Results 201 to 210 of about 113,580 (306)

Natural variation of CsUGT71A60 determines growth and cold tolerance via regulating cytokinin glycosylation in Camellia sinensis

Plant Biotechnology Journal, EarlyView.
Summary Cold stress severely limits tea plant (Camellia sinensis) productivity, yet the molecular mechanisms underlying cold adaptation remain elusive. Here, we identified a cold‐inducible glycosyltransferase, CsUGT71A60, through integrative genome‐wide association studies (GWAS) and proteomic profiling.
Mingyue Zhao, Jingming Wang, Xinyuan Hao, Jieyang Jin, Junwei Tang, Yueyue Wang, Mengting Zhang, Tingting Jing, Wilfried Schwab, Ting Gao, Xinchao Wang, Chuankui Song   +11 more
wiley   +1 more source

Development of Antisense Tools to Study Bodo saltans and Its Intracellular Symbiont. [PDF]

Microbiologyopen
Ahrar M, Glenn L, Held M, Jackson A, Kus K, Hurst GDD, Chrostek E.   +6 more
europepmc   +1 more source

CsMYB213‐CsbHLH35 module regulates theanine biosynthesis in tea plants (Camellia sinensis L.)

Plant Biotechnology Journal, EarlyView.
Summary Theanine is a non‐protein free amino acid accumulated in tea plant leaves and makes a major contribution to the unique umami and sweet taste and a multitude of human health benefits of tea. However, its biosynthesis and transcriptional regulation in tea plant leaves remain to be fully understood.
Nianci Xie, Pinqian Zhou, Kuofei Wang, Feiyi Huang, Shuwei Yu, Haiping Fu, Saijun Li, Juan Li, Jian Zhao, Zhonghua Liu, Kunbo Wang   +10 more
wiley   +1 more source

A natural variation in the promoter of TaGDSL‐7D contributes to grain weight and yield in wheat

Plant Biotechnology Journal, EarlyView.
Summary Grain weight (GW) is a critical agronomic trait that greatly impacts wheat yield, yet the underlying genetic factors remain largely unknown. Here, we identify and characterize a candidate gene TaGDSL‐7D controlling GW in wheat through map‐based cloning, which encodes an ER‐located GDSL‐family protein.
Fei He, Dejie Du, Zhaoyan Chen, Liang Ma, Yunjie Liu, Zhaoju Li, Long Song, Zihao Jiang, Yujie Fan, Qixin Sun, Zhongfu Ni   +10 more
wiley   +1 more source

Exploring precision therapeutics: computational design of antisense oligonucleotides targeting AXL gene transcripts in multiple sclerosis treatment management. [PDF]

Front Chem
Shreevatsa B, Nagaraj A, Dharmashekar C, Jain A, Harendra B, Siddalingegowda SV, Al-Mazroua HA, Ahmad SF, Prasad SK, Srinivasa C, Shivamallu C, Kollur SP.   +11 more
europepmc   +1 more source

The Highly Conserved Cys95 Residue of Fructose‐1,6‐Bisphosphatase 1 Mediates the pH‐Driven Structure and Activity of the Enzyme and Photosynthesis

Plant, Cell &Environment, EarlyView.
ABSTRACT In Arabidopsis, exposure to microbial volatile compounds promotes thiol reduction of the Cys95 residue of the photosynthetic enzyme fructose‐1,6‐bisphosphatase (cFBP1). Although highly conserved in plants, the Cys95 function still remains unknown. We characterised recombinant wild‐type (WT) cFBP1 and a variant (C95S) in which the Cys95 residue
Samuel Gámez‐Arcas, Edurne Baroja‐Fernández, Francisco José Muñoz, Antonio J. Serrato, Mónica Balsera, Ángela María Sánchez‐López, Abdellatif Bahaji, Jesús Leal‐López, Rafael Jorge León Morcillo, Javier Pozueta‐Romero   +9 more
wiley   +1 more source

New Transferrin Receptor‐Targeting Conjugate Effectively Delivers DNA to Mouse Brain

Angewandte Chemie, Volume 137, Issue 24, June 10, 2025.
We present a novel RNA aptamer targeting the transferrin receptor (TfR), conjugated with DSPE lipid, which achieves remarkably efficient brain uptake, reaching brain‐to‐serum ratios as high as 6.5. Through fluorescence imaging and polymerase‐chain reaction analyses, we verify that this new conjugate successfully delivers a substantial amount of DNA ...
Min‐sun Song, Adrian H. Bustos, Lise Bastue, Justas Mikutavicius, Piotr Swiderski, Kelly J. Clemens, Nagy Habib, John Rossi, Kira Astakhova   +8 more
wiley   +2 more sources

Targeting FANCM using the antisense oligonucleotides to treat the ALT-positive cancers. [PDF]

Mol Ther Nucleic Acids
Naji S, Tong C, Ragupathi A, Xiao M, Zhang D.   +4 more
europepmc   +1 more source

SNA-modified antisense oligonucleotides: A new pathway for renal targeting? [PDF]

Mol Ther Nucleic Acids
Dumoulin B, Yamada K, Susztak K.
europepmc   +1 more source

Recent Cutting‐Edge Technologies for the Delivery of Peptide Nucleic Acid

Chemistry – A European Journal, Volume 31, Issue 34, June 17, 2025.
This review provides an overview of PNA cellular delivery methods, starting with traditional peptide‐based systems and progressing to advanced approaches using nanoparticles, liposomes, and calixarene. It highlights how these innovative strategies have opened the way for more effective and efficient PNA delivery, ultimately enhancing the potential for ...
Concetta Avitabile, Maria Teresa Cerasa, Antonia D'Aniello, Michele Saviano, Maria Moccia   +4 more
wiley   +1 more source