gene Set Matrix Analysis, An Automated Method for Rapid Hypothesis Testing of Gene Expression Data [PDF]
Bioinformatics and Biology Insights, 2007 Background Microarray technology has become highly valuable for identifying complex global changes in gene expression patterns. The assignment of functional information to these complex patterns remains a challenging task in effectively interpreting data and correlating results from across experiments, projects and laboratories. Methods which allow the
James P. Hamilton +13 more
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Comparison of Analytical and Clinical Performance of HPV 9G DNA Chip, PANArray HPV Genotyping Chip, and Hybrid-Capture II Assay in Cervicovaginal Swabs [PDF]
Journal of Pathology and Translational Medicine, 2016 Background: Human papillomavirus (HPV) infection can be detected by using several molecular methods, including Hybrid-Capture II (HC2) assay and variable HPV DNA chip tests, although each method has different sensitivities and specificities.
Ho Young Jung +5 more
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BMC Oral Health, 2023 Background Nonsyndromic cleft lip and/or without cleft palate (NSCL/P) with or without hypodontia is a common developmental aberration in humans and animals.
Norliana Ghazali +4 more
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