Results 241 to 250 of about 113,580 (306)

The Long Noncoding RNA LINC02820 Promotes Tumor Growth and Metastasis Through Regulating MYH9 Expression in Esophageal Squamous Cell Carcinoma

MedComm, Volume 6, Issue 6, June 2025.
This study demonstrates that the RNA‐binding protein IGF2BP2 binds to and stabilizes LINC02820, leading to elevated LINC02820 expression in esophageal squamous cell carcinoma (ESCC). Moreover, association of LINC02820 with MYH9 protein protects MYH9 from proteasomal degradation, thus upregulating MYH9 to promote tumor growth and metastasis in ESCC ...
Xiaomin Xu, Xinting Mao, Wenrong Liu, Yue Ming, Tingting Zhang, Yang Yang, A‐Lai Gu‐Ha, Yi‐Dan Lin, Yong Peng   +8 more
wiley   +1 more source

Metabolic Stability and Targeted Delivery of Oligonucleotides: Advancing RNA Therapeutics Beyond The Liver. [PDF]

J Med Chem
Anand P, Zhang Y, Patil S, Kaur K.
europepmc   +1 more source

Aptamers: Design, Theory, and Applications to Diagnosis and Therapy for Diseases. [PDF]

MedComm (2020)
Hassibian S, Amin M, Taghdisi SM, Sameiyan E, Ghaffari R, Alibolandi M, Ramezani M, Abnous K, Dehnavi SM.   +8 more
europepmc   +1 more source

Myeloid‐Derived Suppressor Cells in Cancer: Mechanistic Insights and Targeted Therapeutic Innovations

MedComm, Volume 6, Issue 6, June 2025.
This review summarizes the origin and biological characteristics of MDSCs, focusing on their immunological and nonimmunological roles in tumor progression. It also discusses the prognostic value of MDSCs and the latest advancements in clinical trials, highlighting the potential of emerging therapeutic strategies for cancer treatment and drug ...
Tianying Hu, Jianxue Zhai, Zhanda Yang, Jiajia Peng, Chuxuan Wang, Xinyao Liu, Yawen Li, Jiaqi Yao, Fengxi Chen, Haixia Li, Taixue An, Zongcai Liu, Haifang Wang   +12 more
wiley   +1 more source

Alternative splicing: hallmark and therapeutic opportunity in metabolic liver disease. [PDF]

Gastroenterol Rep (Oxf)
Jiang M, Alqahtani SA, Seto WK, Yilmaz Y, Pan Z, Valenti L, Eslam M.   +6 more
europepmc   +1 more source

Evaluation of an Antisense Oligonucleotide Targeting CAG Repeats: A Patient-Customized Therapy Study for Huntington's Disease. [PDF]

Life (Basel)
Ocampo-Ortega SA, Sierra-Sanchez VM, Blancas-Napoles CM, González-Carteño A, Mera-Jiménez E, Macías-Pérez ME, Hernandez-Guerra A, Romero-Nava R, Huang F, Hong E, Villafaña S.   +10 more
europepmc   +1 more source

Phase Separation: A New Dimension to Understanding Tumor Biology and Therapy

MedComm – Oncology, Volume 4, Issue 2, June 2025.
Liquid–liquid phase separation (LLPS) facilitates the assembly of biomolecular condensates by leveraging weak multivalent interactions. The low‐complexity domains, foldable domains of proteins, and nucleic acids provide multivalent interaction sites among different molecules and contribute to the formation of condensates.
Xingwen Wang, Minqiao Lu, Yi Zhang, Jiangwen Ma, Ying Hu   +4 more
wiley   +1 more source

Lipid Nanovesicles in Cancer Treatment: Improving Targeting and Stability of Antisense Oligonucleotides. [PDF]

Drug Des Devel Ther
Ding HY, Zhou H, Jiang Y, Chen SS, Wu XX, Li Y, Luo J, Zhang PF, Ding YN.   +8 more
europepmc   +1 more source

Mitochondrial Ribosomal Protein Family in Cancers: Mechanistic Insights and Therapeutic Implications

MedComm – Oncology, Volume 4, Issue 2, June 2025.
Mitochondrial ribosomal proteins (MRPs) are the important components of mitoribosome. They are aberrantly expressed in various human cancers. In this review, we introduce the roles of MRPs in tumorigenesis and development by regulating OXPHOS and other mechanisms.
Qian Chen, Yingli Zhang, Jin‐Jian Lu, Ting Li   +3 more
wiley   +1 more source